Results 131 to 140 of about 26,756 (250)

hERG1 channels and potential therapeutics for long QT syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider, Kelly A. Aromolaran, Michael C. Sanguinetti, Ademuyiwa S. Aromolaran   +3 more
wiley   +1 more source

Berberine Intervention Mitigates Myocardial Ischemia-Reperfusion Injury in a Rat Model: Mechanistic Insights via miR-184 Signaling [PDF]

Haichen Yang,1,* Gang Cao,2,* Xia Li,3 Zhikun Zhao,4 Yong Wang,5 Fei Xu6 1Department of Emergency, The Affiliated Huai’an Hospital of Xuzhou Medical University and Huai’an second People’s Hospital, Huai’an, People’s Republic of China; 2Department
Yang H, Li X, Cao G, Xu F, Wang Y, Zhao Z   +5 more
core   +1 more source

Colon‐Targeted Berberine Nanoparticles‐Embedded Yeast Microcapsules for Regulation of Gut Immunity of Sepsis

eFood, Volume 7, Issue 4, August 2026.
A schematic representation illustrating the preparation of BGNP@YM and its therapeutic effects on septic mice induced by lipopolysaccharide (LPS). (A) BBR is first encapsulated within GNPs to form BGNPs with anti‐inflammatory activity, which are subsequently coated with YM via chemical precipitation to obtain the BGNP@YM oral delivery system.
Qing‐Qing Dong, Si‐Hui Wang, Chen‐Yan Wang, Ke‐Da Yang, Xiao‐Ling Xu, Yi Shi, Wei Chen   +6 more
wiley   +1 more source

Berberine ameliorates high-fat diet-induced metabolic disorders through promoting gut Akkermansia and modulating bile acid metabolism

Chinese Medicine
Background Coptidis Rhizoma, the rhizome of Coptis chinensis Franch., has long been employed in the treatment of diabetes. Its active component, berberine, has been utilized in clinical practice; however, the underlying mechanisms of its protective ...
Wei-jian Hang, Rui Yin, Xi-wei Kang, Lu He, Xuan Cao, Juan Chen   +5 more
doaj   +1 more source

Protective effects of berberine-loaded chitosan/solid lipid nanoparticles in streptozotocin-induced gestational diabetes mellitus rats

Experimental Biology and Medicine
Berberine, known as an antioxidant agent, can improve glycemic indices in animal models of diabetes; however, it is clinically limited by poor bioavailability.
Yu Liu, Shaik Althaf Hussain, Hua Yue
doaj   +1 more source

Berberine induces heme oxygenase-1 up-regulation through phosphatidylinositol 3-kinase/AKT and NF-E2-related factor-2 signaling pathway in astrocytes [PDF]

, 2012
[[abstract]]Our previous report has shown that berberine effectively inhibits LPS- and IFN-γ-induced neuroinflammation in microglia cells. Recently, we also reported that HO-1 (Heme oxygenase-1) may be a therapeutic target to regulate neuroinflammation ...
蔡政芳;Tsai, Cheng-Fang
core  

Experimental Models of Autoimmune Hepatitis: Disease Fidelity and Translational Relevance

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Autoimmune hepatitis (AIH) remains difficult to study mechanistically in patients because disease initiation is rarely observed directly, the relevant autoantigens differ across subsets, and clinically meaningful outcomes such as chronic inflammation, fibrosis, relapse, and treatment response evolve over time.
Laura Elisa Buitrago‐Molina, Matthias Hardtke‐Wolenski   +1 more
wiley   +1 more source

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model [PDF]

, 2010
[[abstract]]Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model.
Ho, YT (Ho, Yung-Tsuan); Yang, JS (Yang, Jai-Sing); Lu, CC (Lu, Chi-Cheng); Chiang, JH (Chiang, Jo-Hua); Li, TC (Li, Tsai-Chung); Lin, JJ (Lin, Jen-Jyh); Lai, KC (Lai, Kuang-Chi); Liao, CL (Liao, Ching-Lung); Lin, JG (Lin, Jaung-Geng); Chung, JG (Chung, Jing-Gung)
core   +1 more source

Interface Wettability Transition‐Driven Drug Release and Dual‐Phase Functionalization in Implant Abutment

Advanced Science, Volume 13, Issue 39, 13 July 2026.
A temporally controlled drug release coating is developed for abutments using a superhydrophobic coating self‐assembled on mesoporous silica. This surface provides sequential functionality: initial contamination resistance through non‐wetting, followed by controlled drug release via wettability transition.
Zhongchao Wang, Liang Shi, MingXia Li, Xiao Han, Jinghan Wang, Guangping Wang, Dan Zou, Bingyang Lu, Liyuan Fan   +8 more
wiley   +1 more source

Quantitative 2D Nuclear Magnetic Resonance of Complex Mixtures: From General Analytical Homo/Heteronuclear Methods to Intrinsically Quantitative HSQC Approaches

Chemistry–Methods, Volume 6, Issue 7, July 2026.
Quantitative 2D nuclear magnetic resonance methods provide accurate individual analyte concentrations in complex mixtures. This review provides a unified description and comparison of such methods, together with an overview of applications and practical implementation tips. Quantitative 2D nuclear magnetic resonance (NMR) spectroscopy has emerged as an
Jérémy Marchand, Estelle Martineau, Jonathan Farjon, Patrick Giraudeau   +3 more
wiley   +1 more source