Results 111 to 120 of about 636,119 (261)

The photoswitchable ABAMIs for the future regulation of GWT1 in a spatiotemporal level

Smart Molecules, EarlyView.
The GWT1‐targeted azobenzene‐aminopyridine derivatives (ABAMIs), sensitive to the light at wavelengths from 365 to 520 nm, are separately developed as photochromic ligands to regulate bioactivity as well as the GWT1 functions. These molecules are smart tools in photopharmacological studies, giving an innovative method for understanding functional GWT1 ...
Qian Ding, Zongying Li, Zaiwei Xiao, Siting Zhang, Zimai Liu, Xiaoguang Shao, Zhong Li, Wen Fu, Xusheng Shao   +8 more
wiley   +1 more source

Synthesis and crystallographic characterization of some derivatives of benzimidazole

, 2003
Three derivatives of benzimidazole have been synthesized and characterized based on H-1 and C-13 NMR, FTIR, FAB-mass and UV spectra, and the structures of two compounds are characterized based on single crystal XRD studies.
Chebrolu P. Rao, Rissanen, Kari, Kari Rissanen, KALLE, N, Mohan Das, T., Das, T Mohan, RISSANEN, K, Rissaneh, Kari, Kalle, Nattinen, RAO, CP, T. Mohan Das, Rao, Chebrolu P, DAS, TM, Nattinen Kalle, Rao, Chebrolu P.   +14 more
core   +1 more source

Benzimidazole and Its Derivatives: Exploring Their Crucial Role in Medicine and Agriculture: A Short Review

Al-Kitab Journal for Pure Sciences
Benzimidazole and its structural analogues have garnered significant attention across diverse disciplines, including the fields of medicine and agriculture, owing to their remarkable versatility and immense potential.
Sarah Basil Fawzi Fawzi, Khalid Younis Zainulabdeen, Emad Abdul-Hussain Yousif, Husnun Amalia Enus Yunus, Nany Hairunisa Muhaini Umar   +4 more
doaj   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Photoactivation of Electron Donor–Acceptor Complexes Enables Deoxygenative Hydrogenation and Deuteration

Transformative Chemistry, EarlyView.
A photoinduced, NHC‐borane‐enabled radical deoxygenative hydrogenation featuring mild reaction conditions and excellent functional group tolerance has been developed. The reaction proceeds through a novel EDA complex photoactivation pathway. To explore the potential of NHC‐boranes in deuteration reactions, we developed a novel photoinduced protocol for
Mengqing Zhang, Changlei Zhu, Jingjing Wu   +2 more
wiley   +1 more source

Molecular docking and pharmacokinetics of benzimidazole-based FtsZ inhibitors for tuberculosis

Scientific Reports
Benzimidazole derivatives are privileged heterocyclic scaffolds with broad-spectrum pharmacological activities, notably antitubercular and antibacterial.
Pratiksha N. Sonwane, Manoj R. Kumbhare
doaj   +1 more source

Cytogenotoxic Effects of Fluopyram in Allium cepa Root Cells Involving Microtubule Disruption

Environmental Toxicology, EarlyView.
ABSTRACT Fluopyram is a next‐generation fungicide widely used in agriculture; however, its persistence in soils and mobility toward aquatic systems have raised concerns regarding potential ecotoxicological risks. This study evaluated the cytogenotoxic effects of a commercial fluopyram‐based pesticide formulation on Allium cepa root meristem cells ...
Carlos Filipe Camilo‐Cotrim, Natanael Alves da Silva, Gabriela Gomes Lima, Igor Rodrigues Vasconcelos, Luciana Souza Ondei, Elisa Flávia Luiz Cardoso Bailão, Antônio Sérgio Nakao de Aguiar, Marcelino Benvindo‐Souza, Leonardo Luiz Borges, Virgínia Damin, Luciane Madureira Almeida   +10 more
wiley   +1 more source

Benzimidazole Anthelmintic Compounds Albendazole and Fenbendazole Show Distinct Toxicity on the Nitrogen Fixing Bacterium Mesorhizobium loti and Its Symbiosis With Lotus japonicus

Environmental Toxicology, EarlyView.
ABSTRACT Veterinary medicines, which reach the soil mostly through the application of contaminated manures, can affect beneficial soil microorganisms, such as nitrogen‐fixing rhizobia bacteria, which engage in important symbiotic associations with plants.
Polyxeni Gorgia, Stathis Lagos, Christina N. Nikolaou, Nikoleta Basdeki, Christos Papadopoulos, Dimitrios G. Karpouzas, Daniela Tsikou   +6 more
wiley   +1 more source

Anthelmintic resistance in sheep nematodes in Australia: a compilation of recent test results

Australian Veterinary Journal, EarlyView.
Objective The results of recent faecal egg count reduction tests (FECRTs) were collated to provide an indication of the prevalence and severity of anthelmintic resistance in sheep nematodes across Australia and of changes in comparison to earlier testing reports.
RB Besier, NM Rolls
wiley   +1 more source