Results 51 to 60 of about 49,830 (257)

Identification of drivers of mycobacterial resistance to peptidoglycan synthesis inhibitors

Frontiers in Microbiology, 2022
Beta-lactams have been excluded from tuberculosis therapy due to the intrinsic resistance of Mycobacterium tuberculosis (Mtb) to this antibiotic class, usually attributed to a potent beta-lactamase, BlaC, and to an unusually complex cell wall.
Francisco Olivença, Cláudia Ferreira, Alexandra Nunes, Alexandra Nunes, Cátia Silveiro, Madalena Pimentel, João Paulo Gomes, João Paulo Gomes, Maria João Catalão   +8 more
doaj   +1 more source

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Modelling impacts of paediatric amoxicillin shortage management on pneumococcal resistance and invasive disease in Europe

Nature Communications
Antibiotic shortages are increasing worldwide. Their impact on individual health and bacterial ecology is unknown, but it could be significant, and there is a lack of epidemiological evidence. Here, we assess the impact of beta-lactam shortage management
Aurélie Maurin, Tristan Delory, Josselin Le Bel, Didier Guillemot, Mircea T. Sofonea, Laura Temime, Lulla Opatowski   +6 more
doaj   +1 more source

Is There Emergence of β-Lactam Antibiotic-Resistant Streptococcus pyogenes in China?

Infection and Drug Resistance, 2020
Dingle Yu,1,2,* Yuejie Zheng,2,* Yonghong Yang1,2 1Laboratory of Microbiology and Immunology, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China; 2Department of Respiratory, Shenzhen ...
Yu D, Zheng Y, Yang Y
doaj  

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Complete Nucleotide Sequence of Plasmids of Two Escherichia coli Strains Carrying blaNDM–5 and blaNDM–5 and blaOXA–181 From the Same Patient

Frontiers in Microbiology, 2020
Aim of this study was to genetically characterize two carbapenemase-producing Escherichia coli strains obtained from a pediatric patient affected by diarrhea, expressing OXA-181 and/or NDM-5 type enzymes.
Vittoria Mattioni Marchetti, Ibrahim Bitar, Ibrahim Bitar, Alessandra Mercato, Elisabetta Nucleo, Annalisa Bonomini, Palmino Pedroni, Jaroslav Hrabak, Jaroslav Hrabak, Roberta Migliavacca   +9 more
doaj   +1 more source

A Hunt for the Resistance of Haemophilus influnezae to Beta-Lactams

Antibiotics
Infections due to Haemophilus influnezae require prompt treatment using beta-lactam antibiotics. We used a collection of 81 isolates obtained between 1940 and 2001 from several countries. Whole genome sequencing showed the high heterogeneity of these isolates but allowed us to track the acquisition of beta-lactamase, which was first detected in 1980 ...
Denizon, Mélanie, Hong, Eva, Terrade, Aude, Taha, Muhamed-Kheir, Deghmane, Ala-Eddine   +4 more
openaire   +4 more sources

Conjugative transfer in the dissemination of beta-lactam and aminoglycoside resistance [PDF]

Frontiers in Bioscience, 1999
The dissemination of antibiotic resistance among pathogenic bacteria can be attributed largely to conjugative DNA transfer. The general category of conjugative transfer includes both bacterial plasmid conjugation and the transfer of nonreplicative conjugative transposons.
openaire   +2 more sources