Results 51 to 60 of about 762,130 (279)

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

The Effect of Beta Glucan on Cisplatin Ototoxicity [PDF]

Indian Journal of Otolaryngology and Head & Neck Surgery, 2013
This study was undertaken to investigate the effect of betaglucan in ameliorating cisplatin ototoxicity. Rats were divided into four groups: cisplatin (C), cisplatin plus beta glucan (CB), beta glucan (B), and control (K). Distortion product otoacoustic emissions were elicited in 0th, 1st, and 5th days.
Tuba, Bayindir, Mustafa, Iraz, Mehmet, Kelles, Serdar, Kaya, Mehmet, Tan, Aliye, Filiz, Yuksel, Toplu, M Tayyar, Kalcioglu   +7 more
openaire   +2 more sources

Immune recognition. A new receptor for beta-glucans.

, 2001
The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them ...
Gordon, S, Brown, GD, Gordon, Siamon, Siamon Gordon, Gordon D. Brown   +4 more
core   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

INFLUENCE OF PLEUROTUS OSTREATUS β-GLUCANS ON THE GROWTH AND ACTIVITY OF CERTAIN LACTIC ACID BACTERIA

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2018
Over the last few decades, polysaccharides of fungi, namely beta-glucans captivated researchers' attention for they hold many significant properties; the most important ones are immunomodulating and antitumor properties. Although, beta-glucans are widely
M. S. KOKINA, M. FRIOUI, M. M. SHAMTSYAN, V. S. SIBIRTSEV, L. V. KRASNIKOVA, V. G. KONUSOVA, A. S. SIMBIRTSEV   +6 more
doaj  

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

The importance of beta-glucans in human nutrition.

, 2009
V bakalářské práci je zpracována problematika vlákniny a její konkrétní složky -beta-glukanů. Pojednáno je o charakteristice, zdrojích a fyziologických účincích jak beta-glukanů tak i vlákniny.
Janírková, Gabriela
core   +2 more sources

[beta]-Glucan Synthesis in the Cotton Fiber (II. Regulation and Kinetic Properties of [beta]-Glucan Synthases [PDF]

Plant Physiology, 1993
The regulation and kinetic properties of cellulose synthase as well as [beta]-1,3-glucan synthase have been studied. The cellulose was detected using acetic/nitric acid insolubility as an indicator of cellulose (this product contained only [beta]-1,4-linked glucans; K. Okuda, L. Li, K. Kudlicka, S. Kuga, R.M. Brown, Jr.
L., Li, R. M., Brown
openaire   +2 more sources