Results 11 to 20 of about 18,814 (259)

Activity of benzimidazoles against Dientamoeba fragilis (Trichomonadida, Monocercomonadidae) in vitro and correlation of beta-tubulin sequences as an indicator of resistance

open access: yesParasite, 2014
Recently, Dientamoeba fragilis has emerged as a significant and common enteropathogen. The majority of patients with dientamoebiasis present with gastrointestinal complaints and chronic symptoms are common. Numerous studies have successfully demonstrated
Stark Damien   +5 more
doaj   +2 more sources

Boric Acid Catalyzed Convenient Synthesis of Benzimidazoles in Aqueous Media

open access: yesJournal of Chemistry, 2013
Synthesis of benzimidazoles has been developed by the o-phenylenediamine with aldehydes using boric acid an efficient catalyst under mild reaction conditions in aqueous media. The product is applicable to aryl and heteroaryl aldehydes.
Mohammad Reza Poor Heravi, Marjan Ashori
doaj   +2 more sources

PHARMACOKINETIC PROPERTIES OF A NEW KAPPA-OPIOID ANALGESIC RU-1205 COMPOUND AT A SINGLE PERORAL ADMINISTRATION

open access: yesФармация и фармакология (Пятигорск), 2021
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between its ...
A. A. Spasov   +8 more
doaj   +1 more source

Repurposing benzimidazoles to fight Cryptococcus [PDF]

open access: yes, 2021
As doenças humanas causadas pelos patógenos fúngicos Cryptococcus neoformans e Cryptococcus gattii estão associadas a altas taxas de mortalidade e protocolos terapêuticos tóxicos ou de custo proibitivo.
Rodrigues, Marcio L.   +1 more
core   +1 more source

Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation

open access: yesMolecules, 2023
Herein, we present the design and synthesis of novel N-substituted benzimidazole-derived Schiff bases, and the evaluation of their antiviral, antibacterial, and antiproliferative activity.
Anja Beč   +6 more
doaj   +1 more source

α-Chymotrypsin-catalyzed synthesis of 2-substituted benzimidazole through retro-Claisen reaction

open access: yesGreen Chemistry Letters and Reviews, 2018
Benzimidazoles are important components of pharmaceutical compounds owing to their promising bioactivities. The green, safe, and efficient synthesis of benzimidazoles has always been one of the hot topics for chemical workers.
Lian-Sheng Liu   +5 more
doaj   +1 more source

Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole [PDF]

open access: yesJournal of the Serbian Chemical Society, 2014
Series of eight novel 5-substituted derivatives of benzimidazole were synthesized by condensation of corresponding diamine with ethyl-4-[4-(2-chlorophenyl)piperazin-1-yl] butanoate in refluxing 4N hydrochloric acid.
Vasić Vesna P.   +5 more
doaj   +1 more source

Chemistry of 2-substituted benzimidazoles. 1. 5-Amino-2-methyl(aryl, arylalkyl, pyridyl)benzimidazoles

open access: yes, 2020
A series of 2-substituted benzimidazoles was synthesized.
Obynochnii A.A.   +8 more
core   +1 more source

In-situ Fe electro-oxidation to Improve the Synthesis of Mono and Disubstituted Benzimidazoles

open access: yesInternational Journal of Electrochemical Science, 2015
This paper presents an innovative green organic electrosynthesis to prepare benzimidazoles in methanol media at room temperature starting from o-phenylendiammines and benzaldehydes.
I. Monreal   +3 more
doaj   +1 more source

Design, Synthesis, Biological Evaluation, and Molecular Modeling of 2-Difluoromethylbenzimidazole Derivatives as Potential PI3Kα Inhibitors

open access: yesMolecules, 2022
PI3Kα is one of the potential targets for novel anticancer drugs. In this study, a series of 2-difluoromethylbenzimidazole derivatives were studied based on the combination of molecular modeling techniques 3D-QSAR, molecular docking, and molecular ...
Xiangcong Wang   +6 more
doaj   +1 more source

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