Results 11 to 20 of about 1,696,062 (260)
Dysregulation of BET proteins in levodopa-induced dyskinesia [PDF]
Neurobiology of Disease, 2017 Levodopa (L-DOPA) remains the most effective pharmacological treatment for Parkinson Disease (PD) but its use is limited by the development of debilitating drug-related side effects, particularly L-DOPA induced dyskinesia (LID).
David A. Figge, David G. Standaert
doaj +5 more sources
Editorial: BET proteins in chromatin architecture, transcription and disease [PDF]
Frontiers in Molecular Biosciences, 2022 Amit Kumar Singh +5 more
doaj +4 more sources
BET Proteins as Targets for Anticancer Treatment
Cancer Discovery, 2018 Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate gene expression and are involved in cancer pathogenesis. Over the last years, several BET inhibitors have been developed and clinically tested.
Francesco Bertoni, Anastasios Stathis
core +4 more sources
Relevance of BET Family Proteins in SARS-CoV-2 Infection
Biomolecules, 2021 The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date.
Nieves Lara-Ureña +1 more
doaj +2 more sources
Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins [PDF]
Molecular Therapy: Nucleic Acids, 2023 Targeting aberrant epigenetic programs that drive tumorigenesis is a promising approach to cancer therapy. DNA-encoded library (DEL) screening is a core platform technology increasingly used to identify drugs that bind to protein targets.
Seoyeon Jeong +5 more
doaj +2 more sources
PCNA Unloading Is Negatively Regulated by BET Proteins
Cell Reports, 2019 Summary: Proliferating cell nuclear antigen (PCNA) is a DNA clamp essential for DNA replication. During DNA synthesis, PCNA is continuously loaded onto and unloaded from DNA.
Mi-Sun Kang +10 more
doaj +4 more sources
BET proteins are a key component of immunoglobulin gene expression [PDF]
Epigenomics, 2017 Aims: Bromo and extraterminal domain (BET) proteins have been shown to regulate gene expression including inflammatory genes. Methods: In order to investigate the role of the BET proteins in immunoglobulin production we treated the human B cell line ...
Russell, Kirsty E. +23 more
core +5 more sources
BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis [PDF]
Scientific Reports, 2017 Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure.
Thomas C. Roberts +7 more
doaj +2 more sources
Regulation of Cell Plasticity by Bromodomain and Extraterminal Domain (BET) Proteins: A New Perspective in Glioblastoma Therapy [PDF]
International Journal of Molecular Sciences, 2023 Sabrina Di Bartolomeo, Marco Segatto
exaly +2 more sources
, 2019 9th Bet Debora Conference "Jewish Women: Being Present, Bringing Change" covered following topics: contemporary women’s perspectives on Jewish tradition; advocacy for other minority groups: activism against antisemitism, antiziganism, racism, and ...
core +7 more sources