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Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Raab MS, Breitkreutz I, Tonon G, et al. Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling. Blood. 2009;113(7):1513-1521.

Blood
europepmc   +1 more source

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Wnt/beta-Catenin Signaling in Glioma

Journal of NeuroImmune Pharmacology, 2012
Extensive data have shown that Wnt/beta-catenin signaling is associated with various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of Wnt/beta-catenin signaling in glioma, with particular focus on the expression signatures of the main components in Wnt/beta-catenin signaling, the role of key factors ...
Kailiang Zhang, Lei Han
exaly   +3 more sources

Adenoid ameloblastoma harbors beta-catenin mutations

Modern Pathology, 2022
Adenoid ameloblastoma is a very rare benign epithelial odontogenic tumor characterized microscopically by epithelium resembling conventional ameloblastoma, with additional duct-like structures, epithelial whorls, and cribriform architecture. Dentinoid deposits, clusters of clear cells, and ghost-cell keratinization may also be present.
Victor Coutinho Bastos, Bruna Pizziolo Coura, Letícia Martins Guimarães, Bianca Gomes Fernandes, Alexander Chak-Lam Chan, Pablo Agustin Vargas, Luciana Bastos-Rodrigues, Luiz Armando De Marco, John Hellstein, Selvam Thavaraj, John M. Wright, Edward William Odell, Ricardo Santiago Gomez, Carolina Cavaliéri Gomes   +13 more
openaire   +3 more sources

MicroRNA roles in beta-catenin pathway [PDF]

Molecular Cancer, 2010
Abstractβ-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis.
Lei Han, Chun-sheng Kang
exaly   +4 more sources

beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles

British Journal of Dermatology, 2001
beta-catenin functions in signal transduction in the Wnt signalling pathway, which has recently been implicated in hair follicle (HF) morphogenesis. beta-catenin gene mutations affecting exon 3 have been reported in a high percentage of human pilomatrixomas.
G, Moreno-Bueno, C, Gamallo, L, Pérez-Gallego, F, Contreras, J, Palacios   +4 more
openaire   +2 more sources

p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction

European Journal of Neuroscience, 2001
The neuronal cyclin-dependent kinase p35/cdk5 comprises a catalytic subunit (cdk5) and an activator subunit (p35). To identify novel p35/cdk5 substrates, we utilized the yeast two-hybrid system to screen for human p35 binding partners. From one such screen, we identified beta-catenin as an interacting protein.
Kesavapany, S, Lau, K F, McLoughlin, D M, Brownlees, J, Ackerley, S, Leigh, P N, Shaw, C E, Miller, C C J   +7 more
openaire   +3 more sources