Results 81 to 90 of about 43,525 (155)

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer

, 2017
Triple-negative breast cancers (TNBC) remain clinically challenging with a lack of options for targeted therapy. In this study, we report the development of a second-generation BET protein degrader, BETd-246, which exhibits superior selectivity, potency,
Longchuan Bai, Hui Jiang, Jeanne Stuckey, Matthew J. Ellis, Bo Wen, Fuming Xu, Yali Dou, Bing Zhou, Donna McEachern, Ester Fernandez-Salas, Jiantao Hu, Jiao Ji, Yujun Zhao, Jing Xu, Sally Przybranowski, Shaomeng Wang, Duxin Sun, Jennifer Meagher, Liu Liu, Daniel F. Hayes, Shunqiang Li, Chao-Yie Yang   +21 more
core   +1 more source

Structure-Function Analysis of BET Proteins in Transcription

, 2020
The widely expressed bromodomain and extraterminal motif (BET) proteins bromodomain-containing protein 2 (BRD2), BRD3, and BRD4 are multifunctional transcriptional regulators that bind acetylated chromatin via their conserved tandem bromodomains.
Werner, Michael Thomas, Werner, Michael T   +1 more
core  

BET Family Protein BRD4: An Emerging Actor in NFκB Signaling in Inflammation and Cancer

Biomedicines, 2018
NFκB (Nuclear Factor-κ-light-chain-enhancer of activated B cells) signaling elicits global transcriptional changes by activating cognate promoters and through genome-wide remodeling of cognate regulatory elements called “super enhancers”.
Azadeh Hajmirza, Anouk Emadali, Arnaud Gauthier, Olivier Casasnovas, Rémy Gressin, Mary B. Callanan   +5 more
doaj   +1 more source

Selective Inhibition of BET Protein Domains Has Functional Relevance [PDF]

Cancer Discovery, 2020
Abstract Inhibition of BET protein bromodomains BD1 and BD2 produces unique phenotypes in disease models.
openaire   +2 more sources

Stability of the Bet v 1 cross-reactive allergens Api g 1 and Dau c 1 : a biophysical approach

, 2009
The allergen Bet v 1 is known as the primary sensitizer for birch pollen-related food allergy and is responsible for IgE cross-reactivity to pathogenesis-related 10 (PR-10) proteins from, in particular, fruits from the Rosaceae and vegetables from the ...
Bollen, M.A.
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Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits BET Bromodomain Proteins

, 2016
Agents that trigger cell differentiation are highly efficacious in treating certain cancers, but such approaches are not generally effective in most malignancies.
Demir, Dagsu,, Welin, M., Walse, B., Nilsson, Lisa M,, Muralidharan, Somsundar Veppil,, Green, Lydia C.,, Logan, D. T., Nilsson, Jonas A,, Bhadury, Joydeep,   +8 more
core   +1 more source

T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects

, 2009
Lipid transfer proteins (LTPs), particularly peach Pru p 3, are the most relevant plant food allergens in the South of Europe, and, therefore, their allergic properties have been extensively studied.
Tordesillas Villuendas, Leticia, Sánchez-Monge Laguna de Rins, Rosa, Gonzalez-Muñoz, Miguel, Salcedo Duran, Gabriel, Pacios, Luis F., Compes, Esther, Díaz Perales, Araceli, Belen Garcia-Carrasco, Esther Compés, Cuesta-Herranz, Javier, Gabriel Salcedo, Rosa Sanchez-Monge, Miguel Gonzalez-Muñoz, Javier Cuesta-Herranz, Leticia Tordesillas, Garcia-Carrasco, Belen, Luis F. Pacios, Araceli Diaz-Perales   +17 more
core   +1 more source

Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

Nature Communications, 2020
Inhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targets ...
Mingzhu Yin, Ying Guo, Rui Hu, Wesley L. Cai, Yao Li, Shiyao Pei, Hongyin Sun, Cong Peng, Jiali Li, Rui Ye, Qiaohong Yang, Nenghui Wang, Yongguang Tao, Xiang Chen, Qin Yan   +14 more
doaj   +1 more source

Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma

Cell & Bioscience
Background B-cell non-Hodgkin lymphoma (B-NHL) is the most common type of lymphoma and is significantly heterogeneous among various subtypes. Despite of considerable advancements in treatment strategies for B-NHL, the prognosis of relapsed/refractory ...
Dan Zou, Sitong Feng, Bowen Hu, Mengya Guo, Yan Lv, Rong Ma, Yuxin Du, Jifeng Feng   +7 more
doaj   +1 more source

Reactivity of primate sera to foamy virus Gag and Bet proteins [PDF]

, 1994
In order to establish criteria for the Serodiagnosis of foamy virus infections we investigated the extent to which sera from iofected individuals of human and primate origin react with structural and non-structural virus proteins in immunoblot assays ...
Bräutigam, Sandra, Muthiah D. Daniel, McClure, Myra O., Myra O. Mcclure S, Neumann-Haefelin, Dieter, Gerald Baunach, Heidi Hahn, Ayalew Mergia, Baunach, Gerald, Dieter Neumann-haefel In, Hahn, Heidi, Daniel, Muthiah D., Rethwilm, Axel, Axel Rethwilm, Mergia, Ayalew   +14 more
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