Results 41 to 50 of about 1,106,914 (319)

Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer

open access: yesBMC Cancer, 2016
Helicobacter pylori is an important pathogenic factor in gastric carcinogenesis. Angiogenesis (i.e., the growth of new blood vessels) is closely associated with the incidence and development of gastric cancer.
Ningning Liu   +6 more
semanticscholar   +1 more source

Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor) [PDF]

open access: yesOncogene, 1999
Aggressive fibromatosis (also called desmoid tumor) occurs as a sporadic lesion or as part of Familial Adenomatous Polyposis, which is caused by germ line mutations in the Adenomatous polyposis Coli (APC) gene. APC is involved in the regulation of the cellular level of beta-catenin, which is a mediator in Wnt signaling.
S, Tejpar   +10 more
openaire   +2 more sources

Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma

open access: yesFrontiers in Neuroscience, 2016
The molecular mechanisms underlying the pathophysiology of Alzheimer's disease (AD) are still not fully understood. In AD, Wnt/beta-catenin signaling has been shown to be downregulated while the peroxisome proliferator-activated receptor (PPAR) gamma ...
Alexandre Vallée, Y. Lecarpentier
semanticscholar   +1 more source

Nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer

open access: yesDiagnostic Pathology, 2011
Background Beta-catenin, a component of the Wingless/Wnt signaling pathway, can activate target genes linking with the adenomatous polyposis coli (APC) gene in colorectal cancer.
Cheng Hongxia   +3 more
doaj   +1 more source

Differential alterations of positive and negative regulators of beta catenin enhance endogenous expression and activity of beta catenin in A549 non small cell lung cancer (NSCLC) cells

open access: yesGenes and Diseases, 2016
Beta catenin has been well documented in previous studies to be involved in non small cell lung cancer (NSCLC). Beta catenin abundance and transcriptional activity are significantly regulated by several factors.
Supratim Ghatak, Sanghamitra Raha
doaj   +1 more source

NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. [PDF]

open access: yesPLoS ONE, 2009
The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin.
Ali M Riazi   +7 more
doaj   +1 more source

Opposite Interplay between PPAR Gamma and Canonical Wnt/Beta-Catenin Pathway in Amyotrophic Lateral Sclerosis

open access: yesFrontiers in Neurology, 2016
The opposite interplay between peroxisome proliferator-activated receptor gamma (PPAR gamma) and Wnt/beta-catenin signaling has led to the categorization of neurodegenerative diseases (NDs) as either NDs in which PPAR gamma is downregulated while the ...
Y. Lecarpentier, Alexandre Vallée
semanticscholar   +1 more source

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

open access: yesGenes & Development, 1996
The serine/threonine kinase Xgsk-3 and the intracellular protein beta-catenin are necessary for the establishment of the dorsal-ventral axis in Xenopus.
C. Yost   +5 more
semanticscholar   +1 more source

Quercetin treatment reduces the severity of renal dysplasia in a beta-catenin dependent manner.

open access: yesPLoS ONE, 2020
Renal dysplasia, the major cause of childhood renal failure, is characterized by defective branching morphogenesis and nephrogenesis. Beta-catenin, a transcription factor and cell adhesion molecule, is markedly increased in the nucleus of kidney cells in
Joanna Cunanan   +7 more
doaj   +1 more source

Bioinformatics Knowledge Map for Analysis of Beta-Catenin Function in Cancer. [PDF]

open access: yesPLoS ONE, 2015
Given the wealth of bioinformatics resources and the growing complexity of biological information, it is valuable to integrate data from disparate sources to gain insight into the role of genes/proteins in health and disease.
İrem Çelen   +3 more
doaj   +1 more source

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