Relevance of BET Family Proteins in SARS-CoV-2 Infection [PDF]
Biomolecules, 2021 The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date.
Nieves Lara-Ureña +1 more
doaj +5 more sources
Editorial: BET proteins in chromatin architecture, transcription and disease [PDF]
Frontiers in Molecular Biosciences, 2022 Amit Kumar Singh +5 more
doaj +4 more sources
BET Proteins as Attractive Targets for Cancer Therapeutics. [PDF]
Int J Mol Sci, 2021 Transcriptional dysregulation is a hallmark of cancer and can be an essential driver of cancer initiation and progression. Loss of transcriptional control can cause cancer cells to become dependent on certain regulators of gene expression.
Sarnik J, Popławski T, Tokarz P.
europepmc +5 more sources
Therapeutic Targeting of BET Proteins in Sarcoma. [PDF]
Mol Cancer TherBromodomain and extraterminal (BET) domain protein family are epigenetic readers that regulate gene transcription, cell-cycle progression, and DNA damage response (DDR), making them attractive therapeutic targets for sarcomas, which are epigenetically ...
Riyahi N +8 more
europepmc +4 more sources
BET Proteins as Targets for Anticancer Treatment
Cancer Discovery, 2018 Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate gene expression and are involved in cancer pathogenesis. Over the last years, several BET inhibitors have been developed and clinically tested.
Francesco Bertoni, Anastasios Stathis
core +4 more sources
BET proteins are a key component of immunoglobulin gene expression [PDF]
Epigenomics, 2017 Aims: Bromo and extraterminal domain (BET) proteins have been shown to regulate gene expression including inflammatory genes. Methods: In order to investigate the role of the BET proteins in immunoglobulin production we treated the human B cell line ...
Russell, Kirsty E. +23 more
core +5 more sources
PCNA Unloading Is Negatively Regulated by BET Proteins
Cell Reports, 2019 Summary: Proliferating cell nuclear antigen (PCNA) is a DNA clamp essential for DNA replication. During DNA synthesis, PCNA is continuously loaded onto and unloaded from DNA.
Mi-Sun Kang +10 more
doaj +4 more sources
BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos [PDF]
BMC Biology, 2022 Background During mammalian preimplantation development, as the fertilized egg develops and differentiates, three cell lineages become specified: trophectoderm (TE), epiblast, and primitive endoderm (PrE).
Mami Tsume-Kajioka +4 more
doaj +2 more sources
Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins [PDF]
Molecular Therapy: Nucleic Acids, 2023 Targeting aberrant epigenetic programs that drive tumorigenesis is a promising approach to cancer therapy. DNA-encoded library (DEL) screening is a core platform technology increasingly used to identify drugs that bind to protein targets.
Seoyeon Jeong +5 more
doaj +2 more sources
BET bromodomain proteins are required for glioblastoma cell proliferation [PDF]
Epigenetics, 2014 Epigenetic proteins have recently emerged as novel anticancer targets. Among these, bromodomain and extra terminal domain (BET) proteins recognize lysine-acetylated histones, thereby regulating gene expression.
Volmar, Claude-Henry +11 more
core +3 more sources