Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source
A study on the ameliorative effects of goldenseal, goat's rue extracts, and berberine on glucose uptake compared to metformin in a cellular model [PDF]
This study examines the effects of goat's rue (Galega officinalis L.), goldenseal (Hydrastis canadensis L.) leaves, root extracts, and berberine on glucose uptake in HepG2 cells.
White, Kenneth, Kandunuri, Kiran Kumar
core +1 more source
Review of phytochemical and antioxidant properties of Ethiopian medicinal plants
JSFA reports, EarlyView.Abstract Ethiopia possesses a rich ethnobotanical heritage and diverse medicinal flora that play an important role in traditional healthcare. Many Ethiopian medicinal plants contain bioactive phytochemicals with potential antioxidant properties. This capital of indigenous knowledge has contributed to the documentation of different medicinal plants that
Endalamaw Yihune +2 more
wiley +1 more source
Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents [PDF]
, 2014 Xin Jin1,2,* Tian-Hua Yan,3,* Lan Yan,1 Qian Li,4 Rui-Lian Wang,1 Zhen-Lin Hu,1 Yuan-Ying Jiang,1 Qing-Yan Sun,1 Yong-Bing Cao1 1School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China; 2School of Pharmacy, FuJian
Yan L +8 more
core
BMC Pharmacology and ToxicologyBackground Berberine is currently co-administered with statins in clinical practice for hyperlipidemia management. This study aimed to investigate the effects of berberine and berberrubine on CYP3A4 expression and the regulatory mechanism.
Gui-mei Xiao +3 more
doaj +1 more source
Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines [PDF]
Iranian Journal of Basic Medical Sciences, 2015 Objective(s):Berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor properties in some in vitro systems. But the effect of berberine on breast cancer has not yet been completely studied.
Elmira Barzegar +6 more
doaj
Frontiers in Physiology, 2011 Berberine is a plant alkaloid with multiple pharmacological actions, including antidiarrhoeal activity and has been shown to inhibit Cl- secretion in distal colon.
Rodrigo eAlzamora +6 more
doaj +1 more source
Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, EarlyView.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency [PDF]
, 2015 Meng Yan,1 Kaiping Zhang,1 Yanhui Shi,1 Lifang Feng,1 Lin Lv,1 Baoxin Li1,2 1Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang, People’s Republic of China ...
Yan M +5 more
core