Results 101 to 110 of about 9,350 (208)

Vitamin B12‐Functionalized Nanogels for pH‐, and Redox‐Responsive Doxorubicin Delivery

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
A polymerizable 5′‐modified vitamin B12‐monomer enables the covalent incorporation of B12 into pH‐ and redox‐responsive nanogels for targeted doxorubicin delivery. The nanogels exhibit glutathione‐triggered drug release, potent antiproliferative activity against HT‐29 cancer cells, and strongly reduced cytotoxicity toward healthy cells.
Serife Dagdelen, Paula D. Mestizo, Marcin Mackiewicz, Agnieszka Kurdyn, Ewa Augustin, Marcin Karbarz, Felix Zelder   +6 more
wiley   +1 more source

Synthesis of Nitrogen‐Containing Heterocyclic Scaffolds and Applications in Scaffold Hopping: Development of an Aripiprazole Analog

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
A series of 12 novel fused [6,6] saturated and unsaturated nitrogen bicycles is synthesized in three to five steps and expands the CRAFT library's fragment space. A 2,6‐naphthyridin‐3‐ol core replaces the dihydroquinolinone scaffold of aripiprazole, a scaffold‐hopping strategy.
Temitayo Omowumi Alegbejo Price, Pieterjan Winant, Paulo Eliandro da Silva Júnior, Shaiani Maria Gil de Melo, Pedro Henrique Gobira, Julia Possamai Gimenes, Pedro Tenório Teixeira Fernandes Leite, Vinícius Gonçalves Maltarollo, Gustavo Henrique Goulart Trossini, A. Ganesan, Sâmia Regiane Lourenço Joca, Wim Dehaen, Flavio da Silva Emery   +12 more
wiley   +1 more source

Thermal and Kinetic Analysis of Benzimidazole Derivatives: Fenbendazole, Mebendazole, and Flubendazole. [PDF]

Molecules
Ledeți A, Pârvănescu RD, Ridichie A, Vlase T, Suciu O, Ghirlea O, Murariu M, Tomoroga C, Simu S, Ledeți I, Trandafirescu CM.   +10 more
europepmc   +1 more source

Antiplasmodial activity, structure-activity relationship and studies on the action of novel benzimidazole derivatives. [PDF]

Sci Rep, 2023
Escala N, Pineda LM, Ng MG, Coronado LM, Spadafora C, Del Olmo E.   +5 more
europepmc   +1 more source

Riluzole‐Derived Benzo[d]thiazoles as CK1δ Inhibitors for Amyotrophic Lateral Sclerosis‐Related Neurodegeneration

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Riluzole metabolism guided the design of benzo[d]thiazole inhibitors of casein kinase 1 delta (CK1δ), a kinase linked to amyotrophic lateral sclerosis (ALS). Docking supported ATP site recognition by the hydroxylamine metabolite and hydrazine analogues, leading to compounds showing improved potency and retained predicted blood brain barrier ...
Simone Adorinni, Ilenia Grieco, Stefano Morasso, Michelle Fornasier, Gianluca Novello, Veronica Salmaso, Loreto Martínez‐González, Eleonora Cescon, Davide Bassani, Giovanni Adriano Bassan, Teresa Gianferrara, Filippo Prencipe, Veronika Kost, Tatiana Da Ros, Paola Storici, Ana Martinez, Giampiero Spalluto, Stefano Moro, Stephanie Federico   +18 more
wiley   +1 more source

Benzimidazole derivatives as dual EGFR and BRAF^V600E inhibitors with pro-apoptotic antiproliferative potential. [PDF]

RSC Adv
Al-Wahaibi LH, Samir M, Bräse S, Youssif BGM, Morcoss MM.   +4 more
europepmc   +1 more source

Synthesis and Anti-Inflammatory Activity Evaluation of Some Benzimidazole Derivatives. [PDF]

Pharm Chem J, 2022
Moharana AK, Dash RN, Mahanandia NC, Subudhi BB.   +3 more
europepmc   +1 more source

Tailoring Liquid Crystalline Self‐Assembly in Dialkoxybenzimidazoles: The Role of Charge and Shape

ChemPhysChem, Volume 27, Issue 20, 28 October 2026.
Liquid crystalline self‐assembly in neutral and ionic dialkoxybenzimidazoles can be precisely tuned or suppressed by controlling molecular symmetry and charge, revealing key structure–property relationships for mesophase design. Liquid crystalline self‐assembly in neutral and ionic dialkoxybenzimidazoles can be precisely tuned or suppressed by ...
Eugen Wuckert, Nikolai Scheuring, Sara Simonovska, Nadia Kapernaum, Wolfgang Frey, Johanna Osterbrink, Andreas Taubert, Frank Gießelmann, Anna Zens, Sabine Laschat   +9 more
wiley   +1 more source

Synthesis, Characterization, and Bioactivity Investigation of Novel Benzimidazole Derivatives as Potential Antibacterial and Antifungal Agents. [PDF]

Molecules
Alghawi S, Sivakumar N, Hassan SHA, Abdel-Jalil RJ.   +3 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Benzimidazole Derivatives as Potential Lassa Virus Inhibitors. [PDF]

Molecules, 2023
Chen J, Xu L, Wang B, Zhang D, Zhao L, Bei Z, Song Y.   +6 more
europepmc   +1 more source