Results 101 to 110 of about 39,868 (244)

Berberine and berberrubine promote the expression of CYP3A4 via enhancing the binding of nuclear receptor PXR

BMC Pharmacology and Toxicology
Background Berberine is currently co-administered with statins in clinical practice for hyperlipidemia management. This study aimed to investigate the effects of berberine and berberrubine on CYP3A4 expression and the regulatory mechanism.
Gui-mei Xiao, Ting Lu, Dandan Zhu, Ming-yi Liu   +3 more
doaj   +1 more source

Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells [PDF]

, 2016
published_or_final_versio
Feng, Y, LI, S, TAN, HY, Tsang, CM, Tsao, GSW, Wang, N, Wang, X   +6 more
core   +2 more sources

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Enhanced Antifungal Bioactivity of Coptis Rhizome Prepared by Ultrafining Technology [PDF]

, 2014
The aim of this study was to identify and quantify the bioactive constituents in the methanol extracts of Coptis Rhizome prepared by ultrafining technology.
Chen, Guo-Feng, Chen, Po-Hsun, Huang, Jenn-Wen, Kuo, Ping-Chung, Liao, Ming-Yuan, Lin, Yao-Tung, Wong, Lin-Fu, Yang, Mei-Lin   +7 more
core   +3 more sources

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song, Di Liu, Shi Chen, Yufeng Tan, Siyu Wang, Shihan Li, Yutong Qin, Guofeng Li, Xufang Tian, Lan Yang, Chong Yuan, Junbo Gou, Wei Huang, Shilin Chen, Yifei Liu   +14 more
wiley   +1 more source

Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells.

PLoS ONE, 2014
Berberine is a primary component of the most functional extracts of Coptidis rhizome used in traditional Chinese medicine for centuries. Recent reports indicate that Berberine has the potential to prevent and treat Alzheimer's disease (AD).
Xiaofeng Liu, Jie Zhou, Morad Dirhem Naji Abid, Huanhuan Yan, Hao Huang, Limin Wan, Zuohua Feng, Juan Chen   +7 more
doaj   +1 more source

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu, Lihua Zhu, Chenyu Shao, Siyi Xie, Na Li, Xinyu Li, Fang Wang, Lvwen Peng, Huiying Jin, Fanghuizi Shang, Jianan Huang, Zhonghua Liu, Na Tian, Shuoqian Liu   +13 more
wiley   +1 more source

A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats [PDF]

, 2012
published_or_final_versio
Cheung, F, Chow, OY, Feng, Y, Su, W, Tong, Y, Wang, MN, Wang, X   +6 more
core   +1 more source

Evaluation of HSYA and Carthamin Accumulation in Safflower (Carthamus tinctorius L.) Induced by Chemical Mutagens (EMS and SA) in M1 and M2 Generations

Plant Breeding, EarlyView.
ABSTRACT Historically cultivated for medicinal and dyeing purposes, safflower (Carthamus tinctorius L.) saw a shift towards widespread oilseed production after the 1920s due to the growing importance of oils. However, there is a renewed interest in its medicinal and dyeing properties today.
Tansu Uskutoglu, Nurullah Kartaloglu, Belgin Cosge Senkal   +2 more
wiley   +1 more source

Membrane of Candida albicans as a target of berberine

BMC Complementary and Alternative Medicine, 2017
Background We investigated the mechanisms of anti-Candida action of isoquinoline alkaloid berberine, active constituent of medically important plants of Barberry species.
Nataša Zorić, Ivan Kosalec, Siniša Tomić, Ivan Bobnjarić, Mario Jug, Toni Vlainić, Josipa Vlainić   +6 more
doaj   +1 more source