Results 161 to 170 of about 15,581 (231)

The BET bromodomain inhibitor ZEN-3365 targets the Hedgehog signaling pathway in acute myeloid leukemia. [PDF]

Ann Hematol, 2021
Wellbrock J, Behrmann L, Muschhammer J, Modemann F, Khoury K, Brauneck F, Bokemeyer C, Campeau E, Fiedler W.   +8 more
europepmc   +1 more source

BET-bromodomain Inhibitor ODM-207 [PDF]

, 2020
openaire   +1 more source

Structural characterisation of BET family bromodomain interactions

, 2022
Elegant mechanisms of gene regulation have evolved to support specialised function and complexity in eukaryotes. Covalent post-translational modifications (PTMs) shape the genome and direct transcriptional programs through distinct mechanisms that operate well beyond the coding capacity of DNA.
openaire   +1 more source

Efficacy and Toxicity Analysis of Selective BET Bromodomain Inhibitors in Models of Inflammatory Liver Disease. [PDF]

J Med Chem
Doskey LC, Scholtz CR, Vail NR, Khanal S, Lee AL, Kandanur SGS, Hoell ZJ, Huehls AM, Issa MR, Kostallari E, Cao S, Reid JM, Shah VH, Malhi H, Pomerantz WCK.   +14 more
europepmc   +1 more source

Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides. [PDF]

J Am Chem Soc
Kashyap D, Cadeddu M, Oliver PL, Milne TA, Booth MJ.   +4 more
europepmc   +1 more source

Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement*. [PDF]

Angew Chem Int Ed Engl, 2021
Cui H, Divakaran A, Pandey AK, Johnson JA, Zahid H, Hoell ZJ, Ellingson MO, Shi K, Aihara H, Harki DA, Pomerantz WCK.   +10 more
europepmc   +1 more source

Combination of PSMA targeting alpha-emitting radioligand [²¹²Pb]Pb-AB001 with BET bromodomain inhibitors in in vitro prostate cancer models. [PDF]

Med Oncol
Liukaityte R, Stenberg VY, Kleinauskas A, Juzenas P, Urbanucci A, Juzeniene A.   +5 more
europepmc   +1 more source

BET bromodomain inhibitors attenuate transcription of a subset of IL-1-induced NF-κB targets that promote inflammation in β-cells. [PDF]

J Biol Chem
Nord JA, Makowski SJ, Sidlowski PFW, Bursch KL, Corbett JA, Smith BC.   +5 more
europepmc   +1 more source

BET bromodomain inhibitor (JQ1) and tumor angiogenesis

Oncoscience, 2016
Bid, Hemant Kumar, Kerk, Samuel
openaire   +2 more sources