Results 101 to 110 of about 43,525 (155)

Abstract LB-099: BET bromodomain proteins are essential for the oncogenic EWS-fusion driven Ewing Sarcoma

, 2017
Ewing sarcoma (EWS) is a lethal pediatric small, round, blue cell tumor defined by the characteristic fusion between EWSR1 and a member of the ETS family transcription factor, mostly FLI1 and ERG. Bromodomain and extra-terminal domain (BET) proteins play
Vijaya L. Dommeti, Archana Nallasivam, Felix Y. Feng, Aishwarya Pawar, Ingrid A. Apel, Zhaohui S. Qin, Kari Wilder-Romans, Paradesi N. Gollavilli, Tianlei Xu, Irfan A. Asangani, Carl Engelke, Pranathi M. Krishnamurthy   +11 more
core   +1 more source

Image_1_Targeting BET Proteins With a PROTAC Molecule Elicits Potent Anticancer Activity in HCC Cells.TIF

, 2020
Background and Aim: Bromodomain and extraterminal domain (BET) family proteins are epigenetic regulators involved in human malignances. Targeting BET proteins for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing ...
Yi Zhang (9093), Jiakai Zhang (3825760), Huapeng Zhang (4871578), Zhihui Wang (88248), Bing Yan (170259), Sanyang Chen (8294529), Wenzhi Guo (3825748), Hongwei Tang (129296), Jihua Shi (8294526), Shuijun Zhang (294875), Chun Pang (573965), Gongquan Li (294877), Jie Li (15030), Peihao Wen (3825751)   +13 more
core   +1 more source

Inhibition of BET Proteins Regulates Fcγ Receptor Function and Reduces Inflammation in Rheumatoid Arthritis. [PDF]

Int J Mol Sci, 2023
Shankar D, Merchand-Reyes G, Buteyn NJ, Santhanam R, Fang H, Kumar K, Mo X, Ganesan LP, Jarjour W, Butchar JP, Tridandapani S.   +10 more
europepmc   +1 more source

Dissection of biophysical properties and biological activities of Bet/RecT family DNA recombination proteins

, 2014
Single strand DNA annealing proteins (SSAPs) of viral/phage origin play a variety of roles in homologous recombination-based DNA repair and genetic exchange processes in prokaryotes.
Watt, RM, Huang, J, Cheng, T, Chen, W
core  

The Role of Bromodomain and Extraterminal (BET) Proteins in Controlling the Phagocytic Activity of Microglia In Vitro: Relevance to Alzheimer's Disease. [PDF]

Int J Mol Sci, 2022
Matuszewska M, Cieślik M, Wilkaniec A, Strawski M, Czapski GA.   +4 more
europepmc   +1 more source

High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly. [PDF]

Elife, 2023
Berryer MH, Rizki G, Nathanson A, Klein JA, Trendafilova D, Susco SG, Lam D, Messana A, Holton KM, Karhohs KW, Cimini BA, Pfaff K, Carpenter AE, Rubin LL, Barrett LE.   +14 more
europepmc   +1 more source

Bromodomain Protein Inhibition Protects β-Cells from Cytokine-Induced Death and Dysfunction via Antagonism of NF-κB Pathway

Cells
Cytokine-induced β-cell apoptosis is a major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding its underlying mechanisms, few drugs have been translated to protect β-cells in T1D.
Vinny Negi, Jeongkyung Lee, Varun Mandi, Joseph Danvers, Ruya Liu, Eliana M. Perez-Garcia, Feng Li, Rajaganapati Jagannathan, Ping Yang, Domenic Filingeri, Amit Kumar, Ke Ma, Mousumi Moulik, Vijay K. Yechoor   +13 more
doaj   +1 more source

The Role of BET Proteins on M1/M2 Macrophage Polarization

The main curative treatment for hematologic malignancies, such as leukemias, is an allogeneic hematopoietic stem cell transplantation. However, graft-versus-host disease (GVHD) is a leading cause of mortality in these patients.
Surana, Simran
core  

Intrinsic BET inhibitor resistance in prostate cancer caused by SPOP mutation-mediated BET protein stabilization

, 2017
Bromodomain and extraterminal domain (BET) protein inhibitors are emerging as promising anti-cancer therapies. The gene encoding the E3 ubiquitin ligase substrate-binding adaptor speckle-type POZ protein (SPOP) is most frequently mutated in prostate cancer.
Zhang, Pingzhao, Wang, Dejie, Zhao, Yu, Ren, Shancheng, Gao, Kun, Ye, Zhenqing, Wang, Shangqian, Pan, Chun-Wu, Zhu, Yasheng, Yan, Yuqian, Yang, Yinhui, Wu, Di, He, Yundong, Zhang, Jun, Lu, Daru, Liu, Xiuping, Yu, Long, Zhao, Shimin, Li, Yao, Lin, Dong, Wang, Yuzhuo, Wang, Liguo, Chen, Yu, Sun, Yinghao, Wang, Chenji, Huang, Haojie   +25 more
openaire   +1 more source

A Phase I Study of Pelabresib (CPI-0610), a Small-Molecule Inhibitor of BET Proteins, in Patients with Relapsed or Refractory Lymphoma. [PDF]

Cancer Res Commun, 2022
Blum KA, Supko JG, Maris MB, Flinn IW, Goy A, Younes A, Bobba S, Senderowicz AM, Efuni S, Rippley R, Colak G, Trojer P, Abramson JS.   +12 more
europepmc   +1 more source