Results 71 to 80 of about 211,779 (381)

Synthetic epoxy-pregnan steroids: effects on anxiety behavior in rats [PDF]

, 2016
Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like ...
Coirini, Hector, Ghini, Alberto Antonio, Rey, Mariana   +2 more
core   +1 more source

Benzodiazepines and risk of all cause mortality in adults: cohort study

British medical journal, 2017
Objectives To evaluate the risk of all cause mortality associated with initiating compared with not initiating benzodiazepines in adults, and to address potential treatment barriers and confounding related to the use of a non-active comparator group ...
E. Patorno, R. Glynn, R. Levin, Moa P. Lee, K. Huybrechts   +4 more
semanticscholar   +1 more source

Psychoactive prescription drug use and misuse in patients on opioid agonist treatment

British Journal of Clinical Pharmacology, EarlyView.
Aims To identify the patterns and trends in prescription drug use and misuse in patients on opioid agonist treatment. Methods We used data from the OPPIDUM programme, which collects data from patients attending substance abuse treatment facilities. Data collected include use of psychoactive prescription drugs in the past week.
Thomas Soeiro, Clémence Lacroix, Élisabeth Jouve, Élisabeth Frauger, Maryse Lapeyre‐Mestre, Joëlle Micallef   +5 more
wiley   +1 more source

Impact of Benzodiazepines on Outcomes of Mechanically Ventilated Pediatric Intensive Care Patients: A Retrospective Cohort Study

Critical Care Explorations
IMPORTANCE:. Benzodiazepines are the most frequently used sedatives in PICUs, but they are increasingly associated with negative outcomes. Understanding their impact on patient outcomes is critical to provide better sedative management for patients ...
Amanda R. Kolmar, MD, Daniela Bravo, MD, Ricardo A. Fonseca, MD, Michael A. Kramer, MD, Jinli Wang, MA, Kristin P. Guilliams, MD, MSCI, Brian M. Fuller, MD, MSCI   +6 more
doaj   +1 more source

Evolution of benzodiazepine receptor agonist prescriptions in general practice: A registry-based study

Frontiers in Public Health, 2022
BackgroundContrary to most European guidelines, benzodiazepine receptor agonists (BZRA) are often used continuously at a low dosage, being the most common form of long-term use.
Kristien Coteur, Pavlos Mamouris, Bert Vaes, Marc Van Nuland, Catharina Matheï, Birgitte Schoenmakers   +5 more
doaj   +1 more source

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia [PDF]

, 2011
OBJECTIVE: Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral ...
Bodmer, Michael, Jick, Susan S., Krähenbühl, Stephan, Meier, Christian, Meier, Christoph R.   +4 more
core   +2 more sources

Advances in radiopharmaceuticals for cancer radiotheranostics: CCK2R targeting as a paradigm for translational innovation

Cancer Communications, EarlyView.
Abstract Radiopharmaceuticals are reshaping the landscape of cancer therapy, offering a unique theranostic advantage that is becoming increasingly central to precision medicine. By labeling the same molecular scaffold with different radionuclides, these agents enable seamless integration of diagnostic imaging and targeted therapy.
Jing Li, Xuejun Wen, Rebeka Rita Reszegi, Hemavarshini Kamalrhaj, Wolfgang J. Parak, Xiaoyuan Chen, Jingjing Zhang   +6 more
wiley   +1 more source

The pharmacist’s response to the needs of patients undergoing treatment with psychotropic medication [PDF]

, 1999
The usage of psychotropic (Table 1) medication is considerable world wide. In Malta, this can be attested to by the numerous studies that have been conducted by the University of Malta Department of Pharmacy (in conjuction with other institutions and ...
Sant Fournier, Mary Ann
core  

Exposure–Response Analysis for Aripiprazole Once‐Monthly in Patients Diagnosed With Bipolar I Disorder

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Aripiprazole once‐monthly (AOM) is approved for the maintenance monotherapy treatment of bipolar I disorder (BP‐I) in adults. A previously developed population pharmacokinetic model was validated by applying it to data from patients diagnosed with BP‐I.
Xiaofeng Wang, Luann Phillips, Matthew Harlin, Karimah S. Bell Lynum, Frank Larsen, Pedro Such, Jessica Madera‐McDonough, Murat Yildirim, Ric M. Procyshyn, Craig Chepke, Julie Passarell   +10 more
wiley   +1 more source

Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life [PDF]

, 2003
Background: Older adults are the main recipients of repeat prescriptions for benzodiazepine (BZD) hypnotics. BZDs can impair cognitive function and may not aid sleep when taken continuously for years.
Collins, R., Curran, H.V., Fletcher, S., Iliffe, S., Kee, S.C.Y., Woods, B.   +5 more
core   +1 more source