Results 41 to 50 of about 1,696,062 (260)

Targeting BET bromodomain proteins in solid tumors [PDF]

, 2017
There is increasing interest in inhibitors targeting BET (bromodomain and extra-terminal) proteins because of the association between this family of proteins and cancer progression.
Collier, Katharine A., Eckerdt, Frank D., Redig, Amanda J, Sahai, Vaibhav, Munshi, Hidayatullah G.   +4 more
core   +1 more source

Targeting BET bromodomain proteins in solid tumors

Oncotarget, 2016
There is increasing interest in inhibitors targeting BET (bromodomain and extra-terminal) proteins because of the association between this family of proteins and cancer progression. BET inhibitors were initially shown to have efficacy in hematologic malignancies; however, a number of studies have now shown that BET inhibitors can also block progression
Sahai, Vaibhav, Collier, Katharine A., Eckerdt, Frank D., Munshi, Hidayatullah G., Redig, Amanda J   +4 more
openaire   +5 more sources

BET Bromodomain Proteins as Cancer Therapeutic Targets [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2016
Epigenetic regulators are emerging therapeutic targets in a wide variety of human cancers. BET bromodomain proteins have been identified as key regulators of oncogenic transcription factors including MYC; therefore, their inhibition might provide a way to block these "undruggable" targets.
Shaokun, Shu, Kornelia, Polyak
openaire   +2 more sources

BETTING ON ALTERNATIVES: TARGETING TELOMERIC DILNCRNA AND BET PROTEINS IN ALT CANCER

, 2023
The Alternative Lengthening of Telomeres (ALT) pathway is a homology-driven, damage-induced mechanism of telomere maintenance (TMM) that sustains the proliferation of 10-15% of human cancers. We have recently discovered that damaged DNA, including deprotected telomeres, triggers de novo transcription of damage-induced long non-coding RNA (dilncRNA ...
openaire   +1 more source

BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice [PDF]

Nature Neuroscience, 2015
Precise regulation of transcription is crucial for the cellular mechanisms underlying memory formation. However, the link between neuronal stimulation and the proteins that directly interact with histone modifications to activate transcription in neurons remains unclear. Brd4 is a member of the bromodomain and extra-terminal domain (BET) protein family,
Erica Korb, Margo Herre, Ilana Zucker-Scharff, Robert B Darnell, C David Allis   +4 more
openaire   +2 more sources

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

Epigenetics & Chromatin, 2019
Background Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding
P. Khoueiry, A. Ward Gahlawat, M. Petretich, A. M. Michon, D. Simola, E. Lam, E. E. Furlong, V. Benes, M. A. Dawson, R. K. Prinjha, G. Drewes, P. Grandi   +11 more
doaj   +1 more source

The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type

Exploration of Targeted Anti-tumor Therapy, 2021
Aim: Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that play a fundamental role in transcription regulation. Preclinical and early clinical evidence sustain BET targeting as an anti-cancer approach.
Chiara Tarantelli, Eleonora Cannas, Hillarie Ekeh, Carmelo Moscatello, Eugenio Gaudio, Luciano Cascione, Sara Napoli, Cesare Rech, Andrea Testa, Chiara Maniaci, Andrea Rinaldi, Emanuele Zucca, Anastasios Stathis, Alessio Ciulli, Francesco Bertoni   +14 more
doaj   +1 more source

Stability of the Bet v 1 cross-reactive allergens Api g 1 and Dau c 1 : a biophysical approach [PDF]

, 2009
The allergen Bet v 1 is known as the primary sensitizer for birch pollen-related food allergy and is responsible for IgE cross-reactivity to pathogenesis-related 10 (PR-10) proteins from, in particular, fruits from the Rosaceae and vegetables from the ...
Bollen, M.A.
core  

Functions, structure, and read-through alternative splicing of feline APOBEC3 genes [PDF]

, 2008
Background Over the past years a variety of host restriction genes have been identified in human and mammals that modulate retrovirus infectivity, replication, assembly, and/or cross-species transmission. Among these host-encoded restriction factors, the
Marion Battenberg, O'Brien, Stephen J., Hotz-Wagenblatt, Agnes, Battenberg, Marion, Thomas Beck, Sarah Chareza, O\u27Brien, Stephen J., Thielebein, Jens, Jörg Zielonka, Münk, Carsten, Cichutek, Klaus, Beck, Thomas W., Zielonka, Jörg, Chareza, Sarah, Bravo, Ignacio G., Beck, Thomas, Jens Thielebein, Klaus Cichutek, Ignacio G Bravo, Löchelt, Martin, Martin Löchelt, Carsten Münk, Agnes Hotz-Wagenblatt, Yuhki, Naoya, Stephen J O'Brien, Naoya Yuhki   +25 more
core   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source