Results 161 to 170 of about 1,696,062 (260)

The extra-terminal domain drives the role of BET proteins in transcription. [PDF]

Nucleic Acids Res
Pasionek I, Ridenour JB, Machowska A, Donczew M, Kinter MT, Boyd KA, Donczew R.   +6 more
europepmc   +1 more source

Dissection of biophysical properties and biological activities of Bet/RecT family DNA recombination proteins

, 2014
Single strand DNA annealing proteins (SSAPs) of viral/phage origin play a variety of roles in homologous recombination-based DNA repair and genetic exchange processes in prokaryotes.
Watt, RM, Huang, J, Cheng, T, Chen, W
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma. [PDF]

Mol Cancer Ther, 2021
Shigeta S, Lui GYL, Shaw R, Moser R, Gurley KE, Durenberger G, Rosati R, Diaz RL, Ince TA, Swisher EM, Grandori C, Kemp CJ.   +11 more
europepmc   +1 more source

Modulation of Bromo- and Extra-Terminal Domain (BET) Proteins Exerts Neuroprotective Effects in Cell Culture Models of Parkinson's Disease. [PDF]

Biomedicines
Martella N, Pensabene D, Colardo M, Muzzi M, Bisesto E, Varone M, Caretti G, Di Porzio A, Barrella V, Mazzoli A, Di Bartolomeo S, Moreno S, Segatto M.   +12 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Development of cell-active BRD4-D1 selective inhibitors to decode the role of BET proteins in LPS-mediated liver inflammation. [PDF]

Eur J Med Chem
Scholtz CR, Doskey LC, Kandanur SGS, Vail NR, Roderick ER, Peterson EJ, Hoell ZJ, Shi K, Aihara H, Kostallari E, Shah VH, Malhi H, Pomerantz WCK.   +12 more
europepmc   +1 more source

Bet- und Lehrhaus Petriplatz Berlin

BET- UND LEHRHAUS PETRIPLATZ BERLIN Bet- und Lehrhaus Petriplatz Berlin (Rights reserved) Ausgabe [1] Ausschreibung (Rights ...

core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source