Results 261 to 270 of about 896,426 (307)
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Down syndrome and beta-amyloid deposition
Current Opinion in Neurology, 2004Exciting new therapeutic approaches to the treatment or prevention of Alzheimer's disease involve preventing, slowing or reversing beta-amyloid accumulation. These interventions may also apply to the treatment of Alzheimer's disease in Down syndrome.
Elizabeth, Head, Ira T, Lott
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The Role of Iron in Beta Amyloid Toxicity
Biochemical and Biophysical Research Communications, 1995There is evidence that oxidative damage plays a causative role in Alzheimer's disease and amyloid beta protein (A beta) toxicity. Iron is frequently a potent facilitator of free radical production due to its ability to mediate the conversion of H2O2 to hydroxyl radicals via the Fenton reaction or by virtue of hypervalent iron compounds.
D, Schubert, M, Chevion
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Brain : a journal of neurology, 2003
The accumulation of beta-amyloid (A beta) in neuritic plaques is thought to be causative for the progression of Alzheimer's disease (AD). Recently, both active immunization and passive administration of A beta antibodies dramatically attenuated amyloid plaque deposition, neuritic dystrophy, astrogliosis and behaviour deficits in transgenic animals.
Yansheng, Du +9 more
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The accumulation of beta-amyloid (A beta) in neuritic plaques is thought to be causative for the progression of Alzheimer's disease (AD). Recently, both active immunization and passive administration of A beta antibodies dramatically attenuated amyloid plaque deposition, neuritic dystrophy, astrogliosis and behaviour deficits in transgenic animals.
Yansheng, Du +9 more
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The role of beta-amyloid in Alzheimer's disease
Medical Clinics of North America, 2002The current understanding of the role of amyloid in AD has been established by a remarkable congruence of multiple disciplines: neuropathology, biochemistry, molecular biology, and epidemiologic genetics. Although the precise etiology of AD still remains poorly understood, the identification of the key biochemical players in the A beta generation (APP,
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Peptide Inhibitors of Beta Amyloid Aggregation
Current Topics in Medicinal Chemistry, 2002Amyloid beta peptide (Abeta) is implicated in the pathogenesis of Alzheimer s disease (AD), particularly as oligomers or polymers that are correlated with Abeta cellular toxicity. Inhibition of the formation of toxic forms of Abeta has therefore emerged as one approach to the treatment of AD. This article reviews efforts to adapt the structure of Abeta
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Synthesis and fluorescent labeling of beta‐amyloid peptides
Journal of Peptide Science, 2001AbstractFluorescent cell analytical techniques require the incorporation of a fluorophore into the target molecule without causing a significant change in the native conformation. Many short peptides have a limited number of reactive groups that can be labeled without affecting the biological activity.
L, Fülöp, B, Penke, M, Zarándi
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2023
Alzheimer's is one of the central topics in medical research and is gaining importance. The main cause of the disease is beta-amyloid, a protein that also occurs physiologically in the brain. However, a disturbed degradation leads to the formation of aggregates, which subsequently interfere with the transmission of stimuli and thus trigger the disease.
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Alzheimer's is one of the central topics in medical research and is gaining importance. The main cause of the disease is beta-amyloid, a protein that also occurs physiologically in the brain. However, a disturbed degradation leads to the formation of aggregates, which subsequently interfere with the transmission of stimuli and thus trigger the disease.
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The role of protein phosphorylation in beta amyloid toxicity
Brain Research, 1997Recent evidence suggests that amyloid beta protein (A beta) mediates the neurotoxicity observed in Alzheimer's disease (AD). Little is known, however, about the cytotoxic pathway leading to nerve cell death. Using a rat brain cell line which is sensitive to A beta, it is shown that a 50-60 kDa protein becomes more phosphorylated when cells are exposed ...
S, Tan, P, Maher, D, Schubert
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Functional neurology, 1993
beta-amyloid (beta A, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death.
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beta-amyloid (beta A, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death.
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The American journal of pathology, 1992
The presence of extracellular deposits of beta-amyloid protein in the brain is a hallmark of Alzheimer's disease (AD). In an effort to determine the effect of amyloid in an animal model, the authors injected amyloid cores isolated from AD brains into the cortex and hippocampus of rats. Lipofuscin, a major contaminant of the plaque core preparation, was
S A, Frautschy, G M, Cole, A, Baird
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The presence of extracellular deposits of beta-amyloid protein in the brain is a hallmark of Alzheimer's disease (AD). In an effort to determine the effect of amyloid in an animal model, the authors injected amyloid cores isolated from AD brains into the cortex and hippocampus of rats. Lipofuscin, a major contaminant of the plaque core preparation, was
S A, Frautschy, G M, Cole, A, Baird
openaire +1 more source