Results 131 to 140 of about 15,075 (247)

The fight of innate immunity and abnormal cannabinoids against Candida infection

British Journal of Pharmacology, EarlyView.
Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori, Ilan Zaffran, Francesca Levi Schaffer   +2 more
wiley   +1 more source

Cellular Proliferation and Reprogramming in Pre‐Metastatic Niches: Mechanisms and Therapeutic Vulnerabilities

Cell Proliferation, EarlyView.
This review systematically elucidates how primary tumours remotely drive multicellular reprogramming to construct the pre‐metastatic niche and dictate disseminated tumour cell fate. By mapping this dynamic ecosystem, we identify actionable therapeutic vulnerabilities, advocating a paradigm shift from traditional cytotoxicity toward microenvironment ...
Shengqian Wang, Chenghu Song, Pengfei Li, Junjie Feng, Xiaoxuan Shi, Qiwen Lu, Bohan Duan, Xinyan Zhang, Siqi Li, Yang Luo, Xiaohui Fan, Ziyun Li, Yang Zhang, Renjun Gu, Wenjun Mao   +14 more
wiley   +1 more source

Beta-Glucans Improve the Mammary Innate Immune Response to Endotoxin Challenge in Dairy Ewes. [PDF]

Animals (Basel)
Guamán SA, Elhadi A, Salama AAK, Manuelian CL, Caja G, Albanell E.   +5 more
europepmc   +1 more source

Functional and transcriptomic analyses in Neurospora crassa reveal a crucial role for the N‐glycoprotein deglycosylation process in fungal homeostasis

The FEBS Journal, EarlyView.
In Neurospora crassa, a cytosolic GH18 endo‐β‐n‐acetylglucosaminidase (ENGase) functions as an active deglycosylating enzyme. Deletion of this severely alters tolerance to multiple stress conditions and causes extensive transcriptomic reprogramming, including upregulation of a GH20 exo‐β‐n‐acetylhexosaminidase under ER stress, indicating that N. crassa
Anastasios Samaras, Tanim Jabid Hossain, Magnus Karlsson, Georgios Tzelepis   +3 more
wiley   +1 more source

Structural insights into xyloglucan recognition by an ABC transporter from a Gram‐positive, thermophilic bacterium

The FEBS Journal, EarlyView.
Athe_2052 is an ABC transporter substrate‐binding protein that recognizes xyloglucan heptasaccharide (XXXG), a soluble breakdown product of plant xyloglucan. The crystal structure of Athe_2052, together with binding assays and computational modeling, shows how XXXG is recognized by this sugar transporter.
Hansen Tjo, Virginia Jiang, Philip D. Jeffrey, Angela Zhu, A. James Link, Jerelle A. Joseph, Jonathan M. Conway   +6 more
wiley   +1 more source

Oat Beta-Glucans Modulate the Gut Microbiome, Barrier Function, and Immune Responses in an In Vivo Model of Early-Stage Colorectal Cancer. [PDF]

Int J Mol Sci
Guzowska M, Dziendzikowska K, Kopiasz Ł, Gajewska M, Wilczak J, Harasym J, Czerwińska M, Gromadzka-Ostrowska J.   +7 more
europepmc   +1 more source

The harnessing potential of carboxymethyl beta glucan: A driver of skin repair

International Journal of Cosmetic Science, EarlyView.
Carboxymethyl Beta‐Glucan (CM‐BG) drives skin repair through multifaceted actions, notably in wounded 3D models. It activates Dectin‐1 and mitigates inflammation (reducing pro‐inflammatory mediators, boosting anti‐inflammatory IL‐10) in cellular models, while enhancing epidermal differentiation and collagen I synthesis by fibroblasts across cellular ...
Caroline Pichon, Xavier Marat, Alice Brule, Annie Black, Audrey Gueniche   +4 more
wiley   +1 more source

Fluoride‐Free Mouthwashes Available Over‐The‐Counter in the US‐An Overview

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Purpose Fluoride‐free mouthwashes (FFM) are commonly used by patients for a variety of cosmetic and/or therapeutic reasons. The purpose of this study was to investigate the composition and purposes of FFM available over‐the‐counter in the US.
Astrid C. Valdivia‐Tapia, Jaime A. Cury, Antonio P. Ricomini‐Filho, Frank Lippert   +3 more
wiley   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Microbiota in Mild Inflammatory Bowel Disease (IBD) Can Be Modulated by Beta-Glucans and Mannanoligosaccharides: A Randomized, Double-Blinded Study in Dogs. [PDF]

Vet Sci
Amaral AR, Rentas MF, Rosa TCT, Pereira TAE, Marchi PH, Teixeira FA, Filho FOR, Putarov TC, Cogliati B, Vendramini THA, Balieiro JCC, Brunetto MA.   +11 more
europepmc   +1 more source