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Organocatalytic Synthesis of Benzimidazole Derivatives
Synthesis, 2022AbstractA synthetic route for the production of chiral derivatives of benzimidazole is presented. Different commercially available amines are evaluated as organocatalysts for the stereoselective aldol addition of N1-benzimidazolyl acetaldehyde, previously prepared by N-alkylation of benzimidazole, with cyclic ketones.
Elizabeth S. Lewkowicz +4 more
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New Benzimidazole Derivatives as Antimycobacterial Agents.
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Karel Waisser +3 more
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The structures of benzimidazole derivatives and their potential as tuberculostatics
Acta Crystallographica Section C Structural Chemistry, 2018Tuberculosis still remains a very important problem, especially its multidrug resistant varieties (MDR-TB). Among the potential tuberculostatics, there are two benzimidazole derivatives, namely 5,6-dimethyl-2-phenylethylbenzo[d]imidazole (1) and (E)-5,6-dimethyl-2-styryl-1H-benzo[d]imidazole (2) which showed significant tuberculostatic activities ...
Marek L. Główka +6 more
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New Derivatives of Benzimidazole and Their Antimicrobial Activity
Journal of Chemotherapy, 1999Azolium salts and neutral 2-aryl derivatives of benzimidazole, benzothiazole and benzoxazole were synthesized and compounds were identified by 1H and 13C NMR spectroscopy and microanalytical methods. In this work the salts 1 and the neutral compounds 2 were evaluated for their in vitro antimicrobial activity against standard strains: Enterococcus ...
Cetínkaya, E +4 more
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Antiaggregant Activity of a New Benzimidazole Derivative [PDF]
Bulletin of Experimental Biology and Medicine, 2014 Antiaggregant activity of a new tricyclic benzimidazole derivative, RU-891 compound, was studied on the model of ADP-induced platelet aggregation in vitro and intravascular platelet aggregation in vivo. We evaluated the effect of this substance on blood coagulation potential. Antiaggregant agent acetylsalicylic acid was used as the reference drug.
Alexander A. Spasov +3 more
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Benzimidazole Derivatives as Potential Anticancer Agents
Mini-Reviews in Medicinal Chemistry, 2013Benzimidazole ring system is found in many bioactive heterocyclic compounds because of their diverse biological and clinical applications. Furthermore, benzimidazole derivatives are structural isosters of naturally occurring nucleotides, thus they can interact with biological macromolecules such as proteins, enzymes and receptors. This review discusses
Ahmed A. El Rashedy +1 more
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ChemInform Abstract: Biologically Active Benzimidazole Derivatives
ChemInform, 2015AbstractReview: literature data on the synthesis and biological activities of benzimidazoles dring the past few years 2000‐2013; 82 refs.
R. Arulmozhi +3 more
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Photophysical processes of some benzimidazole derivatives
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005The photophysical properties of N-(alpha-naphthyl)-benzimidazole (alpha-NABI), N-(beta-naphthyl)-benzimidazole (beta-NABI) and N-(alpha-pyridyl)-benzimidazole (alpha-PYBI) were studied and alpha-NYBI exhibit intramolecular charge transfer fluorescence in polar solvents. The fluorescence of benzimidazoles can be quenched by acetic acid and the existence
Zhaobin Chen, Liheng Feng, Caihong Zhang
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Cytotoxic and antimicrobial potential of benzimidazole derivatives
Archiv der Pharmazie, 2021AbstractNew benzimidazole derivatives were synthesized and their structures were characterized by spectroscopic and microanalysis techniques. The cytotoxic properties of ten benzimidazole derivatives, five of which were synthesized in our previous studies, were determined against the lung cancer cell line, A549, and the healthy lung epithelial cell ...
Hasan Küçükbay +3 more
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Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin
Biochimica et Biophysica Acta (BBA) - General Subjects, 1978The binding and inhibitory properties of 11 benzimidazoles for bovine brain tubulin were investigated. The effects of the benzimidazoles on the initial rates of microtubule polymerization were determined by a turbidimetric assay. The median inhibitory concentrations (I50) for nocodazole, oxibendazole, parbendazole, mebendazole and fenbendazole ranged ...
Paul A. Friedman, Edward G. Platzer
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