Results 91 to 100 of about 43,525 (155)

BET Bromodomain Proteins Are Therapeutic Targets in CRPC [PDF]

Cancer Discovery, 2014
Abstract Small-molecule inhibitors of BET family proteins retard progression of AR-dependent CRPC.
openaire   +1 more source

BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment

, 2017
Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory factors influence transcription elongation on a global scale.
Olson, C., Kelliher, M., Erb, M., Souza, A., di Iulio, J., Roderick, J., Paulk, J., Gray, N., Lachance, K., Scott, T., Roberts, J., Winter, G., Bradner, J., Buckley, D., Vittori, S., Bauer, S., Reyes,, J., Zeid, R., Churchman, L., Dastjerdi, S., Lin, C., Ott, C., Mayer, A.   +22 more
core   +2 more sources

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 [PDF]

, 2017
The bromodomain and extra-terminal (BET) family of proteins, comprised of four members including BRD2, BRD3, BRD4 and the testis-specific isoform BRDT, largely function as transcriptional co-activators 1–3 and play critical roles in various cellular ...
Andrew H Beck, Pengda Liu, Huang, Jiaoti, Muthuswamy, Senthil, Rubin, Mark A., Kwok-Kin Wong, Ling Huang, Jiaoti Huang, Divya Vasudevan, Barbieri, Christopher E, Xiangpeng Dai, Xiaoning Li, James E Bradner, Christopher E Barbieri, Liu, Shengwu, Qing Zhong, Vasudevan, Divya, Hiroyuki Inuzuka, Shimizu, Kouhei, Ting Chen, Wong, Kwok-Kin, Francisco Beca, Beck, Andrew, Mark A Rubin, Dai, Xiangpeng, Liewei Wang, Wild, Peter J, Rubin, Mark A, Dennis L Buckley, Rubin, Mark Andrew, Qi, Jun, Wei, Wenyi, Garraway, Levi A, Chen, Ting, Senthil K Muthuswamy, Wenyi Wei, Guo, Jianping, Beck, Andrew H, Inuzuka, Hiroyuki, Yu Chen, Buser, Lorenz, Lorenz Buser, Shangqian Wang, Wang, Shangqian, Wang, Liewei, Muthuswamy, Senthil K, Wild, Peter J., Shengwu Liu, Zhang, Jinfang, Barbieri, Christopher E., Bradner, James E, Jinfang Zhang, Wei Zhang, Mirjam Blattner, Zhang, Wei, Huang, Ling, Li, Xiaoning, Levi A Garraway, Buckley, Dennis L., Wenjian Gan, Chen, Yu, Kouhei Shimizu, Buckley, Dennis L, Blattner, Mirjam, Peter J Wild, Zhong, Qing, Garraway, Levi, Beca, Francisco, Liu, Pengda, Jianping Guo, Jun Qi, Gan, Wenjian   +71 more
core   +1 more source

Image_3_Targeting BET Proteins With a PROTAC Molecule Elicits Potent Anticancer Activity in HCC Cells.TIF

, 2020
Background and Aim: Bromodomain and extraterminal domain (BET) family proteins are epigenetic regulators involved in human malignances. Targeting BET proteins for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing ...
Yi Zhang (9093), Jiakai Zhang (3825760), Huapeng Zhang (4871578), Zhihui Wang (88248), Bing Yan (170259), Sanyang Chen (8294529), Wenzhi Guo (3825748), Hongwei Tang (129296), Jihua Shi (8294526), Shuijun Zhang (294875), Chun Pang (573965), Gongquan Li (294877), Jie Li (15030), Peihao Wen (3825751)   +13 more
core   +1 more source

RAPID resistance to BET inhibitors is mediated by FGFR1 in glioblastoma

Scientific Reports
Bromodomain and extra-terminal domain (BET) proteins are therapeutic targets in several cancers including the most common malignant adult brain tumor glioblastoma (GBM). Multiple small molecule inhibitors of BET proteins have been utilized in preclinical
Anna M. Jermakowicz, Alison M. Kurimchak, Katherine J. Johnson, Florence Bourgain-Guglielmetti, Simon Kaeppeli, Maurizio Affer, Hari Pradhyumnan, Robert K. Suter, Winston Walters, Maria Cepero, James S. Duncan, Nagi G. Ayad   +11 more
doaj   +1 more source

A Novel BD2-Selective Inhibitor of BRDs Mitigates ROS Production and OA Pathogenesis

Antioxidants
Bromodomain and extra-terminal domain (BET) family proteins regulate transcription and recognize lysine residues in histones. Selective BET inhibitors targeting one domain have attracted attention because they maintain normal physiological activities ...
Hyemi Lee, Jihye Choe, Min-Hee Son, In-Hyun Lee, Min Ju Lim, Jimin Jeon, Siyoung Yang   +6 more
doaj   +1 more source

BET bromodomain proteins regulate immune checkpoints through both AMPK-dependent and independent pathways [PDF]

, 2020
Immune exhaustion can be a major clinical problem for patients who have cancer or chronic inflammation. Persistent antigen stimulation drives T cells to express multiple surface markers called immune checkpoints.
Huang, Kunlin
core  

Image_2_Targeting BET Proteins With a PROTAC Molecule Elicits Potent Anticancer Activity in HCC Cells.TIF

, 2020
Background and Aim: Bromodomain and extraterminal domain (BET) family proteins are epigenetic regulators involved in human malignances. Targeting BET proteins for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing ...
Yi Zhang (9093), Jiakai Zhang (3825760), Huapeng Zhang (4871578), Zhihui Wang (88248), Bing Yan (170259), Sanyang Chen (8294529), Wenzhi Guo (3825748), Hongwei Tang (129296), Jihua Shi (8294526), Shuijun Zhang (294875), Chun Pang (573965), Gongquan Li (294877), Jie Li (15030), Peihao Wen (3825751)   +13 more
core   +1 more source

BET bromodomain proteins [PDF]

Science-Business eXchange, 2014
openaire   +3 more sources

Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML. [PDF]

Clin Cancer Res, 2023
Letson CT, Balasis ME, Newman H, Binder M, Vedder A, Kinose F, Ball M, Kruer T, Quintana A, Lasho TL, Finke CM, Almada LL, Grants JM, Zhang G, Fernandez-Zapico ME, Gaspar-Maia A, Lancet J, Komrokji R, Haura E, Sallman DA, Reuther GW, Karsan A, Rix U, Patnaik MM, Padron E.   +24 more
europepmc   +1 more source