Results 131 to 140 of about 43,525 (155)
An epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells. [PDF]
Sci Rep, 2019 Xavier PLP +7 more
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The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins [PDF]
International Journal of Molecular Sciences, 2016 The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by the presence of two tandem bromodomains and an extra-terminal domain.
Yasushi Taniguchi
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Emerging roles of BET proteins in transcription and co‐transcriptional RNA processing [PDF]
Wiley Interdisciplinary Reviews RNA, 2023 Transcription by RNA polymerase II (Pol II) gives rise to all nuclear protein-coding and a large set of non-coding RNAs, and is strictly regulated and coordinated with RNA processing.
Nicole Eischer, Andreas Mayer
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Histone acetylation, BET proteins, and periodontal inflammation
Molecular Oral Microbiology, 2023AbstractPeriodontitis is one of the most common inflammatory diseases in humans. The susceptibility to periodontitis is largely determined by the host response, and the severity of inflammation predicts disease progression. Upon microbial insults, host cells undergo massive changes in their transcription program to trigger an appropriate response ...
Nicholas, Clayton +2 more
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BET proteins: Biological functions and therapeutic interventions
Pharmacology & Therapeutics, 2023Bromodomain and extra-terminal (BET) family member proteins (BRD2, BRD3, BRD4 and BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac modification, thus controlling gene expression, remodeling chromatin structures and avoid replicative stress-induced DNA damages.
Jiawei Guo
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Role of bromodomain and extraterminal (BET) proteins in prostate cancer
Expert Opinion on Investigational Drugs, 2023The bromodomain and extraterminal (BET) family of proteins are epigenetic readers of acetylated histones and are critical activators of oncogenic networks across many cancers. Therapeutic targeting of BET proteins has been an attractive area of clinical development for metastatic castration-resistant prostate cancer.
Adel Mandl +3 more
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Targeting BET bromodomain proteins in cancer: The example of lymphomas
Pharmacology & Therapeutics, 2020The Bromo- and Extra-Terminal domain (BET) family proteins act as "readers" of acetylated histones and they are important transcription regulators. BRD2, BRD3, BRD4 and BRDT, part of the BET family, are important in different tumors, where upregulation or translocation often occurs.
Spriano F, Stathis A, Bertoni F
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Alternative Mechanisms for DNA Engagement by BET Bromodomain-Containing Proteins
Biochemistry, 2022Epigenetic reader domains regulate chromatin structure and modulate gene expression through the recognition of post-translational modifications on histones. Recently, reader domains have also been found to harbor double-stranded (ds) DNA-binding activity, which is as functionally critical as histone association.
Prakriti Kalra +4 more
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Small-Molecule Targeting of BET Proteins in Cancer
2016BET proteins have recently become recognized for their role in a broad range of cancers and are defined by the presence of two acetyl-histone reading bromodomains and an ET domain. This family of proteins includes BRD2, BRD3, BRD4, and BRDT. BRD4 is the most-studied BET protein in cancer, and normally serves as an epigenetic reader that links active ...
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