Results 31 to 40 of about 1,696,062 (260)
Frontiers in Molecular Biosciences, 2020 Bromodomain and extra-terminal domain (BET) family proteins have become a hot research area because of their close relationship with a variety of human diseases.
Ping Bai +9 more
doaj +1 more source
BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes [PDF]
International Journal of Molecular Sciences, 2019 Ajit shah, Peter J. Thompson
exaly +2 more sources
Epigenetics in Oncohematology: Brief Review
Клиническая онкогематология, 2015 Objective. To discuss historical aspects of epigenetics as an independent branch of biology, as well as to describe post-translational modifications of DNA and histones (PTMs) as epigenetic events. Methods.
Anton Dmitrievich Shirin +2 more
doaj +1 more source
Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators [PDF]
Cell Reports, 2019 Kareem Mohni +2 more
exaly +2 more sources
Functions of BET proteins in erythroid gene expression [PDF]
Blood, 2015 Key Points BETs promote GATA1 chromatin occupancy and subsequently activate transcription; they are generally not required for repression. BRD2 and BRD4 are essential for full GATA1 activity whereas BRD3 function overlaps with BRD2.
Aaron J, Stonestrom +10 more
openaire +2 more sources
BET Proteins: An Approach to Future Therapies in Transplantation [PDF]
American Journal of Transplantation, 2017 In order to develop new efficient therapies for organ transplantation, it is essential to acquire a comprehensive knowledge of the molecular mechanisms and processes, such as immune activation, chronic inflammation, and fibrosis, which lead to rejection and long-term graft loss.
B, Suarez-Alvarez +3 more
openaire +2 more sources
BET Protein-Mediated Transcriptional Regulation in Heart Failure [PDF]
International Journal of Molecular Sciences, 2021 Heart failure is a complex disease process with underlying aberrations in neurohormonal systems that promote dysregulated cellular signaling and gene transcription. Over the past 10 years, the advent of small-molecule inhibitors that target transcriptional machinery has demonstrated the importance of the bromodomain and extraterminal (BET) family of ...
Talha Ijaz, Michael A. Burke
openaire +2 more sources
BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. [PDF]
PLoS ONE, 2016 Displacement of Bromodomain and Extra-Terminal (BET) proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored.
Jude T Deeney +4 more
doaj +1 more source
The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands
BMC Evolutionary Biology, 2008 Background The major birch pollen allergen, Bet v 1, is a member of the ubiquitous PR-10 family of plant pathogenesis-related proteins. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified.
Breiteneder Heimo +2 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2022 BH3 mimetics are promising novel anticancer therapeutics. By selectively inhibiting BCL-2, BCL-xL, or MCL-1 (i.e. ABT-199, A-1331852, S63845) they shift the balance of pro- and anti-apoptotic proteins in favor of apoptosis.
Ufuk Erdogdu +7 more
doaj +1 more source