Results 81 to 90 of about 577 (171)

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

A novel glucose beta‐hydroxybutyrate combination improves hypoglycaemia recovery and patient‐reported outcomes in type 1 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Hypoglycaemia remains a major barrier to optimal diabetes management. Current treatments based on simple sugars have limitations, including rapid glucose fluctuations and persistent neuroglycopenic symptoms. We investigated FLO23011, a novel multi‐substrate energy formulation containing glucose and beta‐hydroxybutyrate, as a superior ...
D. Russell‐Jones, V. Smout, S. Roy, G. Myers, R. Littlewood, F. Shojaee‐Moradie   +5 more
wiley   +1 more source

Early versus late initiation of long‐acting insulin in paediatric and adult diabetic ketoacidosis: A systematic review and meta‐analysis of randomised control trials

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Diabetic ketoacidosis (DKA) is a serious complication of diabetes, requiring intravenous (IV) insulin until resolution and subsequent transition to subcutaneous insulin. Currently, clinical guidelines vary regarding the timing of long‐acting subcutaneous insulin initiation, with some advocating early administration during IV insulin ...
Bachviet Nguyen, Stephanie Quon, Balkaran Dhaliwal, Mark Warwas, Sara Stafford   +4 more
wiley   +1 more source

Performance of Holstein calves having free access to milk and dosed with Megasphaera elsdenii

Scientia Agricola
Megasphaera elsdenii converts lactate and glucose into butyrate, the main volatile fatty acid responsible of papillae development and may benefit calf performance.
Mukengela Claude Muya, Lourens Johannes Erasmus, Kevin Miller, Celine Aperce, Florence Veronica Nherera, Portia Mamothaladi Moshidi   +5 more
doaj   +1 more source

Acarbose or Canagliflozin vs. Placebo to Ameliorate Post‐Bariatric Hypoglycaemia: The Clinical Outcomes of the HypoBar I Randomised Clinical Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Treatment options for post‐bariatric hypoglycaemia (PBH) are empirical. We aimed to investigate the efficacy and safety of acarbose and canagliflozin for the treatment of PBH. Materials and Methods We performed a randomised, double‐blinded, cross‐over, placebo‐controlled clinical trial where placebo, acarbose 50 mg thrice daily, and ...
Carolina B. Lobato, Clara Tornøe Winding, Kirstine N. Bojsen‐Møller, Bolette Hartmann, Christoffer Martinussen, Simon Veedfald, Jens J. Holst, Sten Madsbad, Nils Bruun Jørgensen, Carsten Dirksen   +9 more
wiley   +1 more source

Intravenous Oxytocin Has no Effect on Ad Libitum Food Intake or Postprandial Plasma Glucose Concentrations in Individuals With Obesity: A Randomised, Placebo‐Controlled, Double‐Blind, Crossover Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Oxytocin is expressed throughout the small intestine, suggesting a role for oxytocin in postprandial metabolism. Accordingly, single‐dose intranasal oxytocin reduces food intake and improves glucose tolerance. We investigated the effects of a continuous intravenous oxytocin infusion on ad libitum food intake, appetite sensations ...
Ida M. Gether, Vivian Kliim‐Hansen, Petur T. Olafsson, Miriam G. Pedersen, Casper K. Nielsen, Anne‐Marie Ellegaard, Mikkel B. Christensen, Jens F. Rehfeld, Jørn W. Helge, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +13 more
wiley   +1 more source

Breakfast, plasma glucose and beta-hydroxybutyrate, body mass index and academic performance in children from Extremadura, Spain Desayuno, glucosa y beta-hidroxibutirato plasmaticos, índice de masa corporal y rendimiento académico en niños de Extremadura, España

Nutrición Hospitalaria, 2007
Objectives: Nutritional aspects of breakfast, plasma levels of glucose and beta-hydroxybutyrate, body mass index and academic performance have been studied in urban and rural children (Extremadura, Spain).
M.ª D. Torres, I. Carmona, C. Campillo, G. Pérez, J. E. Campillo   +4 more
doaj  

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Genetic Parameter Estimation for Plasma Biomarkers Associated With Energy Reserves During Critical Physiological Stages in Sheep

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The ability of ruminants to mobilise and restore body reserves (BR) over time, referred to as BR dynamics, is currently considered an interesting biological component to be included in breeding programs targeting enhanced BR resilience. However, genetic studies of proxies for BR levels and BRD remain scarce, particularly in small ruminants ...
Agnes Nyamiel, Andres Legarra, Didier Marcon, Christian Durand, Sébastien Douls, Gaetan Bonnafe, Anne Tesnière, Eliel González‐García, Dominique Hazard   +8 more
wiley   +1 more source