Results 81 to 90 of about 636,119 (261)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring

, 2008
A series of benzimidazole derivatives bearing a heterocyclic ring imidazole (1), 5-chloroimidazole (2), 1,2,4-triazol (3), and imidazoline (4) were synthesized and evaluated for angiotensin II antagonistic activities.
Lu, XX, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Guo, XZ, Liu, XX, Shi, L, Lu, XX, Wang, R, Li, BG   +6 more
core  

Synthesis and characterization of some thiazolidinone derivatives possessing benzimidazole nucleus

, 2020
Synthesis of new thiazolidinone derivatives possessing benzimidazole nucleus by condensation reaction of various substituted mercapto acids in presence of anhydrous ZnCl 2.
Vaishali Goswami, Hitendra S Joshi, Prakash Mehta, Prakash Dawedra   +3 more
core  

Synthesis, Characterization and Biological Evaluation of 1, 2-Disubstituted Benzimidazole Derivatives using Mannich Bases

E-Journal of Chemistry, 2010
The ring system in which a benzene ring is fused to the 4,5-positions of imidazole is designated as benzimidazole. Condensations of 2-substituted benzimidazole derivatives were synthesized by different carboxylic acids using Mannich base and anti ...
B. Anil Reddy
doaj   +1 more source

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Unveiling the Potential of Metal and Non‐Metal Modified Porous Carbon for the Electrochemical Reduction of CO2

Carbon Energy, EarlyView.
Earth‐abundant metal‐ and non‐metal‐modified porous carbons offer a highly tunable platform for electrochemical CO2 reduction. This review shows how electronic interactions, active‐site coordination, pore architecture, and cooperative catalytic effects jointly govern intermediate stabilization, product selectivity, and device‐relevant CO2RR performance.
Hussein A. Younus, Asma Al Harthi, Mohammed Al Abri, Kamel Eid, Rashid Al Hajri   +4 more
wiley   +1 more source

SYNTHESIS OF SOME PYRIDO-BENZIMIDAZOLE AND PYRAZINO-BENZIMIDAZOLE DERIVATIVES AND THEIR ANTIFUNGAL ACTIVITY

, 1995
Some 2-aryl-4-hydroxypyrido[1,2-a]benzimidazole and 1-substituted 3-arylpyrazino-[1,2-a]benzimidazole derivatives were synthesized using 1-(2-arylethan-2-on)-2-acylbenzimidazole derivatives as starting materials.
GUVEN, K, DEMIRAYAK, S
core  

Polymer Molecular Interface Engineering—Enhanced Cu‐Based Catalysts for the CO2 Electroreduction Reaction

Carbon Energy, EarlyView.
This review highlights polymer‐mediated interfacial engineering strategies for Cu‐based electrocatalysts toward enhanced CO2RR, including steering the electronic structure of Cu, enhancing CO2 adsorption and activation, regulating the reaction microenvironment, constructing a molecular protective layer, and stabilizing the key intermediate.
Haoquan Peng, Xinyi Tan, Yalin Xie, Jianren Wang, Zhourong Xiao, Ailing Song, Desong Wang, Liming Dai   +7 more
wiley   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Benzimidazole Derivatives as Next‐Generation Anticonvulsant: Structural Requirements and Pharmacological Insight

The anticonvulsant activity of benzimidazole derivatives has been extensively studied, researchers exploring the structure‐activity relationship (SAR) to optimize their efficacy and safety profiles.
Arun Kumar, Manisha Srivastava, Kuldeep Singh, Sanjay Kumar, Syed Misbahul Hasan, Aleza Rizvi   +5 more
core   +1 more source