Results 231 to 240 of about 1,107,155 (284)
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Current progress in beta-amyloid immunotherapy
Current Opinion in Immunology, 2004As neuroscientists, we are taught that the brain is immune privileged and thus unlikely to be affected by the peripheral immune system. Accordingly, initial results demonstrating the effectiveness of beta-amyloid (Abeta) immunotherapy in mouse models of Alzheimer's disease (AD) were viewed with considerable surprise and some skepticism.
Dale, Schenk +2 more
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Brain : a journal of neurology, 2003
The accumulation of beta-amyloid (A beta) in neuritic plaques is thought to be causative for the progression of Alzheimer's disease (AD). Recently, both active immunization and passive administration of A beta antibodies dramatically attenuated amyloid plaque deposition, neuritic dystrophy, astrogliosis and behaviour deficits in transgenic animals.
Yansheng, Du +9 more
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The accumulation of beta-amyloid (A beta) in neuritic plaques is thought to be causative for the progression of Alzheimer's disease (AD). Recently, both active immunization and passive administration of A beta antibodies dramatically attenuated amyloid plaque deposition, neuritic dystrophy, astrogliosis and behaviour deficits in transgenic animals.
Yansheng, Du +9 more
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Down syndrome and beta-amyloid deposition
Current Opinion in Neurology, 2004Exciting new therapeutic approaches to the treatment or prevention of Alzheimer's disease involve preventing, slowing or reversing beta-amyloid accumulation. These interventions may also apply to the treatment of Alzheimer's disease in Down syndrome.
Elizabeth, Head, Ira T, Lott
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The role of beta-amyloid in Alzheimer's disease
Medical Clinics of North America, 2002The current understanding of the role of amyloid in AD has been established by a remarkable congruence of multiple disciplines: neuropathology, biochemistry, molecular biology, and epidemiologic genetics. Although the precise etiology of AD still remains poorly understood, the identification of the key biochemical players in the A beta generation (APP,
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The Role of Iron in Beta Amyloid Toxicity
Biochemical and Biophysical Research Communications, 1995There is evidence that oxidative damage plays a causative role in Alzheimer's disease and amyloid beta protein (A beta) toxicity. Iron is frequently a potent facilitator of free radical production due to its ability to mediate the conversion of H2O2 to hydroxyl radicals via the Fenton reaction or by virtue of hypervalent iron compounds.
D, Schubert, M, Chevion
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Peptide Inhibitors of Beta Amyloid Aggregation
Current Topics in Medicinal Chemistry, 2002Amyloid beta peptide (Abeta) is implicated in the pathogenesis of Alzheimer s disease (AD), particularly as oligomers or polymers that are correlated with Abeta cellular toxicity. Inhibition of the formation of toxic forms of Abeta has therefore emerged as one approach to the treatment of AD. This article reviews efforts to adapt the structure of Abeta
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2023
Alzheimer's is one of the central topics in medical research and is gaining importance. The main cause of the disease is beta-amyloid, a protein that also occurs physiologically in the brain. However, a disturbed degradation leads to the formation of aggregates, which subsequently interfere with the transmission of stimuli and thus trigger the disease.
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Alzheimer's is one of the central topics in medical research and is gaining importance. The main cause of the disease is beta-amyloid, a protein that also occurs physiologically in the brain. However, a disturbed degradation leads to the formation of aggregates, which subsequently interfere with the transmission of stimuli and thus trigger the disease.
openaire +1 more source
Functional neurology, 1993
beta-amyloid (beta A, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death.
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beta-amyloid (beta A, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death.
openaire +1 more source
Amyloid Beta in Aging and Alzheimer’s Disease
International Journal of Molecular Sciences, 2022Jonathan Kopel +2 more
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