Results 31 to 40 of about 26,682 (264)
Inhibiting CK2 among Promising Therapeutic Strategies for Gliomas and Several Other Neoplasms
Pharmaceutics, 2022 In gliomas, casein kinase 2 (CK2) plays a dominant role in cell survival and tumour invasiveness and is upregulated in many brain tumours. Among CK2 inhibitors, benzimidazole and isothiourea derivatives hold a dominant position.
Emanuela B. Pucko, Robert P. Ostrowski
doaj +1 more source
Dual Photochemistry of Benzimidazole
The Journal of Organic Chemistry, 2023 Monomers of benzimidazole trapped in an argon matrix at 15 K were characterized by vibrational spectroscopy and identified as 1H-tautomers exclusively. The photochemistry of matrix-isolated 1H-benzimidazole was induced by excitations with a frequency-tunable narrowband UV light and followed spectroscopically.
José P. L. Roque +3 more
openaire +3 more sources
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine, 2018 The study was conducted using faecal samples from 62 dogs. We tested the ovicidal and larvicidal effects of albendazole (ABZ), mebendazole (MBZ), fenbendazole (FBZ) and flubendazole (FLU) by Egg hatch assay (EHA) and larval development assay (LDA).
Laura CĂTANĂ +4 more
doaj +1 more source
13C-NMR Chemical Shifts in 1,3-Benzazoles as a Tautomeric Ratio Criterion
Molecules, 2022 Benzimidazole is an important heterocyclic fragment, present in many biologically active compounds with a great variety of therapeutic purposes. Most of the benzimidazole activities are explained through the existence of 1,3-tautomeric equilibrium.
Efrén V. García-Báez +3 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2019 Reactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkylbenzimidazoles with arenes in the Brønsted superacid TfOH resulted in the formation of the corresponding Friedel–Crafts reaction products, 2-diarylmethyl and 2-arylmethyl-substituted benzimidazoles ...
Dmitry S. Ryabukhin +6 more
doaj +1 more source
Pharmaceuticals, 2021 Repurposing of approved non-antitumor drugs represents a promising and affordable strategy that may help to increase the repertoire of effective anticancer drugs.
Rosalba Florio +8 more
doaj +1 more source
Genotoxic mixtures and dissimilar action: Concepts for prediction and assessment [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund. This article is distributed under the terms of the creative commons Attribution license which permits any use, distribution, and reproduction in any medium, provided ...
A Bouslimi +29 more
core +2 more sources
Boric Acid Catalyzed Convenient Synthesis of Benzimidazoles in Aqueous Media
Journal of Chemistry, 2013 Synthesis of benzimidazoles has been developed by the o-phenylenediamine with aldehydes using boric acid an efficient catalyst under mild reaction conditions in aqueous media. The product is applicable to aryl and heteroaryl aldehydes.
Mohammad Reza Poor Heravi, Marjan Ashori
doaj +1 more source
Pharmaceuticals, 2021 We used classical linear and microwave-assisted synthesis methods to prepare novel N-substituted, benzimidazole-derived acrylonitriles with antiproliferative activity against several cancer cells in vitro.
Anja Beč +6 more
doaj +1 more source