Results 81 to 90 of about 39,868 (244)
Screening of isoquinoline alkaloids for potent lipid metabolism modulation with Caenorhabditis elegans. [PDF]
, 2013 Metabolic syndrome and related disorders are increasingly prevalent in contemporary society, and thus pose the need for potent agents to control lipid accumulation in the body.
Chow, Yit-Lai, Sato, Fumihiko
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Recent progress on stimuli‐responsive chitosan‐based biomaterials as drug carriers
Interdisciplinary Medicine, EarlyView.This review discusses the recent progress in chitosan‐based drug delivery systems that respond to pH, redox, enzymes, reactive oxygen species, and combined stimuli. It examines design strategies, key mechanisms, and therapeutic applications, and also addresses current challenges while suggesting future approaches to enhance clinical translation and ...
Changlu Xu +4 more
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S-adenosyl-l-methionine: (S) -7,8,13, 14-tetrahydroberberine--n-methyltransferase, a branch point enzyme in the biosynthesis of benzophenanthridine and protopine alkaloids. [PDF]
, 1986 The enzyme which transfers the CH3-group of S-adenosylmethionine to the nitrogen atom of (S)-tetrahydroberberine and (S)-stylopine is found to occur in a number of plant cell cultures originating from species containing alkaloids; it is located at an ...
Amann +8 more
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Med Research, EarlyView.White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang +12 more
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Berberine was neuroprotective against an in vitro model of brain ischemia: Survival and apoptosis pathways involved [PDF]
, 2014 Berberine is an alkaloid derived from herb the Berberis sp. and has long-term use in Oriental medicine. Studies along the years have demonstrated its beneficial effect in various neurodegenerative and neuropsychiatric disorders. The subject of this study
Simões Pires, Elisa Nicoloso +4 more
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Phytochemical Analysis, EarlyView.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
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Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature [PDF]
, 2017 The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper.
Busardò, F. P +6 more
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AMPK:a cellular energy sensor primarily regulated by AMP [PDF]
, 2014 AMPK (AMP-activated protein kinase) is a cellular energy sensor that monitors the ratio of AMP/ATP, and possibly also ADP/ATP, inside cells. Once activated by falling cellular energy levels, it acts to restore energy homoeostasis by switching on ...
Gowans, Graeme J., Hardie, D. Grahame
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Formation and Conformation of Baicalin–Berberine and Wogonoside–Berberine Complexes
Chemical and Pharmaceutical Bulletin, 2012 It is well-known that baicalin-berberine complex (1) precipitates in the water decoction of numerous Chinese Medicinal formulae containing Radix Scutellariae and Rhizoma Coptidis or Cortex Phellodendri. In the current study, ionic interaction between the carboxylate ion of baicalin and the quaternary ammonium ion of berberine was revealed to be ...
Jing-Rong, Wang +4 more
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Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, EarlyView.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
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