Results 211 to 220 of about 17,710 (239)
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ChemInform, 1988
2H-Benzimidazole-2-spirocyclohexanes (1) when heated undergo a 1,5-sigmatropic rearrangement to 2,3-disubstituted 1H-benzimidazoles. A decided effect on the direction of this Isomerisation was observed with substituents in the homodiene ring.
Hans Suschitzky +3 more
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2H-Benzimidazole-2-spirocyclohexanes (1) when heated undergo a 1,5-sigmatropic rearrangement to 2,3-disubstituted 1H-benzimidazoles. A decided effect on the direction of this Isomerisation was observed with substituents in the homodiene ring.
Hans Suschitzky +3 more
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Mode of action of benzimidazoles
Parasitology Today, 1990Benzimidazoles represent the only class of truly broad-spectrum anthelmintics, however, they also show activity against fungi and mammalian cells. This raises the question as to why benzimidazoles can selectively kill helminths and yet exhibit little or no mammalian toxicity.
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Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin
Biochimica et Biophysica Acta (BBA) - General Subjects, 1978The binding and inhibitory properties of 11 benzimidazoles for bovine brain tubulin were investigated. The effects of the benzimidazoles on the initial rates of microtubule polymerization were determined by a turbidimetric assay. The median inhibitory concentrations (I50) for nocodazole, oxibendazole, parbendazole, mebendazole and fenbendazole ranged ...
Paul A. Friedman, Edward G. Platzer
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J. Chem. Soc., Chem. Commun., 1986
[Fe2S2L2]2– complexes co-ordinated by the mixed-donor N–S, N–O, or N–N ligands L1–L4 are characterised by electronic and n.m.r. spectroscopy and shown to undergo one-electron reduction to the corresponding trianions with e.s.r. spectra exhibiting a range of g-tensor values which are compared with those for [2Fe–2S]+ proteins of the Rieske type.
Peter Beardwood, John F. Gibson
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[Fe2S2L2]2– complexes co-ordinated by the mixed-donor N–S, N–O, or N–N ligands L1–L4 are characterised by electronic and n.m.r. spectroscopy and shown to undergo one-electron reduction to the corresponding trianions with e.s.r. spectra exhibiting a range of g-tensor values which are compared with those for [2Fe–2S]+ proteins of the Rieske type.
Peter Beardwood, John F. Gibson
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Benzimidazoles in a wormy world
Parasitology Today, 1990The problem of helminth infection is vast by anyone’s reckoning and is of equal interest to the veterinary surgeon and the clinician. To say that helminths are ubiquitous is almost an understatement: as parasites of livestock and humans, they represent the single most important group of infections on the planet, although many separate species are ...
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ChemInform Abstract: PHOSPHORYLATED BENZIMIDAZOLES. VI. PHOSPHORYLATED IMIDAZOLES AND BENZIMIDAZOLES
Chemischer Informationsdienst, 1981Abstract2‐Formyl‐benzimidazol (I) reagiert mit Anilin (II) und Diethylphosphit (III) zu einem Gemisch der Verbindungen (IV) und (V).
P. M. Zavlin +3 more
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ChemInform Abstract: Microwave Spectrum of Benzimidazole.
ChemInform, 1992AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Velino B. +4 more
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Benzimidazole Derivatives as Kinase Inhibitors
Current Medicinal Chemistry, 2014Benzimidazole is a common kinase inhibitor scaffold and benzimidazole-based compounds interact with enzymes by multiple binding modes. In some cases, the benzimidazole acts as part of the hinge-binding motif, in others it has a scaffolding role without evidence for direct hinge binding. Several of these compounds are ATP-competitive inhibitors and show
GARUTI, LAURA +2 more
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Chemischer Informationsdienst, 1980
AbstractDie Homopolykondensation der Verbindung (I) liefert das Oligomere (II).
P. M. Zavlin +2 more
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AbstractDie Homopolykondensation der Verbindung (I) liefert das Oligomere (II).
P. M. Zavlin +2 more
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