Results 251 to 260 of about 119,479 (336)

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

open access: yesCytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda   +4 more
wiley   +1 more source

Immunoexpression of Ki67, P16 and Beta-catenin in precursor lesions of cutaneous squamous cell carcinoma. [PDF]

open access: yesRom J Morphol Embryol
Vîlcea AM   +6 more
europepmc   +1 more source

WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene.

open access: gold, 2000
Lifeng Xu   +4 more
openalex  

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

open access: yesChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi   +9 more
wiley   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

open access: yesChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti   +4 more
wiley   +1 more source

beta-catenin independent WNT signaling

open access: yesReactome - a curated knowledgebase of biological pathways, 2014
openaire   +2 more sources

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