Results 41 to 50 of about 157,278 (142)

Case Report: Optic neuritis as the initial presentation of Orientia tsutsugamushi infection detected by metagenomic next-generation sequencing

Frontiers in Immunology, 2023
Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi infection, and typically manifested as fever, eschar, lymphadenopathy, rash, and other flu-like signs.
Chuan-bin Sun, Zhiqiong Ma, Zhe Liu
doaj   +1 more source

Antiphospholipid Syndrome and Kidney Involvement: New Insights

Antibodies, 2016
Antiphospholipid syndrome is an autoimmune disorder characterized by vascular thromboses and pregnancy morbidity associated with antiphospholipid antibodies: lupus anticoagulant, IgG or IgM anticardiolipin or anti-beta 2-glycoprotein I. The kidney is one
José A. Martínez-Flores, Manuel Serrano, Jose M. Morales, Antonio Serrano   +3 more
doaj   +1 more source

Origin and pathogenesis of antiphospholipid antibodies

Brazilian Journal of Medical and Biological Research, 1998
Antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies that are detected in the serum of patients with a variety of conditions, including autoimmune (systemic lupus erythematosus), infectious (syphilis, AIDS) and lymphoproliferative ...
C.M. Celli, A.E. Gharavi
doaj   +1 more source

Investigating the Antiviral Properties of Nyctanthes arbor-tristis Linn against the Ebola, SARS-CoV-2, Nipah, and Chikungunya Viruses: A Computational Simulation Study

Pharmaceuticals
Background: The hunt for naturally occurring antiviral compounds to combat viral infection was expedited when COVID-19 and Ebola spread rapidly. Phytochemicals from Nyctanthes arbor-tristis Linn were evaluated as significant inhibitors of these viruses ...
Raed Albiheyri, Varish Ahmad, Mohammad Imran Khan, Faisal A. Alzahrani, Qazi Mohammad Sajid Jamal   +4 more
doaj   +1 more source

3005 Integrin Mac-1 Potentiates Neutrophil Adhesion and NET Release in Antiphospholipid Syndrome

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: While the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of leukocytes has received considerably less attention.
Gautam Sule, William J. Kelley, Srilakshmi Yalavarthi, Omolola Eniola-Adefeso, Jason S. Knight   +4 more
doaj   +1 more source

Clinical and laboratory characteristics of Brazilian versus non-Brazilian primary antiphospholipid syndrome patients in AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) clinical database and repository

Advances in Rheumatology, 2021
Background Antiphospholipid syndrome (APS) is characterized by episodes of thrombosis, obstetric morbidity or both, associated with persistently positive antiphospholipid antibodies (aPL).
Erivelton de Azevedo Lopes, Gustavo Guimarães Moreira Balbi, Maria G. Tektonidou, Vittorio Pengo, Savino Sciascia, Amaia Ugarte, H. Michael Belmont, Maria Gerosa, Paul R. Fortin, Chary Lopez-Pedrera, Lanlan Ji, Hannah Cohen, Guilherme Ramires de Jesús, D. Ware Branch, Cecilia Nalli, Michelle Petri, Esther Rodriguez, Nina Kello, Roberto Ríos-Garcés, Jason S. Knight, Tatsuya Atsumi, Rohan Willis, Maria Laura Bertolaccini, Doruk Erkan, Danieli Andrade, APS ACTION   +25 more
doaj   +1 more source

Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids [PDF]

Biochemical Journal, 1999
Considerable interest is currently focused on the interactions of beta-2 glycoprotein I (β2GPI) and anti-phospholipid antibodies with anionic phospholipids in an attempt to understand the association between these antibodies and clinical diseases such as thrombosis.
T A, Brighton, Y P, Dai, P J, Hogg, C N, Chesterman   +3 more
openaire   +2 more sources

Polimorfismo Val247Leu do gene β2-glicoproteína 1 pode justificar a gênese de anticorpos antiβ2GP1 e síndrome do anticorpo antifosfolípide na hanseníase multibacilar Val247Leu polymorphism of β2 glycoprotein 1 gene may justify the genesis of anti β2GP1 antibodies and Antiphospholipid Syndrome in Multibacillary Leprosy

Anais Brasileiros de Dermatologia, 2009
FUNDAMENTOS - Anticorpos antifosfolípides (AAF), como antiβ2GP1 (β2-glicoproteína 1), são descritos na hanseníase multibacilar (MB) sem, contudo, caracterizar a síndrome do anticorpo antifosfolípide (SAF), constituída por fenômenos ...
Maria José Franco Brochado, Margarida Maria Passeri do Nascimento, Paulo Louzada Junior, José Fernando C. Figueiredo, Ana Maria Roselino   +4 more
doaj   +1 more source

High Prevalence of aCL-IgA and aβ2GPI-IgA in Drug-Free Schizophrenia Patients: Evidence of a Potential Autoimmune Link

Antibodies
Background/Objectives: Schizophrenia (SZ) is a complex psychiatric disorder with increasing evidence pointing to an autoimmune component, including the presence of antiphospholipid antibodies (aPLs).
Samar Samoud, Imen Zamali, Fatma Korbi, Ahlem Mtiraoui, Ahlem Ben Hmid, Neila Hannachi, Yousr Galai, Hechmi Louzir, Yousri El Kissi   +8 more
doaj   +1 more source

The J-shape of β2GPI reveals a cryptic discontinuous epitope across domains I and II

Journal of Structural Biology: X
Beta-2-Glycoprotein I is the main target for pathogenic antiphospholipid syndrome autoantibodies. It can adopt several conformations, including an O-shape and two more linear J- and S-shapes.
C.J. Lalaurie, M. Kulke, N. Geist, M. Delcea, P.A. Dalby, T.C.R. McDonnell   +5 more
doaj   +1 more source