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Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers
Biochemical and Biophysical Research Communications, 2011Aggregation of a peptide, beta-amyloid (Aβ), is a hallmark molecular process found in Alzheimer's disease (AD). During Aβ aggregation, oligomeric and fibrillar Aβ are formed, and these molecular self-assembly steps are implicated in generation of toxic effects in AD.
Joon Ho, Ahn +3 more
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Clearance of Beta-Amyloid in the Brain
Current Medicinal Chemistry, 2014Intravascular substances invade extracellular spaces in the brain via endothelial cells in the sites without bloodbrain barrier (BBB) and move not only in the cerebrospinal fluid (CSF) but also in the interstitial fluid (ISF) of brain parenchyma adjacent to non-BBB sites.
Masaki, Ueno +4 more
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Current progress in beta-amyloid immunotherapy
Current Opinion in Immunology, 2004As neuroscientists, we are taught that the brain is immune privileged and thus unlikely to be affected by the peripheral immune system. Accordingly, initial results demonstrating the effectiveness of beta-amyloid (Abeta) immunotherapy in mouse models of Alzheimer's disease (AD) were viewed with considerable surprise and some skepticism.
Dale, Schenk +2 more
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Beta-amyloid immunisation in Alzheimer’s disease
Neurological Sciences, 2005Beta-amyloid immunisation in Alzheimer's ...
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