Results 61 to 70 of about 156,110 (291)

Drug poisonings following bariatric surgery: Case series report

British Journal of Clinical Pharmacology, EarlyView.
Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari, Fannie LaJeunesse‐Trempe, Stephen Morley, Caroline Copeland   +3 more
wiley   +1 more source

Pharmacologic management of adolescent catatonia: A dual-case series [PDF]

Mental Health Clinician
Introduction Catatonia is a syndrome characterized by psychomotor and behavioral disturbances and is associated with a substantially increased mortality risk in adolescent patients.
Lauren Leiby, PharmD, BCPP, Lauryn Shiplett, PharmD, BCPP, Wendy Lin, PharmD, Matthew Dick, PharmD, BCPP, Hannah Thornton, PharmD, MS   +4 more
doaj   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

The relationship between self-reported substance use and psychiatric symptoms in low-threshold methadone maintenance treatment clients

Harm Reduction Journal, 2011
Background Ongoing psychiatric symptoms and substance use are common difficulties experienced by clients enrolled in methadone maintenance treatment (MMT).
Barrett Sean P, Fulton Heather G, MacIsaac Cindy, Stewart Sherry H   +3 more
doaj   +1 more source

Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABA_A Receptors

Brain Sciences, 2020
Gamma-aminobutyric acid, type A (GABAA) receptors are complex heterogeneous pentamers with various drug binding sites. Several lines of evidence suggest that benzodiazepines modulate certain GABAA receptors in a flumazenil-insensitive manner, possibly ...
Jing-Jing Lian, Yan-Qing Cao, Yu-Lei Li, Gang Yu, Rui-Bin Su   +4 more
doaj   +1 more source

Comparison of Triple Combination Oral Sedation Regimens for Pediatric Dental Treatment [PDF]

, 2019
Purpose: Compare the efficacy of two benzodiazepines (diazepam or midazolam) in combination with meperidine and hydroxyzine for pediatric dental sedation.
Henderson, Brett H
core   +1 more source

The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines [PDF]

, 2018
The illicit market for new psychoactive substances is forever expanding. Benzodiazepines and their derivatives are one of a number of groups of these substances and thus far their number has grown year upon year.
Haegeman, Caroline, Haider, Shozeb, Manchester, Kieran R., Maskell, Peter D., Waters, Laura   +4 more
core   +5 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

The effect of lemborexant on insomnia in patients with psychiatric disorders: Detailed evaluation using the Athens Insomnia Scale

PCN Reports
Aim Chronic insomnia disorder is common and associated with reduced quality of life. Benzodiazepine hypnotics are commonly prescribed for insomnia, but have potential side effects such as concentration impairment, somnolence, and dependence. Lemborexant (
Tomonori Murayama, Yuji Ito, Kenji Narita, Tetsuro Ishida, Shiro Hinotsu, Masahiko Fujita   +5 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of (4Z)-1-butyl-4-(2-oxopropylidene)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

Acta Crystallographica Section E: Crystallographic Communications, 2018
The asymmetric unit of the title compound, C16H20N2O2, consists of two independent molecules differing slightly in the conformations of the seven-membered rings and the butyl substituents, where the benzene rings are oriented at a dihedral angle of 34.56 
Karim Chkirate, Nada Kheira Sebbar, Tuncer Hökelek, Damodaran Krishnan, Joel T. Mague, El Mokhtar Essassi   +5 more
doaj   +1 more source