Results 111 to 120 of about 1,696,062 (260)

Luck or Skill? An Examination of the Ehrlich - Simon Bet [PDF]

In 1980, Paul Ehrlich and Julian Simon placed a famous bet on whether the prices of a bundle of natural resources would rise or fall over the ensuing decade. Simon won the bet as the real price of the bundle fell significantly, and the result of this bet
Kevin Golembiewski, Katherine A. Kiel, Victor Matheson   +2 more
core  

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer

, 2017
Triple-negative breast cancers (TNBC) remain clinically challenging with a lack of options for targeted therapy. In this study, we report the development of a second-generation BET protein degrader, BETd-246, which exhibits superior selectivity, potency,
Longchuan Bai, Hui Jiang, Jeanne Stuckey, Matthew J. Ellis, Bo Wen, Fuming Xu, Yali Dou, Bing Zhou, Donna McEachern, Ester Fernandez-Salas, Jiantao Hu, Jiao Ji, Yujun Zhao, Jing Xu, Sally Przybranowski, Shaomeng Wang, Duxin Sun, Jennifer Meagher, Liu Liu, Daniel F. Hayes, Shunqiang Li, Chao-Yie Yang   +21 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Novel BD2-Selective Inhibitor of BRDs Mitigates ROS Production and OA Pathogenesis

Antioxidants
Bromodomain and extra-terminal domain (BET) family proteins regulate transcription and recognize lysine residues in histones. Selective BET inhibitors targeting one domain have attracted attention because they maintain normal physiological activities ...
Hyemi Lee, Jihye Choe, Min-Hee Son, In-Hyun Lee, Min Ju Lim, Jimin Jeon, Siyoung Yang   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Reactivity of primate sera to foamy virus Gag and Bet proteins [PDF]

, 1994
In order to establish criteria for the Serodiagnosis of foamy virus infections we investigated the extent to which sera from iofected individuals of human and primate origin react with structural and non-structural virus proteins in immunoblot assays ...
Baunach, Gerald, Bräutigam, Sandra, McClure, Myra O., Neumann-Haefelin, Dieter, Hahn, Heidi, Daniel, Muthiah D., Rethwilm, Axel, Mergia, Ayalew   +7 more
core   +2 more sources

[News Clip: Another Election Bet]

, 1960
Video footage from the WBAP-TV television station in Fort Worth, Texas, to accompany a news story about a lost bet where Carl Thompson has to push a peanut one block from the drug store to the grocery ...
WBAP-TV (Television station : Fort Worth, Tex.)
core   +1 more source

BET bromodomain proteins are required for glioblastoma cell proliferation

, 2014
Epigenetic proteins have recently emerged as novel anticancer targets. Among these, bromodomain and extra terminal domain (BET) proteins recognize lysine-acetylated histones, thereby regulating gene expression.
Volmar, Claude-Henry, Graham, Regina M, Penas, Clara, Daniel, Mark, Ayad, Nagi G, Johnstone, Andrea L, Wahlestedt, Claes, Pastori, Chiara, Allen, Bryce, Komotar, Ricardo J, Brothers, Shaun P, Sarkaria, Jann N   +11 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML. [PDF]

Clin Cancer Res, 2023
Letson CT, Balasis ME, Newman H, Binder M, Vedder A, Kinose F, Ball M, Kruer T, Quintana A, Lasho TL, Finke CM, Almada LL, Grants JM, Zhang G, Fernandez-Zapico ME, Gaspar-Maia A, Lancet J, Komrokji R, Haura E, Sallman DA, Reuther GW, Karsan A, Rix U, Patnaik MM, Padron E.   +24 more
europepmc   +1 more source