Results 11 to 20 of about 13,035 (231)

The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity

CHIMIA, 1973
A number of 2-substituted benzimidazoles has been prepared and the compounds were characterized by their physico-chemical and spectral properties. - Mutagenicity tests with two strains of Salmonella typhimurium revealed that on one hand the mutagenic ...
J.P. Seiler, H. Limacher
doaj   +2 more sources

Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation

Molecules, 2023
Herein, we present the design and synthesis of novel N-substituted benzimidazole-derived Schiff bases, and the evaluation of their antiviral, antibacterial, and antiproliferative activity.
Anja Beč, Maja Cindrić, Leentje Persoons, Mihailo Banjanac, Vedrana Radovanović, Dirk Daelemans, Marijana Hranjec   +6 more
doaj   +1 more source

α-Chymotrypsin-catalyzed synthesis of 2-substituted benzimidazole through retro-Claisen reaction

Green Chemistry Letters and Reviews, 2018
Benzimidazoles are important components of pharmaceutical compounds owing to their promising bioactivities. The green, safe, and efficient synthesis of benzimidazoles has always been one of the hot topics for chemical workers.
Lian-Sheng Liu, Zong-Bo Xie, Can Zhang, Lei-Han Fu, Hai-Bo Zhu, Zhang-Gao Le   +5 more
doaj   +1 more source

Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole [PDF]

Journal of the Serbian Chemical Society, 2014
Series of eight novel 5-substituted derivatives of benzimidazole were synthesized by condensation of corresponding diamine with ethyl-4-[4-(2-chlorophenyl)piperazin-1-yl] butanoate in refluxing 4N hydrochloric acid.
Vasić Vesna P., Penjišević Jelena Z., Novaković Irena T., Šukalović Vladimir V., Andrić Deana B., Kostić-Rajačić Slađana V.   +5 more
doaj   +1 more source

In-situ Fe electro-oxidation to Improve the Synthesis of Mono and Disubstituted Benzimidazoles

International Journal of Electrochemical Science, 2015
This paper presents an innovative green organic electrosynthesis to prepare benzimidazoles in methanol media at room temperature starting from o-phenylendiammines and benzaldehydes.
I. Monreal, L.J. Torres-Pacheco, M.T. Oropeza-Guzman, I.A. Rivero   +3 more
doaj   +1 more source

Design, Synthesis, Biological Evaluation, and Molecular Modeling of 2-Difluoromethylbenzimidazole Derivatives as Potential PI3Kα Inhibitors

Molecules, 2022
PI3Kα is one of the potential targets for novel anticancer drugs. In this study, a series of 2-difluoromethylbenzimidazole derivatives were studied based on the combination of molecular modeling techniques 3D-QSAR, molecular docking, and molecular ...
Xiangcong Wang, Moxuan Zhang, Ranran Zhu, Zhongshan Wu, Fanhong Wu, Zhonghua Wang, Yanyan Yu   +6 more
doaj   +1 more source

Activity of benzimidazoles against Dientamoeba fragilis (Trichomonadida, Monocercomonadidae) in vitro and correlation of beta-tubulin sequences as an indicator of resistance

Parasite, 2014
Recently, Dientamoeba fragilis has emerged as a significant and common enteropathogen. The majority of patients with dientamoebiasis present with gastrointestinal complaints and chronic symptoms are common. Numerous studies have successfully demonstrated
Stark Damien, Barratt Joel L.N., Roberts Tamalee, Marriott Deborah, Harkness John T., Ellis John   +5 more
doaj   +1 more source

Absence of Polymorphisms in Codons 167, 198 and 200 of All Seven β-Tubulin Isotypes of Benzimidazole Susceptible and Resistant Parascaris spp. Specimens from Australia

Pathogens, 2022
Benzimidazoles resistance is widespread in strongyle parasitic nematodes and associated with polym orphisms in the codons 167, 198 and 200 of isotype 1 β-tubulin (tbb-1).
Murat Özben, Georg von Samson-Himmelstjerna, Malene K. B. Freiin von Streit, Edwina J. A. Wilkes, Kristopher J. Hughes, Jürgen Krücken   +5 more
doaj   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Dual Photochemistry of Benzimidazole

The Journal of Organic Chemistry, 2023
Monomers of benzimidazole trapped in an argon matrix at 15 K were characterized by vibrational spectroscopy and identified as 1H-tautomers exclusively. The photochemistry of matrix-isolated 1H-benzimidazole was induced by excitations with a frequency-tunable narrowband UV light and followed spectroscopically.
José P. L. Roque, Mário T. S. Rosado, Rui Fausto, Igor Reva   +3 more
openaire   +3 more sources