Results 61 to 70 of about 43,525 (155)

Bromodomain and extra-terminal proteins in solid tumors: regulators of immune microenvironment and emerging therapeutic targets

Frontiers in Immunology
Bromodomain and Extra-Terminal domain (BET) proteins are key epigenetic readers that recognize and bind acetylated lysine residues on histones, orchestrating transcriptional programs that drive oncogenic processes. BET proteins regulate the expression of
Deeksha Sharma, Grace G. Bushnell, Alexander P. Kalman, Chloe M. Hutchens, Monika L. Burness   +4 more
doaj   +1 more source

Intra- and Intercellular Trafficking of the Foamy Virus Auxiliary Bet Protein [PDF]

Journal of Virology, 2002
ABSTRACT The Bet protein of foamy viruses (FVs) is an auxiliary protein encoded by the 3′ end of the viral genome. Although its function during the viral replication cycle is still unknown, Bet seems to play a key role in the establishment and/or maintenance of viral persistence, representing the predominant viral protein detected during ...
Lecellier, Charles-Henri, Vermeulen, Wim, Bachelerie, Françoise, Giron, Marie-Lou, Saïb, Ali   +4 more
openaire   +4 more sources

A Minireview on BET Inhibitors: Beyond Bromodomain Targeting

Biomedicines
Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that recognize the histone acetylation code and play a critical role in regulating gene transcription.
Mikhail S. Iudin, Yuri M. Khodarovich, Anna M. Varizhuk, Vladimir B. Tsvetkov, Vyacheslav V. Severov   +4 more
doaj   +1 more source

IMMUNOTHERAPEUTIC ACTION OF T-BET GENE MODIFIED DENDRITIC CELLS [PDF]

, 2013
T-bet is a Type-1 transcription factor that regulates the development of Type-1 T cell and Type-1 anti-tumor immunity. T-bet expression in Dendritic Cells (DC) is required for the ability of these antigen-presenting cells (APC) to prime Type-1-polarized ...
Chen, Lu
core  

Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

Cells
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular mechanism of the origin and development of uLMS is limited. Bromodomain and extra-
Qiwei Yang, Ali Falahati, Azad Khosh, Ricardo R. Lastra, Thomas G. Boyer, Ayman Al-Hendy   +5 more
doaj   +1 more source

Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases

Frontiers in Pharmacology, 2019
Epigenetic mechanisms, especially DNA methylation and histone modifications, are dynamic processes that regulate the gene expression transcriptional program in normal and diseased states. The bromodomain and extraterminal (BET) protein family (BRD2, BRD3,
Jose Luis Morgado-Pascual, Jose Luis Morgado-Pascual, Sandra Rayego-Mateos, Sandra Rayego-Mateos, Lucia Tejedor, Lucia Tejedor, Beatriz Suarez-Alvarez, Beatriz Suarez-Alvarez, Marta Ruiz-Ortega, Marta Ruiz-Ortega   +9 more
doaj   +1 more source

BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations

Genes and Diseases, 2023
The bromodomain and extra-terminal (BET) proteins act as “readers” for lysine acetylation and facilitate the recruitment of transcriptional elongation complexes.
Tao Ma, Yan Chen, Zhi-Gang Yi, Yan-Hong Li, Jun Bai, Li-Juan Li, Lian-Sheng Zhang   +6 more
doaj   +1 more source

Induction of MNK Kinase–dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors [PDF]

Molecular Cancer Therapeutics, 2019
Abstract BET inhibitors (BETi), which target transcription of key oncogenic genes, are currently being evaluated in early-phase clinical trials. However, because BETis show limited single-agent activity, there is increasing interest in identifying signaling pathways to enhance the efficacy of BETis.
Thao N D, Pham, Krishan, Kumar, Brian T, DeCant, Meng, Shang, Samad Z, Munshi, Maria, Matsangou, Kazumi, Ebine, Hidayatullah G, Munshi   +7 more
openaire   +2 more sources

Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease

Cardiovascular Therapeutics, 2020
Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates with the abundance of acute phase response (APR) proteins in the liver and plasma.
Sylwia Wasiak, Dean Gilham, Emily Daze, Laura M. Tsujikawa, Christopher Halliday, Stephanie C. Stotz, Brooke D. Rakai, Li Fu, Ravi Jahagirdar, Michael Sweeney, Jan O. Johansson, Norman C. W. Wong, Ewelina Kulikowski   +12 more
doaj   +1 more source

Functions, structure, and read-through alternative splicing of feline APOBEC3 genes

, 2008
Background Over the past years a variety of host restriction genes have been identified in human and mammals that modulate retrovirus infectivity, replication, assembly, and/or cross-species transmission. Among these host-encoded restriction factors, the
Marion Battenberg, O'Brien, Stephen J., Hotz-Wagenblatt, Agnes, Battenberg, Marion, Thomas Beck, Sarah Chareza, O\u27Brien, Stephen J., Thielebein, Jens, Jörg Zielonka, Münk, Carsten, Cichutek, Klaus, Beck, Thomas W., Zielonka, Jörg, Chareza, Sarah, Bravo, Ignacio G., Beck, Thomas, Jens Thielebein, Klaus Cichutek, Ignacio G Bravo, Löchelt, Martin, Martin Löchelt, Carsten Münk, Agnes Hotz-Wagenblatt, Yuhki, Naoya, Stephen J O'Brien, Naoya Yuhki   +25 more
core   +1 more source