Results 41 to 50 of about 153,478 (337)
Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea
Frontiers in Neuroscience, 2023 Glutamate and γ-aminobutyric acid (GABA) are the two main neurotransmitters in the human brain. The balance between their excitatory and inhibitory functions is crucial for maintaining the brain’s physiological functions.
Piotr Kaczmarski +4 more
doaj +1 more source
Advanced Science, EarlyView.Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang +7 more
wiley +1 more source
Prescription Trends in Complex Regional Pain Syndrome: A Retrospective Case–Control Study
Brain Sciences, 2023 Objective: The objective of this study was to evaluate discrepancies in prescription trends for analgesic medications in complex regional pain syndrome (CRPS) patients based on recommendations in the literature.
Suzanna Shermon +4 more
doaj +1 more source
Trends in long-term prescribing of dependence forming medicines [PDF]
, 2019 Using patient-level primary care data to estimate the extent to which antidepressant medicines are prescribed to people continuously for long periods of time.
McManus, S. +3 more
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Schizophrenia Genetics Modulates Clinical Depressive Features
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Schizophrenia (SCZ) genetic liability, quantified by polygenic scores (PGS), may influence clinical phenotypes in major depressive disorder (MDD). We investigated the effect of the SCZ‐PGS derived from the latest SCZ genome‐wide association study (GWAS) on MDD symptom severity, comorbidities, and treatment outcomes.
Alessandro Serretti +13 more
wiley +1 more source
An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines
Molecules, 2016 Pyrrolo[1,4]benzodiazepines are tricyclic compounds that are considered “privileged structures” since they possess a wide range of biological activities.
George Varvounis
doaj +1 more source
The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia [PDF]
Korean Journal of Anesthesiology, 2017 BackgroundBenzodiazepines have been used preoperatively as part of an anesthesia regimen to attenuate the anxiety of patients. In this study, we aimed to examine the effect of oral triazolam, a short-acting benzodiazepine, on anxiety, sedation, and ...
Taehee Pyeon +4 more
doaj +1 more source
Journal de la Faculté de Médecine d'Oran, 2022 Introduction-A high consumption of benzodiazepines (BZDs) has been noticed sometimes outside the rules of prescription recommendations, which makes their consumption a major public health problem.
Derouicha Matmour +2 more
doaj +1 more source
Reducing Benzodiazepine Use for the Treatment of Insomnia and Supporting Nonpharmacological Therapies [PDF]
, 2019 Most medical organizations recommend against the use of benzodiazepine use for the treatment of insomnia, especially in the elderly. However, the percentage of the adult population on benzos increase with age: 7.5% in adults ages 51-64; 9% in adults over
Pyon, UnChan
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British Journal of Clinical Pharmacology, EarlyView.Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside +5 more
wiley +1 more source