Results 61 to 70 of about 138,894 (338)

Crystal structure and Hirshfeld surface analysis of 3,4-dihydro-2-(2,4-dioxo-6-methylpyran-3-ylidene)-4-(4-pyridin-4-yl)-1,5-benzodiazepine

Acta Crystallographica Section E: Crystallographic Communications, 2019
The title compound, C20H17N3O3 [systematic name: 2-(6-methyl-2,4-dioxopyran-3-ylidene)-4-(pyridin-4-yl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine], is built up from a benzodiazepine ring system linked to pyridyl and pendant dihydropyran rings, where the ...
Lhoussaine El Ghayati, Youssef Ramli, Tuncer Hökelek, Mohamed Labd Taha, Joel T. Mague, El Mokhtar Essassi   +5 more
doaj   +1 more source

Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication

Case Reports in Nephrology and Dialysis, 2022
Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient.
Michaël Mekeirele, Silke Verheyen, Ruth Van Lancker, Stephanie Wuyts, Tim Balthazar   +4 more
doaj   +1 more source

Reducing Benzodiazepine Use for the Treatment of Insomnia and Supporting Nonpharmacological Therapies [PDF]

, 2019
Most medical organizations recommend against the use of benzodiazepine use for the treatment of insomnia, especially in the elderly. However, the percentage of the adult population on benzos increase with age: 7.5% in adults ages 51-64; 9% in adults over
Pyon, UnChan
core   +1 more source

Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam [PDF]

, 2018
Introduction: Allostatic Load (AL) index proposes indicators for the functioningof the main potentially stress-affected systems. Sex differences instress response and stress-related diseases susceptibility have been describedfor the general population ...
D`Alessio, Luciana, Remedi, Carolina, Roldán, Emilio J. A., Soria, Carlos A.   +3 more
core   +1 more source

Synthesis of Novel Dihydropyridine‐Iminium Salts Containing a Selenazine Core

Asian Journal of Organic Chemistry, EarlyView.
An efficient method to develop novel dihydropyrido[3,2‐e][1,3]selenazines iminium salts. A comparative study of the key reagent selenourea towards thiourea and urea was carried out to assess the contribution of chalcogen to the pathway. DFT (density functional theory) calculations have predicted the optimized minimum energy structure for the hybrid ...
Reinier Lemos, Mauro De Nisco, Yoana Pérez‐Badell, Gabriella Pinto, Marco Morelli, Margarita Suárez, Silvana Pedatella   +6 more
wiley   +1 more source

Zolpidem Profoundly Augments Spared Tonic GABAAR Signaling in Dentate Granule Cells Ipsilateral to Controlled Cortical Impact Brain Injury in Mice

Frontiers in Systems Neuroscience, 2022
Type A GABA receptors (GABAARs) are pentameric combinations of protein subunits that give rise to tonic (ITonicGABA) and phasic (i.e., synaptic; ISynapticGABA) forms of inhibitory GABAAR signaling in the central nervous system.
Jeffery A. Boychuk, Jeffery A. Boychuk, Corwin R. Butler, Corwin R. Butler, Katalin Cs. Smith, Katalin Cs. Smith, Miklos B. Halmos, Bret N. Smith, Bret N. Smith, Bret N. Smith, Bret N. Smith   +10 more
doaj   +1 more source

Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. [PDF]

, 2017
ObjectiveTo evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE).MethodsRats were treated with BRV (10 mg/kg) 10 min after ...
Alldredge, Biton, Brophy, Chen, Coeytaux, DeLorenzo, FDA, Gezalian, Gillard, Glauser, Griffin, Klein, Klein, Klein, Klitgaard, Klitgaard, Matagne, Matagne, Mazarati, Mazarati, Mazarati, Naylor, Nicolas, Reagan-Shaw, Ryvlin, Sanchez, Silbergleit, Stockis, Suchomelova, Treiman, Trinka, Wasterlain, Wood   +32 more
core   +1 more source

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård, Lotte Rasmussen, Morten Olesen, Anne Mette Skov Sørensen, Zandra Nymand Ennis, Joseph Kane, Sarah Baxter, Blánaid Hicks   +7 more
wiley   +1 more source

Assessing the clinical utility of the severity dependence scale for benzodiazepine use disorder

South African Journal of Psychiatry, 2021
Background: Benzodiazepines are often used as a part of mental health pharmacological management; however, often when prescribed for extended periods, they increase the risk of benzodiazepine use disorder (BUD).
Karishma Lowton, Gaveeta Chiba
doaj   +1 more source

Implementing physician‐led medication reviews for patients with diabetes and severe mental disorder: A randomized controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Patients with severe mental disorder and diabetes may be exposed to inappropriate polypharmacy increasing the risk of side effects and drug interactions. Although medication reviews may facilitate short‐term deprescribing, they are not known to affect clinical outcomes.
Johan Frederik Mebus Meyer Christensen, Signe Wegmann Düring, Gesche Jürgens   +2 more
wiley   +1 more source