BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
Molecules, 2023 The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer-related and immunity-associated genes.
Kenneth K. W. To +3 more
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BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. [PDF]
PLoS ONE, 2016 Displacement of Bromodomain and Extra-Terminal (BET) proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored.
Jude T Deeney +4 more
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Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis [PDF]
Bone, 2016 International audienceHistone modifications are important for maintaining the transcription program. BET proteins, an important class of " histone reading proteins " , have recently been described as essential in bone biology.
Berreur, M +28 more
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Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation [PDF]
Biomedicines, 2023 BET proteins function as histone code readers of acetylated lysins that determine the positive regulation in transcription of genes involved in cell cycle progression, differentiation, inflammation, and many other pathways. In recent years, thanks to the
Noemi Martella +8 more
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BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis
Scientific Reports, 2017 Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure.
Thomas C. Roberts +7 more
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Cell Reports, 2013 A hallmark of retroviral replication is integration of the viral genome into host cell DNA. This characteristic makes retrovirus-based vectors attractive delivery vehicles for gene therapy.
Jan De Rijck +11 more
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Regulation of Cell Plasticity by Bromodomain and Extraterminal Domain (BET) Proteins: A New Perspective in Glioblastoma Therapy [PDF]
International Journal of Molecular Sciences, 2023 Marco Segatto +2 more
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Altered regulation and expression of genes by BET family of proteins in COPD patients.
PLoS ONE, 2017 BackgroundBET proteins (BRD2, BRD3, BRDT and BRD4) belong to the family of bromodomain containing proteins, which form a class of transcriptional co-regulators.
Rajneesh Malhotra +14 more
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Therapeutic Targeting of BET Proteins in Osteosarcoma
IUIOsteosarcoma (OS) is an aggressive bone cancer in pediatric, adolescent, and young adult patients with an exceedingly poor prognosis. An area of therapeutic opportunity is that OS exhibits increased oncogenic replication stress (RS), augmenting genome
Riyahi, Niknam
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Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system [PDF]
Journal of Biological Chemistry, 2020 Michael T Werner +2 more
exaly +2 more sources