Results 21 to 30 of about 26,682 (264)

Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation

Molecules, 2023
Herein, we present the design and synthesis of novel N-substituted benzimidazole-derived Schiff bases, and the evaluation of their antiviral, antibacterial, and antiproliferative activity.
Anja Beč, Maja Cindrić, Leentje Persoons, Mihailo Banjanac, Vedrana Radovanović, Dirk Daelemans, Marijana Hranjec   +6 more
doaj   +1 more source

Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole [PDF]

Journal of the Serbian Chemical Society, 2014
Series of eight novel 5-substituted derivatives of benzimidazole were synthesized by condensation of corresponding diamine with ethyl-4-[4-(2-chlorophenyl)piperazin-1-yl] butanoate in refluxing 4N hydrochloric acid.
Vasić Vesna P., Penjišević Jelena Z., Novaković Irena T., Šukalović Vladimir V., Andrić Deana B., Kostić-Rajačić Slađana V.   +5 more
doaj   +1 more source

In-situ Fe electro-oxidation to Improve the Synthesis of Mono and Disubstituted Benzimidazoles

International Journal of Electrochemical Science, 2015
This paper presents an innovative green organic electrosynthesis to prepare benzimidazoles in methanol media at room temperature starting from o-phenylendiammines and benzaldehydes.
I. Monreal, L.J. Torres-Pacheco, M.T. Oropeza-Guzman, I.A. Rivero   +3 more
doaj   +1 more source

Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer. [PDF]

, 2017
Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown.
Barrett, John W, Black, Morgan, Boutros, Paul C, Datti, Alessandro, Fung, Kevin, Ghasemi, Farhad, Le, Carson Cao Son Huu, Leong, Hon Sing, Lowerison, Matthew R, MacNeil, Danielle, Mymryk, Joe S, Nichols, Anthony C, Palma, David A, Pinto, Nicole, Ruicci, Kara M, Vizeacoumar, Frederick, Winquist, Eric, Yoo, John   +17 more
core   +1 more source

Design, Synthesis, Biological Evaluation, and Molecular Modeling of 2-Difluoromethylbenzimidazole Derivatives as Potential PI3Kα Inhibitors

Molecules, 2022
PI3Kα is one of the potential targets for novel anticancer drugs. In this study, a series of 2-difluoromethylbenzimidazole derivatives were studied based on the combination of molecular modeling techniques 3D-QSAR, molecular docking, and molecular ...
Xiangcong Wang, Moxuan Zhang, Ranran Zhu, Zhongshan Wu, Fanhong Wu, Zhonghua Wang, Yanyan Yu   +6 more
doaj   +1 more source

Absence of Polymorphisms in Codons 167, 198 and 200 of All Seven β-Tubulin Isotypes of Benzimidazole Susceptible and Resistant Parascaris spp. Specimens from Australia

Pathogens, 2022
Benzimidazoles resistance is widespread in strongyle parasitic nematodes and associated with polym orphisms in the codons 167, 198 and 200 of isotype 1 β-tubulin (tbb-1).
Murat Özben, Georg von Samson-Himmelstjerna, Malene K. B. Freiin von Streit, Edwina J. A. Wilkes, Kristopher J. Hughes, Jürgen Krücken   +5 more
doaj   +1 more source

New highlights of the syntheses of pyrrolo[1,2-a]quinoxalin-4-ones

Beilstein Journal of Organic Chemistry, 2014
The one-pot three-component reactions of 1-substituted benzimidazoles with ethyl bromoacetate and electron-deficient alkynes, in 1,2-epoxybutane, gave a variety of pyrrolo[1,2-a]quinoxalin-4-ones and pyrrolo[1,2-a]benzimidazoles.
Emilian Georgescu, Alina Nicolescu, Florentina Georgescu, Florina Teodorescu, Daniela Marinescu, Ana-Maria Macsim, Calin Deleanu   +6 more
doaj   +1 more source

Quantifying fenbendazole and its metabolites in self-medicating wild red grouse Lagopus lagopus scoticus using an HPLC–MS–MS approach [PDF]

, 2011
On red grouse estates in the UK the nematode parasite Trichostrongylus tenuis is often controlled by application of grit medicated with the anthelmintic fenbendazole (FBZ).
Aileen Adam, Blanchflower, Danaher, De Ruyck, Draycott, European Commission, European Medicines Agency, Hudson, Lucy M.I. Webster, Lukas F. Keller, McKellar, Miller, Mougeot, Newborn, Paul C.D. Johnson, Schmidt, Smith, William Mullen   +17 more
core   +1 more source

Zirconyl (IV) Nitrate as Efficient and Reusable Solid Lewis Acid Catalyst for the Synthesis of Benzimidazole Derivatives

Journal of Chemistry, 2013
The present paper introduces a simple and efficient method for the synthesis of substituted benzimidazoles by heterocyclization of different o-phenylenediamines and substituted aromatic carboxylic acid/aldehyde in the presence of zirconyl nitrate as ...
Pratapsinha B. Gorepatil, Yogesh D. Mane, Vilas S. Ingle   +2 more
doaj   +1 more source

Corrosion protection of mild steel in hydrochloric acid solution through the synergistic of alkylbenzimidazoles and semicarbazide pair – Electroanalytical and computational studies

Egyptian Journal of Petroleum, 2017
Hydrogen bonded interaction and synergistic effect on the corrosion protection properties of alkyl benzimidazoles and semicarbazide pair on mild steel in hydrochloric acid at 303, 308 and 313 K have been studied by polarization, electrochemical impedance
K. Ramya, K.K. Anupama, K.M. Shainy, Abraham Joseph   +3 more
doaj   +1 more source