Results 41 to 50 of about 116,860 (335)
A comparison of the usefulness of nuclear beta‐catenin in the diagnosis of desmoid‐type fibromatosis among commonly used anti‐beta‐catenin antibodies [PDF]
, 2021 Desmoid-type fibromatosis (DF) is a locally aggressive but non-metastatic (myo)fibroblastic neoplasm. A hallmark of the tumor is nuclear positivity for beta-catenin in immunohistochemistry due mostly to CTNNB1 mutations.
Haga, Hironori +7 more
core +1 more source
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2008 BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function.
Melanie Königshoff +6 more
doaj +1 more source
eLife, 2019 Beta-catenin (i.e., canonical Wnt) signaling controls CNS angiogenesis and the blood-brain and blood-retina barriers. To explore the role of the Discs large/membrane-associated guanylate kinase (Dlg/MAGUK) family of scaffolding proteins in beta-catenin ...
Chris Cho +4 more
doaj +1 more source
Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. [PDF]
, 2016 Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Benham-Pyle, Blair W +4 more
core +2 more sources
Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells. [PDF]
, 2017 β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic
Bhattacharyya, A +7 more
core +1 more source
Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. [PDF]
PLoS ONE, 2009 Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber ...
Jin-Ming Tee +3 more
doaj +1 more source
Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling. [PDF]
, 2016 Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins ...
Kafka, Anja +2 more
core +2 more sources
Diagnostic Pathology, 2011 Background Beta-catenin, a component of the Wingless/Wnt signaling pathway, can activate target genes linking with the adenomatous polyposis coli (APC) gene in colorectal cancer.
Cheng Hongxia +3 more
doaj +1 more source
Genes and Diseases, 2016 Beta catenin has been well documented in previous studies to be involved in non small cell lung cancer (NSCLC). Beta catenin abundance and transcriptional activity are significantly regulated by several factors.
Supratim Ghatak, Sanghamitra Raha
doaj +1 more source
The Showa University Journal of Medical Sciences, 2006 Masaaki Sakamoto +9 more
openalex +4 more sources