Results 51 to 60 of about 1,696,062 (260)

A Minireview on BET Inhibitors: Beyond Bromodomain Targeting

Biomedicines
Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that recognize the histone acetylation code and play a critical role in regulating gene transcription.
Mikhail S. Iudin, Yuri M. Khodarovich, Anna M. Varizhuk, Vladimir B. Tsvetkov, Vyacheslav V. Severov   +4 more
doaj   +1 more source

BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs [PDF]

Circulation Research, 2020
Epigenetic mechanisms involve the placing (writing) or removal (erasing) of histone modifications that allow heterochromatin to transition to the open, activated euchromatin state necessary for transcription. A third, less studied epigenetic pathway involves the reading of these specific histone marks once placed.
Patricia Cristine Borck, Lian-Wang Guo, Jorge Plutzky   +2 more
openaire   +2 more sources

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Bromodomain and extra-terminal proteins in solid tumors: regulators of immune microenvironment and emerging therapeutic targets

Frontiers in Immunology
Bromodomain and Extra-Terminal domain (BET) proteins are key epigenetic readers that recognize and bind acetylated lysine residues on histones, orchestrating transcriptional programs that drive oncogenic processes. BET proteins regulate the expression of
Deeksha Sharma, Grace G. Bushnell, Alexander P. Kalman, Chloe M. Hutchens, Monika L. Burness   +4 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

Cells
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular mechanism of the origin and development of uLMS is limited. Bromodomain and extra-
Qiwei Yang, Ali Falahati, Azad Khosh, Ricardo R. Lastra, Thomas G. Boyer, Ayman Al-Hendy   +5 more
doaj   +1 more source

BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations

Genes and Diseases, 2023
The bromodomain and extra-terminal (BET) proteins act as “readers” for lysine acetylation and facilitate the recruitment of transcriptional elongation complexes.
Tao Ma, Yan Chen, Zhi-Gang Yi, Yan-Hong Li, Jun Bai, Li-Juan Li, Lian-Sheng Zhang   +6 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases

Frontiers in Pharmacology, 2019
Epigenetic mechanisms, especially DNA methylation and histone modifications, are dynamic processes that regulate the gene expression transcriptional program in normal and diseased states. The bromodomain and extraterminal (BET) protein family (BRD2, BRD3,
Jose Luis Morgado-Pascual, Jose Luis Morgado-Pascual, Sandra Rayego-Mateos, Sandra Rayego-Mateos, Lucia Tejedor, Lucia Tejedor, Beatriz Suarez-Alvarez, Beatriz Suarez-Alvarez, Marta Ruiz-Ortega, Marta Ruiz-Ortega   +9 more
doaj   +1 more source

Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation

Biomedicines, 2023
BET proteins function as histone code readers of acetylated lysins that determine the positive regulation in transcription of genes involved in cell cycle progression, differentiation, inflammation, and many other pathways. In recent years, thanks to the
Noemi Martella, Daniele Pensabene, Michela Varone, Mayra Colardo, Michele Petraroia, William Sergio, Piergiorgio La Rosa, Sandra Moreno, Marco Segatto   +8 more
doaj   +1 more source