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Beta‐catenin and axis formation in planarians
BioEssays, 2009AbstractIn three recent articles it was shown that β‐catenin is crucial for the establishment and the maintenance of the overall polarity and especially for the character ‘posterior’ in planarians. If the transcription of the β‐catenin gene was silenced by RNA interference, the overall polarity is lost, and in regenerating fragments a posterior ...
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Beta-Catenin and the Survival of Hepatocytes
2017The Wnt/β-catenin pathway is critical for liver development, differentiation, metabolism, and homeostasis. Aberrations in this pathway have also been identified in many pathophysiological conditions, such as nonalcoholic steatohepatitis, fibrosis, and hepatobiliary neoplasias.
Kari Nichole Nejak-Bowen +1 more
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IKK and (Beta)-Catenin in Breast Cancer
2002Abstract : The wnt signaling pathway activates oncogene, beta-catenin. It associates with an APC, GSK-3b and axin complex which targets it for phosphorylation and ubiquitin-mediated degradation. NFkB transcription factor is associated with inhibitory IkBa.
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Cancer research, 2002
beta-Catenin and its close homologue plakoglobin (gamma-catenin) are major constituents of submembranal cell-cell adhesion sites. In addition, beta-catenin is a key component in the canonical Wnt pathway. Aberrantly activated beta-catenin signaling contributes to cancer progression by inducing [in complex with lymphocyte enhancer factor (LEF)/T-cell ...
Michael, Shtutman +4 more
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beta-Catenin and its close homologue plakoglobin (gamma-catenin) are major constituents of submembranal cell-cell adhesion sites. In addition, beta-catenin is a key component in the canonical Wnt pathway. Aberrantly activated beta-catenin signaling contributes to cancer progression by inducing [in complex with lymphocyte enhancer factor (LEF)/T-cell ...
Michael, Shtutman +4 more
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HIF-2alpha enhances beta-catenin/TCF-driven transcription by interacting with beta-catenin.
Cancer research, 2011The tumor-promoting factors β-catenin and hypoxia-inducible factor (HIF) are often found to be coactivated in rapidly growing tumors. Recently, it was shown that HIF-1α negatively regulates Wnt/β-catenin signaling by sequestering β-catenin from β-catenin/T-cell factor (TCF).
Hyunsung, Choi +3 more
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P53 and Beta-Catenin in Colorectal Cancer Progression
Current Pharmaceutical Design, 2003Recently a possible cross talk about the relationship between p53 and beta-catenin has been suggested by the observation that colorectal cancers accumulating beta-catenin (as a result of APC mutations) also exhibit high frequency p53 mutations. Our aim was to evaluate the pattern of both the proteins and match these with the morphological changes in ...
Anna Maria, Valentini +4 more
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Beta-catenin is not activated by downregulation of PTEN in osteoblasts
In Vitro Cellular & Developmental Biology - Animal, 2009Selective knockdown of phosphatase and tensin homolog (PTEN) has been recently shown to increase life long accumulation of bone and its ability to increase osteoblast lifespan. In order to determine how loss of PTEN function affects osteoblast differentiation, we created cell lines with stable knockdown of PTEN expression using short hairpin RNA ...
Emily, Hays +2 more
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beta-catenin-cell adhesion and beyond (review)
International Journal of Oncology, 1997beta-catenin was originally identified as a cytosolic cell protein required for the correct function of the cadherin cell-cell adhesion complex. However, recent studies have identified the presence of intracellular pools of beta-catenin that are cadherin-independent and that beta-catenin is also involved in Wnt-1, src and Tcf-Lef mediated intracellular
W, Jiang, S, Hiscox
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Proteininteraktionspartner von beta-Catenin
2004Titelblatt 1 Einleitung 1.1 PDZ-Proteine und Signaltransduktion 1.2 Der Wnt-Signaltransduktionsweg 1.3 Bcr: negativer Regulator der pathogenen Effekte von Bcr-Abl 2 Leitfaden dieser Arbeit 3 Material und Methoden 3.1 Material 3.2 Methoden 4 Ergebnisse 4.1 Identifikation von PDZ-abhängigen Proteininteraktionen 4.2 PDZ-Protein Erbin, Interaktionspartner ...
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Signal transduction of beta-catenin.
Current opinion in cell biology, 1996Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. Its signaling activity is distinct from its role in cadherin-mediated cell adhesion, and it probably acts either in the cytosol or in the nucleus.
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