Results 41 to 50 of about 63,634 (227)

Utility of beta-lactam allergy assessment in patients receiving vancomycin for surgical prophylaxis

Surgery in Practice and Science
Background: Beta-lactam antibiotics are first-line agents for most patients receiving antimicrobial prophylaxis in surgical procedures. Despite evidence showing low cross-reactivity between penicillins and cephalosporins, patients with beta-lactam ...
Kendall J. Tucker, YoungYoon Ham, Haley K. Holmer, Caitlin M. McCracken, Ellie Sukerman, James S. Lewis, II, Jessina C. McGregor   +6 more
doaj   +1 more source

Procalcitonin predicts response to beta-lactam treatment in hospitalized children with community-acquired pneumonia. [PDF]

PLoS ONE, 2012
Antibiotic treatment of community-acquired pneumonia (CAP) in children remains mostly empirical because clinical and paraclinical findings poorly discriminate the principal causes of CAP.
Jérémie F Cohen, Alexander Leis, Thibault Lecarpentier, Josette Raymond, Dominique Gendrel, Martin Chalumeau   +5 more
doaj   +1 more source

Immobilization of IMP-1 metallo-beta-lactamase on Fe3O4@SiO2 as nanobiocatalyst for degradation of beta-lactam antibiotics in wastewater

Water Science and Technology, 2022
Residues of antibiotics in water resources and wastewater have been significant environmental and public health problems. The current study developed a high-efficiency enzymatic nanobiocatalyst for the degradation of beta-lactam antibiotics.
Mohammad javad Shokoohizadeh, Ali Almasi, Farahnaz Karami, Seyyed Alireza Mousavi, Reza Khodarahmi   +4 more
doaj   +1 more source

Chiral Potassium Brønsted Base‐Catalyzed Stereoselective Synthesis of 1,3‐Diols via a Tandem Allylic Isomerization/Asymmetric Aldol–Tishchenko Reaction

Advanced Synthesis &Catalysis, EarlyView.
Chiral potassium base catalysts featuring 1,1´‐bi‐2‐naphthol‐derived chiral crown ethers as ligands promote a tandem allylic isomerization/asymmetric aldol‐Tishchenko reaction of allylic alcohols and aldehydes. This method provides enantioenriched 1,3‐diols with excellent diastereoselectivity and high enantioselectivity, thereby expanding the synthetic
Hiroki Ishikawa, Masahiro Sai
wiley   +1 more source

Pyridine Into Pyrrole Transformation Induced Within the Confinement of the Macrocycle

Angewandte Chemie, EarlyView.
This work demonstrates the nontrivial reactivity of pyridine incorporated into a porphyrin framework. The most significant achievement is the contraction of the six‐membered ring to a pyrrole ring, which is a phenomenon of great interest to researchers in this field.
Paulina Krzyszowska, Agata Burska‐Jabłońska, Mateusz Oberski, Michał J. Białek, Lechosław Latos‐Grażyński, Karolina Hurej   +5 more
wiley   +2 more sources

Research Progress in Wearable Microneedle Sensors for Health Analysis

Advanced Sensor Research, EarlyView.
Wearable biosensors are transforming personal healthcare by enabling minimally invasive, molecular‐level monitoring. Emerging electrochemical microneedle sensors can detect analytes in interstitial fluid, enabling painless extraction and real‐time tracking.
Adnan Zameer, Yang Guo, Hongda Wang, Qiang Zhang   +3 more
wiley   +1 more source

Pharmacokinetic/Pharmacodynamic Target Attainment of Continuous Infusion Piperacillin–Tazobactam or Meropenem and Microbiological Outcome among Urologic Patients with Documented Gram-Negative Infections

Antibiotics, 2023
(1) Objectives: To describe the relationship between pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) piperacillin–tazobactam or meropenem monotherapy and microbiological outcome in a case series of urological ...
Pasquale Maria Berrino, Milo Gatti, Matteo Rinaldi, Eugenio Brunocilla, Pierluigi Viale, Federico Pea   +5 more
doaj   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Total Synthesis of (+)‐Melonine and (+)‐N4‐Oxy Melonine Enabled by an Intramolecular Alkene Diamination Reaction

Angewandte Chemie, EarlyView.
A complexity‐generating intramolecular alkene diamination constitutes the pivotal step in the enantioselective synthesis of the title natural products featuring a strained, cage‐like pentacyclic architecture. Abstract Among more than four thousand monoterpene indole alkaloids (MIAs) isolated to date, only a few feature a 2,2,3‐trisubstituted indoline ...
Vincent Goëlo, Qian Wang, Jieping Zhu
wiley   +2 more sources

Comparative in vitro activities of seven new beta-lactams, alone and in combination with beta-lactamase inhibitors, against clinical isolates resistant to third generation cephalosporins

Brazilian Journal of Infectious Diseases
We examined the drug susceptibility pattern of Gram-negative bacilli to seven new beta-lactams. A total of 277 non-duplicate gramnegative bacilli strains belonging to the Enterobacteriaceae family, Pseudomonas and Acinetobacter species, isolated from ...
Varsha Gupta, Priya Datta, Nalini Agnihotri, Jagdish Chander   +3 more
doaj   +1 more source