Results 71 to 80 of about 20,525 (171)

Rutin Stabilises β‐Catenin Through GSK3β Inhibition to Promote Hair Follicle Regeneration

Cell Proliferation, EarlyView.
Rutin directly binds to GSK3β, stabilising β‐catenin and activating Wnt/β‐catenin signalling to drive hair cycle.
Yanyan Zhang, Yuanjie Zhu, Mengyu Jin, Jing Chen, Siqi Yuan, Minjia Yuan, Yuou Sha, Qingmei Liu, Wenyu Wu, Juan Wang, Xiaolei Ding   +10 more
wiley   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, EarlyView.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Berberine produces antidepressant-like effects in ovariectomized mice

Scientific Reports, 2017
Berberine has been reports to have antidepressant-like effects. However, it is seldom known whether berberine produces antidepressant-like effects in ovariectomized mice, which exhibit depressive-like responses. To examine the antidepressant-like effects
Jie Fan, Bingjin Li, Tongtong Ge, Zhuo Zhang, Jiayin Lv, Jing Zhao, Pu Wang, Wei Liu, Xuefeng Wang, Katarzyna Mlyniec, Ranji Cui   +10 more
doaj   +1 more source

Berberine reduces cAMP-induced chloride secretion in T84 human colonic carcinoma cells through inhibition of basolateral KCNQ1 channels

Frontiers in Physiology, 2011
Berberine is a plant alkaloid with multiple pharmacological actions, including antidiarrhoeal activity and has been shown to inhibit Cl- secretion in distal colon.
Rodrigo eAlzamora, Fiona eO'Mahony, Wing-Hung eKo, Tiffany Wai-Nga Yip, Derek eCarter, Mustapha eIrnaten, Brian Joseph Harvey   +6 more
doaj   +1 more source

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

Cell Proliferation, EarlyView.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge, Chenxiang Zhang, Yilong Zhao, Haiyang Zhao, Shuai Zhu, Tao Tang, Guorui Zhang, Qiang Wang, Hui Wang   +8 more
wiley   +1 more source

Natural‐based antioxidants in cosmeceuticals: Extraction, bioavailability and skin ageing applications

International Journal of Cosmetic Science, EarlyView.
Natural antioxidants from plants, fruits, seeds and fungi combat ageing by neutralizing free radicals, boosting collagen and protecting against UV damage. Enhanced by green extraction and smart delivery systems, they offer powerful anti‐inflammatory and antimicrobial benefits.
Hossein Omidian, Arnavaz Akhzarmehr, Charise Dallazem Bertol   +2 more
wiley   +1 more source

Nano-Encapsulated Berberine Is a Potential Therapeutic Agent for Adipose Tissue Browning in C57BL/6J Mice

Medicina
Background and Objectives: Berberine is a promising phytochemical for obesity prevention due to its effects on adipogenesis and adipose tissue browning.
Aslıhan Alpaslan, Kübra Uçar Baş, Elif Didem Örs Demet, Dilem Tuğal Aslan, Tuba Reçber, Süleyman Can Öztürk, Tugba Gulsun, Mustafa Çelebier, Zeynep Göktaş   +8 more
doaj   +1 more source

Impact of Diet and Drugs on Fecal Lachnoclostridium Gene Marker (m3) in Non‐Invasive Diagnosis of Colorectal Neoplasia

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background A novel bacterial gene marker, Lachnoclostridium (m3), has potential for non‐invasive diagnosis of colorectal cancer (CRC) and adenoma. Aim This study aims to determine the diagnostic performance of m3 in a multi‐center cohort and to examine the effect of diet and drugs on fecal m3 in subjects with colorectal neoplasia. Methods In a
Min Dai, Louis H. S. Lau, Haiyun Shi, Yang Sun, Xiaobo Li, Mengbin Li, Hui Wang, Raphaela I. Lau, Jessie Q. Y. Liang, Francis K. L. Chan, Siew C. Ng   +10 more
wiley   +1 more source

AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

Journal of Integrative Plant Biology, EarlyView.
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu   +5 more
wiley   +1 more source

Convergence and parallelism in the evolution of plant metabolism

Journal of Integrative Plant Biology, EarlyView.
Similar traits in different organisms may originate from shared ancestry or evolve independently. The terminology used to define phenotypic similarity is often confusing. This review attempts to clarify the definitions and present examples from plant domestication and specialized metabolism to explain how complex traits evolve repeatedly in plants ...
Federico Scossa, Mustafa Bulut, Thomas Naake, John C. D'Auria, Alisdair R. Fernie   +4 more
wiley   +1 more source