Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]
, 2012 Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Capovilla, Simon +8 more
core +2 more sources
Wnt/beta-catenin pathway: modulating anticancer immune response
Journal of Hematology & Oncology, 2017 Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal.
S. Pai +8 more
semanticscholar +1 more source
Kinetics of Wnt-driven beta-catenin stabilization revealed by quantitative and temporal imaging. [PDF]
PLoS ONE, 2008 The Wnt/beta-catenin signal transduction pathway regulates a broad range of developmental processes. Aberrant activation of the Wnt pathway leads to cancer and degenerative diseases.
Rami N Hannoush
doaj +1 more source
HGF/c-Met related activation of β-catenin in hepatoblastoma
Journal of Experimental & Clinical Cancer Research, 2011 Background Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin ...
Turner Clinton +6 more
doaj +1 more source
A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. [PDF]
PLoS ONE, 2009 The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is ...
Richard A Klinghoffer +10 more
doaj +1 more source
Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. [PDF]
, 2005 BackgroundDeregulation of the Wnt/ beta-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues. Mutations in components of this pathway result in beta-catenin stabilization and
Ashworth, Alan +2 more
core +3 more sources
Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling. [PDF]
, 2016 Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins ...
Kafka, Anja +2 more
core +2 more sources
Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]
, 2012 The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim +2 more
core +2 more sources
PPAR Research, 2017 In both colon cancer and type 2 diabetes, metabolic changes induced by upregulation of the Wnt/beta-catenin signaling and downregulation of peroxisome proliferator-activated receptor gamma (PPAR gamma) may help account for the frequent association of ...
Y. Lecarpentier +3 more
semanticscholar +1 more source
Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
core +1 more source