Results 61 to 70 of about 214,407 (289)

Crystal structure and Hirshfeld surface analysis of (4Z)-1-butyl-4-(2-oxopropylidene)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2018
The asymmetric unit of the title compound, C16H20N2O2, consists of two independent molecules differing slightly in the conformations of the seven-membered rings and the butyl substituents, where the benzene rings are oriented at a dihedral angle of 34.56 
Karim Chkirate   +5 more
doaj   +1 more source

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

open access: yesFrontiers in Psychiatry, 2021
In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification
Guoying Wang   +8 more
doaj   +1 more source

Pregabalin: a range of misuse-related unanswered questions [PDF]

open access: yes, 2019
© 2019 The Authors.
Chiappini, Stephania, Schifano, Fabrizio
core   +2 more sources

(4E)-1-Decyl-4-(2-oxopropylidene)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

open access: yesIUCrData, 2016
The title compound, C22H32N2O2, forms bilayers with the n-decyl chains in extended conformation oriented towards the interior of the bilayer structure. Weak C—H...O interactions help to stabilize the exterior surfaces.
Jihad Sebhaoui   +4 more
doaj   +1 more source

Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil

open access: yesFrontiers in Psychiatry, 2022
IntroductionSince the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous subcutaneous ...
Rebecca Casari   +6 more
doaj   +1 more source

Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam [PDF]

open access: yes, 2018
Introduction: Allostatic Load (AL) index proposes indicators for the functioningof the main potentially stress-affected systems. Sex differences instress response and stress-related diseases susceptibility have been describedfor the general population ...
D`Alessio, Luciana   +3 more
core   +1 more source

Benzodiazepine use, misuse, and abuse: A review

open access: yesMental Health Clinician, 2016
Benzodiazepine (BZD) abuse has reached epidemic levels and results in poor outcomes, particularly when combined with concomitant central nervous system depressants. BZDs are abused most commonly in combination with opioids and alcohol.
Allison Schmitz
semanticscholar   +1 more source

A case of schizophrenia with relapsed catatonia successfully treated with blonanserin transdermal patch

open access: yesNeuropsychopharmacology Reports, 2023
Background Catatonia is a syndrome that may present with stupor, immobility, and postural retention, and appears in various primary disorders including schizophrenia, depressive disorders, and neurodevelopmental disorders.
Minako Hagikura, Toshiya Inada
doaj   +1 more source

Use of the R-group descriptor for alignment-free QSAR [PDF]

open access: yes, 2005
An R-group descriptor characterises the distribution of some atom-based property, such as elemental type or partial atomic charge, at increasing numbers of bonds distant from the point of substitution on a parent ring system. Application of Partial Least
Gedeck, P.   +4 more
core   +1 more source

Comparisons Between Successful Versus Unsuccessful Switches From Benzodiazepines or Zolpidem (Z-Drug) to Controlled-Release Melatonin in Patients With Major Depressive Disorder and Insomnia

open access: yesFrontiers in Psychiatry, 2020
ObjectivesChronic use of benzodiazepines and zolpidem (BDZ/Z-drugs) leads to dependency, cognitive impairment, and falls. Although controlled-release melatonin (Melatonin CR) may be an alternative, a switch in clinical settings has proven difficult.
Ji Hyun An   +11 more
doaj   +1 more source

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