Results 81 to 90 of about 1,696,062 (260)

BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition. [PDF]

Mol Cancer Res, 2018
Transcriptional programs in embryogenesis and cancer, such as the epithelial-to-mesenchymal transition (EMT), ensure cellular plasticity, an essential feature of carcinoma progression.
Andrieu GP, Denis GV.
europepmc   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

BET Family Protein BRD4: An Emerging Actor in NFκB Signaling in Inflammation and Cancer

Biomedicines, 2018
NFκB (Nuclear Factor-κ-light-chain-enhancer of activated B cells) signaling elicits global transcriptional changes by activating cognate promoters and through genome-wide remodeling of cognate regulatory elements called “super enhancers”.
Azadeh Hajmirza, Anouk Emadali, Arnaud Gauthier, Olivier Casasnovas, Rémy Gressin, Mary B. Callanan   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma [PDF]

Oncotarget, 2013
Medulloblastoma is the most common malignant brain tumor of childhood, and represents a significant clinical challenge in pediatric oncology, since overall survival currently remains under 70%. Patients with tumors overexpressing MYC or harboring a MYC oncogene amplification have an extremely poor prognosis.
Henssen, Anton, Thor, Theresa, Odersky, Andrea, Heukamp, Lukas, El-Hindy, Nicolai, Beckers, Anneleen, Speleman, Frank, Althoff, Kristina, Schäfers, Simon, Schramm, Alexander, Sure, Ulrich, Fleischhack, Gudrun, Eggert, Angelika, Schulte, Johannes   +13 more
openaire   +5 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma [PDF]

, 2018
Significance Glioblastoma (GBM) cells develop intrinsic or acquired insensitiveness to BET bromodomain inhibitors (BBIs) yet develop persistent BET protein dependency. Selective degradation of BET proteins by a next-generation chemical compound
Carol Tang, Huang, Mo-Li, Liang Xu, Koeffler, H Phillip, Mo-Li Huang, Anand Mayakonda, H. Phillip Koeffler, Wendi Sun, Xu, Liang, Benjamin P. Berman, Sandanaraj, Edwin, Beng Ti Ang, Edwin Sandanaraj, Lynnette Koh, Ke, Xin-Yu, Ling-Wen Ding, Bradner, James E, Dennis L. Buckley, Sun, Wendi, Goh, Boon Cher, Lin, Ruby Yu-Tong, See Wee Lim, Kappei, Dennis, Jianxiang Chen, Winter, Georg E, Ye Chen, Ang, Beng Ti, Berman, Benjamin P, Buckley, Dennis L, Lim, See Wee, Chen, Jianxiang, Ding, Ling-Wen, Dennis Kappei, Dinh, Huy Q, Yuk Kien Chong, Huy Q. Dinh, Wang, Ling-Zhi, Chong, Yuk Kien, James E. Bradner, Koh, Lynnette, Ling-Zhi Wang, Xin-Yu Ke, Georg E. Winter, Ruby Yu-Tong Lin, Boon Cher Goh, Chen, Ye, Mayakonda, Anand, Tang, Carol   +47 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

In Search of a Fair Bet in the Lottery [PDF]

Although state-operated lotto games have the worst average expected payoffs among common games of chance, because the jackpot can accumulate, the maximum expected payoff is potentially unlimited.
Kent Grote, Victor Matheson
core   +2 more sources