Results 31 to 40 of about 28,920 (238)

Preparation of Berberine@carbon Dots Nano-Formulation: Synthesis, Characterization and Herbicidal Activity against Echinochloa crus-galli and Amaranthus retroflexus Two Common Species of Weed

Nanomaterials, 2022
Berberine (Ber) is easy to synthesize and has a variety of biological and pharmacological activities. At present, the existing studies on berberine have focused predominantly on its antibacterial activity; its herbicidal activity is rarely reported.
Junhu Xu, Shuang Rong, Ziqi Qin, Guangmao Shen, Yan Wu, Zan Zhang, Kun Qian   +6 more
doaj   +1 more source

Berberine Induces Apoptosis in p53-Null Leukemia Cells by Down-Regulating XIAP at the Post-Transcriptional Level

Cellular Physiology and Biochemistry, 2013
Background: Berberine exerts anticancer activities both in vitro and in vivo through different mechanisms. However, the underlying molecular mechanisms of berberine induced p53-independent apoptosis remain unclear.
Jian Liu, Xiaoling Zhang, Aiguo Liu, Shuangyou Liu, Liuqing Zhang, Bei Wu, Qun Hu   +6 more
doaj   +1 more source

Profiling the Complexity of Resistance Factors in Cancer Cells Towards Berberine and Its Derivatives

Pharmaceuticals
Background: Berberine, a benzylisoquinoline alkaloid, has been traditionally used in Ayurvedic and Chinese medicine. We examined the resistance mechanisms to berberine in a panel of different cancer cells and focused on understanding its molecular ...
Nadire Özenver, Nadeen T. Ali, Rümeysa Yücer, Xiao Lei, Gerhard Bringmann, Thomas Efferth, Mona Dawood   +6 more
doaj   +1 more source

Isolation and Characterization of the Genes Involved in the Berberine Synthesis Pathway in Asian Blue Cohosh, Caulophyllum robustum

Plants, 2023
Caulophyllum robustum, commonly named Asian blue cohosh, is a perennial herb in the family Berberidaceae. It has traditionally been used for folk medicine in China. We isolated berberine from the leaves, stem, roots, and fruits of C.
Nam-Il Park, Neha Samir Roy, Yeri Park, Beom-Soon Choi, Mi Jin Jeon, Ji Yeon Oh, Bo-Yun Kim, Young-Dong Kim, Yong-In Kim, Taeyoung Um, Hwan Jong Kwak, Nam-Soo Kim, Soonok Kim, Ik-Young Choi   +13 more
doaj   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Label‐Free and Immobilization‐Free Protein‐Binding Assays by Ultraviolet Transient Absorption Microscopy

Advanced Science, EarlyView.
A femtosecond UV pump–probe microscope resolves binding‐induced changes in protein excited‐state dynamics and converts these intrinsic contrasts into an equilibrium affinity readout. By probing tryptophan responses directly in solution, the approach enables quantitative determination of dissociation constants without labeling or immobilization ...
Jianghao Shen, Qiangqiang Wang, Fan Wu, Yang Gao, Lu Lan, Pu Wang   +5 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Pharmacokinetic incompatibility of the Huanglian-Gancao herb pair

BMC Complementary Medicine and Therapies, 2020
Background Pharmacokinetic interaction is one of the most important indices for the evaluation of the compatibility of herbal medicines. Both Gancao (Glycyrrhizae Radix et Rhizoma) and Huanglian (Coptidis Rhizoma) are commonly used traditional Chinese ...
Ji-Quan Zhang, Rui Wang, Ting Zhou, Qing Zhao, Chun-Cao Zhao, Bing-Liang Ma   +5 more
doaj   +1 more source

Inhibitory effects and oxidative damages in Cladophora sp. (Cladophoraceae) exposed to berberine

Aquaculture Reports, 2022
Cladophora members are present in seawater and freshwater ecosystems worldwide. Their growth poses a serious threat to water environment, fisheries, production and living.
Yongtao Tang, Luping Wang, Liangjie Zhao, Chen Qian, Feng Lun, Chen Wang, Hui Zheng, Boping Tang, Yongxu Cheng, Xusheng Guo   +9 more
doaj   +1 more source

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, EarlyView.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source