Results 41 to 50 of about 43,525 (155)
Frontiers in Molecular Biosciences, 2020 Bromodomain and extra-terminal domain (BET) family proteins have become a hot research area because of their close relationship with a variety of human diseases.
Ping Bai +9 more
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BET Proteins: An Approach to Future Therapies in Transplantation [PDF]
American Journal of Transplantation, 2017 In order to develop new efficient therapies for organ transplantation, it is essential to acquire a comprehensive knowledge of the molecular mechanisms and processes, such as immune activation, chronic inflammation, and fibrosis, which lead to rejection and long-term graft loss.
B, Suarez-Alvarez +3 more
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Functions of BET proteins in erythroid gene expression [PDF]
Blood, 2015 Key Points BETs promote GATA1 chromatin occupancy and subsequently activate transcription; they are generally not required for repression. BRD2 and BRD4 are essential for full GATA1 activity whereas BRD3 function overlaps with BRD2.
Aaron J, Stonestrom +10 more
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BET Bromodomain Proteins as Cancer Therapeutic Targets [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2016 Epigenetic regulators are emerging therapeutic targets in a wide variety of human cancers. BET bromodomain proteins have been identified as key regulators of oncogenic transcription factors including MYC; therefore, their inhibition might provide a way to block these "undruggable" targets.
Shaokun, Shu, Kornelia, Polyak
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Epigenetics in Oncohematology: Brief Review
Клиническая онкогематология, 2015 Objective. To discuss historical aspects of epigenetics as an independent branch of biology, as well as to describe post-translational modifications of DNA and histones (PTMs) as epigenetic events. Methods.
Anton Dmitrievich Shirin +2 more
doaj +1 more source
Targeting BET bromodomain proteins in solid tumors [PDF]
, 2017 There is increasing interest in inhibitors targeting BET (bromodomain and extra-terminal) proteins because of the association between this family of proteins and cancer progression.
Collier, Katharine A. +4 more
core +1 more source
BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice [PDF]
Nature Neuroscience, 2015 Precise regulation of transcription is crucial for the cellular mechanisms underlying memory formation. However, the link between neuronal stimulation and the proteins that directly interact with histone modifications to activate transcription in neurons remains unclear. Brd4 is a member of the bromodomain and extra-terminal domain (BET) protein family,
Erica Korb +4 more
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BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs [PDF]
Circulation Research, 2020 Epigenetic mechanisms involve the placing (writing) or removal (erasing) of histone modifications that allow heterochromatin to transition to the open, activated euchromatin state necessary for transcription. A third, less studied epigenetic pathway involves the reading of these specific histone marks once placed.
Patricia Cristine Borck +2 more
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Targeting BET bromodomain proteins in solid tumors
Oncotarget, 2016 There is increasing interest in inhibitors targeting BET (bromodomain and extra-terminal) proteins because of the association between this family of proteins and cancer progression. BET inhibitors were initially shown to have efficacy in hematologic malignancies; however, a number of studies have now shown that BET inhibitors can also block progression
Sahai, Vaibhav +4 more
openaire +5 more sources
BET proteins: Investigating BRDT as a potential target for male contraception. [PDF]
Bioorg Med Chem Lett, 2020 While many contraception options are available for women, birth control methods for men are limited to condoms and vasectomy. Past research into male contraceptives has focused on hormonal options but the associated side effects have thus far precluded this method from reaching the market.
Wisniewski A, Georg GI.
europepmc +4 more sources