Results 121 to 130 of about 28,872 (258)

Berberine Intervention Mitigates Myocardial Ischemia-Reperfusion Injury in a Rat Model: Mechanistic Insights via miR-184 Signaling [PDF]

Haichen Yang,1,* Gang Cao,2,* Xia Li,3 Zhikun Zhao,4 Yong Wang,5 Fei Xu6 1Department of Emergency, The Affiliated Huai’an Hospital of Xuzhou Medical University and Huai’an second People’s Hospital, Huai’an, People’s Republic of China; 2Department
Yang H, Li X, Cao G, Xu F, Wang Y, Zhao Z   +5 more
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Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6--E7 oncoproteins by targeting p53 in cervical cancer cell HeLa: A mechanistic study including molecular docking

, 2014
Increased evidence of chemo-resistance, toxicity and carcinogenicity necessitates search for alternative approaches for determining next generation cancer therapeutics and targets.
Khuda-Bukhsh, A.R., Saha, S.
core   +1 more source

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source

Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents

, 2014
Xin Jin1,2,* Tian-Hua Yan,3,* Lan Yan,1 Qian Li,4 Rui-Lian Wang,1 Zhen-Lin Hu,1 Yuan-Ying Jiang,1 Qing-Yan Sun,1 Yong-Bing Cao1 1School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China; 2School of Pharmacy, FuJian
Yan L, Jin X, Yan TH, Wang RL, Cao YB, Hu ZL, Sun QY, Li Q, Jiang YY   +8 more
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Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Synthesis of Six Natural Products Enabled by Selective Hydroxylation of Orcinaldehyde‐Like Substrates With an Enzyme Library

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Achieving selective (sp3)C–H hydroxylation can streamline the synthesis of complex organic molecules. Biocatalysis presents an opportunity to realize this transformation, however, identifying useful enzymes that enable synthetic strategies can be a challenge due to limitations in enzyme substrate scope.
Gonzalo J. Villegas Rodríguez, Evan O. Romero, Jonathan C. Perkins, Diego N. Rojas, Maximilian S. Hrigora, Alison R. H. Narayan   +5 more
wiley   +2 more sources

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

, 2015
Meng Yan,1 Kaiping Zhang,1 Yanhui Shi,1 Lifang Feng,1 Lin Lv,1 Baoxin Li1,2 1Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang, People’s Republic of China ...
Yan M, Lv L, Li BX, Shi YH, Feng LF, Zhang KP   +5 more
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Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Berberine-Pretreated Bone Marrow Mesenchymal Stem Cells Accelerate Skin Wound Healing in Rats With Burn Injuries. [PDF]

Int Wound J
ABSTRACT Berberine (BBR) is a natural isoquinoline alkaloid with antibacterial, anti‐inflammatory and pro‐angiogenic properties. This study aimed to investigate the therapeutic efficacy and underlying mechanism of a conditioned medium (CM) derived from berberine‐preconditioned bone marrow‐derived mesenchymal stem cells (BMSCs‐BBR).
Tan J, Chen C.
europepmc   +2 more sources

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model [PDF]

, 2010
[[abstract]]Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model.
Ho, YT (Ho, Yung-Tsuan); Yang, JS (Yang, Jai-Sing); Lu, CC (Lu, Chi-Cheng); Chiang, JH (Chiang, Jo-Hua); Li, TC (Li, Tsai-Chung); Lin, JJ (Lin, Jen-Jyh); Lai, KC (Lai, Kuang-Chi); Liao, CL (Liao, Ching-Lung); Lin, JG (Lin, Jaung-Geng); Chung, JG (Chung, Jing-Gung)
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