Results 121 to 130 of about 28,920 (238)

Epiafzelechin, a Flavanol, Regulates Lipid Homeostasis Through Modulation of HMGCR, PCSK9, and PPAR‐α: Mechanistic Insights and Therapeutic Implications

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Hyperlipidemia remains a leading modifiable risk factor for cardiovascular morbidity and mortality. Statins are considered the cornerstone of treatment; however, their adverse effects and limited efficacy in certain patient populations necessitate exploration of novel therapeutic avenues. Epiafzelechin (EZN), a flavanol with established antioxidant and
Saud O. Alshammari, Nazifa Shahzad, Muhammad Nasir Hayat Malik, Qamar A. Alshammari, Abdulkarim Alshammari, Bassam S. M. Al Kazman, Muhammad Atif, Gideon F. B. Solre, Vivek Pandey   +8 more
wiley   +1 more source

Studies on the Derivatives of Berberine and Allied Alkaloides. I

, 1952
Chiaki Tani, Kenichi Ishibashi, Kiyoko Nakasato   +2 more
openalex   +2 more sources

The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation [PDF]

, 2019
Ding-wen Cao, Manman Liu, Rui Duan, Yifu Tao, Junshan Zhou, Weirong Fang, Junrong Zhu, Li Niu, Jianguo Sun   +8 more
openalex   +1 more source

Determination and Pharmacokinetic of Peiminine in Beagle Dogs by UPLC‐MS/MS

International Journal of Analytical Chemistry, Volume 2026, Issue 1, 2026.
This study centered on creating and validating a UPLC–MS/MS assay that is both reliable and simple, making it suitable for measuring peiminine levels in the plasma of beagle dogs. The established method was then employed with the ultimate goal of elucidating the pharmacokinetic behavior of the compound.
Qian Cheng, Xinyu Peng, Xiaotong Li, Xueying Jia, Bewketu Mehari   +4 more
wiley   +1 more source

Licochalcone A as Novel Multitarget Inhibitors via AChE, BuChE, and Synapsin III for Therapeutic Intervention Against Alzheimer’s Disease: Computer‐Aided Drug Design

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Alzheimer’s disease (AD) is characterized by key pathological features, including cholinergic dysfunction, amyloid‐beta (Aβ) aggregation, and disrupted synaptic transmission, positioning proteins such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and Synapsin III as critical targets for therapeutic strategies.
Ali Alimari, Bagher Seyedalipour, Payam Baziyar, Ehsan Joz Jalalian, Sohini Basu Roy   +4 more
wiley   +1 more source

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Characterized by its capacity to induce organ failure, sepsis constitutes a life‐threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking direct interventions targeting the restoration of cellular or organelle function.
Xiangxin Liao, Yixun Wang, Zhaohui Zhang, Xingguang Qu, Gaosheng Zhou, Laurent L′homme   +5 more
wiley   +1 more source

Effects of a combination of puerarin, baicalin and berberine on the expression of proliferator-activated receptor-γ and insulin receptor in a rat model of nonalcoholic fatty liver disease

, 2015
Weihan Zhao, Lijuan Liu, Yunliang Wang, Tangyou Mao, Junxiang Li   +4 more
openalex   +2 more sources

Progress in Research on Alleviating the Symptoms Associated With Advanced Cancer Using Traditional Chinese Medicine

Pain Research and Management, Volume 2026, Issue 1, 2026.
Advanced cancer continues to pose a substantial global challenge, with complex symptom burdens and limited therapeutic options. Traditional Chinese Medicine (TCM), grounded in holistic theory and the principles of syndrome differentiation, employs interventions such as herbal medicine, acupuncture, moxibustion, and acupoint‐based therapies to address ...
Chunmeng Jiao, Ting Zhang, Yachen Yang, Ruofan Zhang, Wenbo Liu, Yanqing Wang, Lei Huang   +6 more
wiley   +1 more source

Integration of microRNA–mRNA profiles and pathway analysis of plant isoquinoline alkaloid berberine in SGC-7901 gastric cancers cells

, 2018
Yanhong Yang, Na Zhang, Kundong Li, Juan Chen, Lang Qiu, Jufeng Zhang   +5 more
openalex   +2 more sources

Inhibitory Effects of Coptidis rhizoma and Berberine on Cocaine‐Induced Sensitization [PDF]

, 2007
Bombi Lee, Chae Ha Yang, Dae‐Hyun Hahm, Eun Sang Choe, Hyejung Lee, Kwang-Ho Pyun, Insop Shim   +6 more
openalex   +1 more source