Results 61 to 70 of about 16,919 (197)

Metal-mediated intramolecular hydroamination and hydro(acy)alkoxylation reactions [PDF]

, 2012
This PhD thesis describes work undertaken to effect asymmetric catalysis in hydroamination and hydro(acy)alkoxylation reactions of allenes. The introductory Chapter provides an overview of recent advances in asymmetric heterofunctionalisation reactions ...
Arbour, Jannine Louise, Arbour, Jannine Louise   +1 more
core   +1 more source

5-Hydroxy-7-methoxy-4H-chromen-4-one

Acta Crystallographica Section E, 2008
The molecular conformation of the title compound, C10H8O4, isolated from Laretia acualis, is stabilized by a strong intramolecular hydrogen bond between the hydroxyl and carbonyl groups. The crystal packing shows π–π stacking interactions.
Iván Brito, Jorge Bórquez, Luis Alberto Loyola, Matías López-Rodríguez   +3 more
doaj   +1 more source

Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]

, 2009
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
A Malassine, AC Epstein, AM Carter, AM Zafari, Anne E Chambers, AP MacKay, BJ Hawkins, C Moser, C Peyssonnaux, CW Redman, D Berg, D Gerald, DS Hoffmann, DS Tannetta, EL Bell, EL Pagé, FX Yi, GL Semenza, H Pelicano, Harpal Randeva, I Thaler, J Golab, J Sugawara, JA Martin, K Kanasaki, L Duley, L Wood, M Geiszt, M Ushio-Fukai, M Wang, N Kanayama, NS Chandel, P Huang, PH Maxwell, R Dworakowski, R Pijnenborg, RD Martin, RK Bruick, RW Redline, S Banerjee, S Lamond, S Melov, S Muzaffar, S Nemoto, SL Adamson, Subhasis Banerjee, T Cramer, T Torbergsen, Y Liu, Y Pan, Y Wang, YA Suh   +51 more
core   +4 more sources

Investigation of molecular design, synthesis, and biological assessment of new benzopyran derivatives

Journal of Applied Pharmaceutical Research
Background: Tuberculosis (TB) remains a global health challenge, necessitating the discovery of novel anti-tubercular agents. The N-(8-hydrazinyl-3,4-dihydro-2H-1-benzopyran-6-yl)-N'-phenyl urea (HSM-II) scaffold has shown potential in developing ...
Mahesh Agasa Ramu, Somashekhar Metri, Trupti A Hunnura, Koushallya Patil, Hanamant B Sannakki   +4 more
doaj   +1 more source

Photolytic release of bioactive carboxylic acids from fused pyran conjugates [PDF]

, 2018
New ester cages bearing the coumarin (2H-benzopyran-2-one) skeleton with extended π-systems as phototriggers, for glycine and β-alanine, as models of carboxylic acid bifunctional molecules with biological relevance, were evaluated under photolysis ...
Conceição, Rafaela, Costa, Susana P. G., Gonçalves, M. Sameiro T., Hungerford, Graham   +3 more
core   +1 more source

Chemotherapeutic Potential of 2-[Piperidinoethoxyphenyl]-3-Phenyl-2H-Benzo(b)pyran in Estrogen Receptor- Negative Breast Cancer Cells: Action via Prevention of EGFR Activation and Combined Inhibition of PI-3-K/Akt/FOXO and MEK/Erk/AP-1 Pathways.

PLoS ONE, 2013
Inhibition of epidermal growth factor receptor (EGFR) signaling is considered to be a promising treatment strategy for estrogen receptor (ER)-negative breast tumors.
Ruchi Saxena, Vishal Chandra, Murli Manohar, Kanchan Hajela, Utsab Debnath, Yenamandra S Prabhakar, Karan Singh Saini, Rituraj Konwar, Sandeep Kumar, Kaling Megu, Bal Gangadhar Roy, Anila Dwivedi   +11 more
doaj   +1 more source

Synthesis and in Vitro Antioxidant Activity Evaluation of 3-Carboxycoumarin Derivatives and QSAR Study of Their DPPH• Radical Scavenging Activity

Molecules, 2012
The in vitro antioxidant activities of eight 3-carboxycoumarin derivatives were assayed by the quantitative 1,1-diphenyl-2-picrylhydrazil (DPPH•) radical scavenging activity method.
Maria Teresa Sumaya-Martínez, Zeferino Gómez-Sandoval, Daniel Jaramillo Cano, Manuel Villanueva-García, Francisco J. Martínez-Martínez, Rodrigo Said Razo-Hernández, Ana Lilia Peraza-Campos   +6 more
doaj   +1 more source

Isolasi Dan Identifikasi Senyawa Kumarin Dari Tanaman Artemisia Annua (L). [PDF]

, 2008
The invention of new entity from plant was the basic step for chemistry and another sciences development, such as: pharmacy, biology, and medical. Besides that, it is needed to fulfill people needs on food, medicine, cosmetics, etc.
Isnawati, A. (Ani), Kamilatunisah, K. (Kamilatunisah), Mudahar, H. (Harfia)   +2 more
core  

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
Alsam, S., Jayasekera, S., Khan, Naveed Ahmed, Kim, K.S., Sissons, J., Stins, M.   +5 more
core   +3 more sources

Characterization of the xiamenmycin biosynthesis gene cluster in Streptomyces xiamenensis 318.

PLoS ONE, 2014
Xiamenmycin (1) is a prenylated benzopyran derivative with anti-fibrotic activity. To investigate the genetic basis of xiamenmycin biosynthesis, we performed genome mining in the xiamenmycin-producing Streptomyces xiamenensis wild-type strain 318 to ...
Yong Yang, Ling Fu, Jinlong Zhang, Linghan Hu, Minjuan Xu, Jun Xu   +5 more
doaj   +1 more source