A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles
Frontiers in Pharmacology, 2022 Epigenetic modifications, specifically acetylation of histone plays a decisive role in gene regulation and transcription of normal cellular mechanisms and pathological conditions.
Hafiz Akbar Ali +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Bromodomain and extra-terminal domain (BET) family proteins play important roles in regulating the expression of multiple proto-oncogenes by recognizing acetylation of histones and non-histone proteins including transcription factors, which subsequently ...
Xiyao Shi +13 more
doaj +1 more source
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation [PDF]
Science, 2020 Ömer Gilan +2 more
exaly +2 more sources
Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins by JQ1 Unravels a Novel Epigenetic Modulation to Control Lipid Homeostasis [PDF]
International Journal of Molecular Sciences, 2020 Claudia Tonini +2 more
exaly +2 more sources
Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia
OncoImmunology, 2021 B7-H6, a ligand for the NK activating receptor NKp30, has been identified as a biomarker of poor prognosis in several solid cancers. However, little is known about the role of B7-H6 and the mechanisms that control its expression in acute myeloid leukemia
Aroa Baragaño Raneros +7 more
doaj +1 more source
BET Protein-Mediated Transcriptional Regulation in Heart Failure [PDF]
International Journal of Molecular Sciences, 2021 Heart failure is a complex disease process with underlying aberrations in neurohormonal systems that promote dysregulated cellular signaling and gene transcription. Over the past 10 years, the advent of small-molecule inhibitors that target transcriptional machinery has demonstrated the importance of the bromodomain and extraterminal (BET) family of ...
Talha Ijaz, Michael A. Burke
openaire +2 more sources
Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
Pharmaceuticals, 2022 BET proteins, which recognize and bind to acetylated histones, play a key role in transcriptional regulation. The development of chemical BET inhibitors in 2010 greatly facilitated the study of these proteins.
Dayu Wu, Qiong Duan
doaj +1 more source
The role of BET attenuation in melanoma
, 2022 Bromodomain and extra-terminal (BETs) proteins function as epigenetic readers by docking onto acetylated lysine residues (Kac) on histone tails via tandem bromodomains (BRDs), and recruiting protein binding partners via an extra-terminal recruitment ...
Henderson, Elizabeth K
core +1 more source
Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators [PDF]
Cell Reports, 2019 Kareem N Mohni +2 more
exaly +2 more sources
BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes [PDF]
International Journal of Molecular Sciences, 2019 Peter J Thompson +2 more
exaly +2 more sources