Results 141 to 150 of about 43,525 (155)

Role of BET proteins in castration-resistant prostate cancer

Drug Discovery Today: Technologies, 2016
Castration resistant prostate cancer (CRPC) is a deadly disease with few therapeutic options once patients become resistant to second generation drugs targeting the AR-transcriptional program. The BET-BRD readers of chromatin are key regulators of AR-, ERG-, and c-Myc-mediated transcription in CRPC.
Ester, Fernandez-Salas, Shaomeng, Wang, Arul M, Chinnaiyan   +2 more
openaire   +2 more sources

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Nature, 2020
Proteins of the bromodomain and extra-terminal (BET) domain family are epigenetic readers that bind acetylated histones through their bromodomains to regulate gene transcription. Dual-bromodomain BET inhibitors (DbBi) that bind with similar affinities to the first (BD1) and second (BD2) bromodomains of BRD2, BRD3, BRD4 and BRDt have displayed modest ...
Emily J, Faivre, Keith F, McDaniel, Daniel H, Albert, Srinivasa R, Mantena, Joshua P, Plotnik, Denise, Wilcox, Lu, Zhang, Mai H, Bui, George S, Sheppard, Le, Wang, Vasudha, Sehgal, Xiaoyu, Lin, Xiaoli, Huang, Xin, Lu, Tamar, Uziel, Paul, Hessler, Lloyd T, Lam, Richard J, Bellin, Gaurav, Mehta, Steve, Fidanze, John K, Pratt, Dachun, Liu, Lisa A, Hasvold, Chaohong, Sun, Sanjay C, Panchal, John J, Nicolette, Stacey L, Fossey, Chang H, Park, Kenton, Longenecker, Lance, Bigelow, Maricel, Torrent, Saul H, Rosenberg, Warren M, Kati, Yu, Shen   +33 more
openaire   +2 more sources

Therapeutic targeting of BET protein BRD4 delays murine lupus

International Immunopharmacology, 2015
BRD4 is a member of the BET (bromodomain and extraterminal domain) family proteins that can bind acetylated histones and influence transcription, which are considered as potential therapeutic targets in many distinct diseases. And the BET inhibitor JQ1 has been proven to be effective in suppressing multiple inflammatory and autoimmune diseases.
Shitong, Wei, Yonghua, Sun, Hongyu, Sha
openaire   +2 more sources

Role of BET-proteins in the function of rhadinoviral Orf73-proteins

2011
[no abstract]
openaire   +1 more source

[The research progress of foamy virus Bet protein].

Bing du xue bao = Chinese journal of virology, 2012
Foamy virus can establish lifelong persistent infection in mammal hosts without inducing diseases. Such special characteristic stimulates the interests of researchers. As reported, the accessory protein Bet of foamy virus could regulate the gene expression and infection cycle of foamy virus and take part in the generation of chronic viral infection ...
Yuan, Gao, Yan, Sun, Zhi, Li, Qing-Mei, Liu, Wan-Hong, Liu, Xiao-Hua, He   +5 more
openaire   +1 more source

BET proteins loop and compartmentalize the 3D genome

Nature Genetics, 2022
openaire   +2 more sources

Progress in the development of domain selective inhibitors of the bromo and extra terminal domain family (BET) proteins

European Journal of Medicinal Chemistry, 2021
Haiying Sun
exaly  

Killing pluripotent stem cells by BET protein inhibition

Science Bulletin, 2018
Shufeng, Ma, Ying, Lin, Zhili, Rong
openaire   +2 more sources

Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia

Biochemical and Biophysical Research Communications, 2018
Kelly M Demars, Changjun Yang, Carolina I Castro-Rivera   +2 more
exaly  

Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke

Neurochemistry International, 2019
Kelly M Demars, Changjun Yang, Eduardo Candelario-Jalil   +2 more
exaly