Results 71 to 80 of about 26,756 (250)
Advanced Intelligent Discovery, EarlyView.This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng +4 more
wiley +1 more source
Berberine showed no cytotoxicity. [PDF]
, 2014 Cells were starved in serum-free DMEM supplemented with 0.25% BSA and treated with various doses of berberine or metformin for 24 h. LDH concentrations in medium and cells were detected.
Jun Yin (94374) +8 more
core +1 more source
Rhizoma coptidis and berberine-induced activation of murine microglia N9 cells [PDF]
, 2010 Aims of the study: To investigate the effect of water extract of Rhizoma coptidis (WEC) and berberine on the activation of murine microglia N9 cells and corresponding mechanism related to ...
Wang, Long-Xing +4 more
core +1 more source
Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies
Animal Research and One Health, EarlyView.Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu +6 more
wiley +1 more source
iScience, 2022 Summary: Colorectal cancer is one of the most serious tumors and berberine can inhibit the recurrence and transformation of colorectal adenoma into colorectal cancer.
Shi-Hai Yan +7 more
doaj +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity [PDF]
, 2018 Muhammad Umar Khayam Sahibzada,1,2 Abdul Sadiq,2 Hani S Faidah,3 Muhammad Khurram,4 Muhammad Usman Amin,4 Abdul Haseeb,5,6 Maria Kakar4 1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan; 2Department of ...
Sadiq A +6 more
core
Radiosensitization of esophageal cancer cells by berberine. [PDF]
, 2013 (A), Radiosensitization by berberine by clonogenic cell survival assay. KYSE30 and KYSE450 cells were exposed to berberine (15 µM) or vehicle control (DMSO) for 24 and 48 h, respectively, before they were irradiated and plated.
Chunyan Hao (346539) +11 more
core +1 more source
Cancer Nexus, EarlyView.ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang +4 more
wiley +1 more source
Antisecretory effects of berberine in rat ileum [PDF]
, 1981 The in vitro antisecretory effects of the alkaloid berberine (1.0 mM) on intestinal ion secretion and mucosal adenylate cyclase and Na-K-ATPase activities were studied in the rat ileum. Mucosal berberine did not alter the individual basal net ion fluxes
Y. H. Tai +3 more
core +1 more source