Results 71 to 80 of about 2,940,166 (197)

Evolution of Broad Spectrum beta-Lactam Resistance in an Engineered Metallo-beta-lactamase

, 2013
The extensive use and misuse of antibiotics during the last seven decades has led to the evolution and global spread of a variety of resistance mechanisms in bacteria.
Sun, Song, Zhang, Wei, Sun, Song,, Andersson, Dan I.,, Zhang, Wei,, Andersson, Dan I., Mannervik, Bengt,   +6 more
core   +1 more source

Potential involvement of beta-lactamase homologous proteins in resistance to beta-lactam antibiotics in gram-negative bacteria of the ESKAPEE group

BMC Genomics
Background Enzymatic degradation mediated by beta-lactamases constitutes one of the primary mechanisms of resistance to beta-lactam antibiotics in gram-negative bacteria.
Joyce de Souza, Alexandre Zanatta Vieira, Hellen Geremias dos Santos, Helisson Faoro   +3 more
doaj   +1 more source

Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli

Molecules
Background: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat.
Youqi Ji, Yinhuan Wang, Zhangkai Xu, Danlei Chen, Zhendi Yu, Qingyi Shao, Xin Hong, Zishu Liu, Dongqing Cheng   +8 more
doaj   +1 more source

Extended spectrum Beta-Lactamase (ESBL) producing Enterobacterales: Classification and resistance genetic background [PDF]

Medicinski Podmladak, 2019
Beta-lactam antibiotics are one of the most important ones in clinical practice and most commonly prescribed drugs. There are few possible mechanisms of beta-lactam resistance.
Milić Marija, Mijač Vera
doaj  

Probing the Role of Asn 152 in the Class C β-lactamase AmpC [PDF]

, 2012
AmpC, a class C β-lactamase, is a main cause of antibiotic resistance to cephalosporins in many species of bacteria. The current proposed mechanism of action involves an acyl-intermediate, where the enzyme becomes covalently attached to the drug at ...
Powers, Rachel, Leonard, David, Anwar, Mujahid, Docter, Brianne, Wallar, Bradley   +4 more
core  

Genetic adaptation to amoxicillin in Escherichia coli: The limited role of dinB and katE.

PLoS ONE
Bacteria can quickly adapt to sub-lethal concentrations of antibiotics. Several stress and DNA repair genes contribute to this adaptation process. However, the pathways leading to adaptation by acquisition of de novo mutations remain poorly understood ...
Lisa Teichmann, Marcus Wenne, Sam Luitwieler, Gaurav Dugar, Johan Bengtsson-Palme, Benno Ter Kuile   +5 more
doaj   +1 more source

Selection of cefoxitin-resistant Bacteroides thetaiotaomicron mutants and mechanisms involved in beta-lactam resistance

, 2002
The beta-lactam antibiotics are the most widely used of all the groups of antimicrobials, but beta-lactam resistance is increasingly common among members of the Bacteroides fragilis group.
Nord, C E, Nord, CE, Edlund, Charlotta,, Hedberg, M, Fang, Hong, Edlund, C, Fang, H,   +6 more
core   +1 more source

A study of clinical strains of Pseudomonas Aeruginosa and the investigation of antibiotic resistance mechanisms in the multidrug resistant strain PA13 [PDF]

, 2008
Thirteen clinical strains of bacteria from two Irish hospitals were identified as Pseudomonas aeruginosa using classical methods, API 20NE and Biolog GN. Their identification was confirmed by 16S rRNA gene sequencing.
Ferguson, Damien
core   +2 more sources

New boronate drugs and evolving NDM-mediated beta-lactam resistance. [PDF]

Antimicrob Agents Chemother, 2023
Lomovskaya O, Tsivkovski R, Totrov M, Dressel D, Castanheira M, Dudley M.   +5 more
europepmc   +1 more source

Beta-Lactam Resistance Mechanisms in Pseudomonas aeruginosa Strains Causing Bloodstream Infections: Comparative Results Between Brazilian and American Isolates

, 2012
This study evaluated the presence of distinct mechanisms of beta-lactam resistance in 122 Pseudomonas aeruginosa isolates, causing bloodstream infections at Hospital São Paulo (HSP, Brazil; 82 isolates) and Virginia Commonwealth University Medical Center
Edmond, Michael B., Gales, Ana C., Fehlberg, Lorena C. C. [UNIFESP], Peraro, Paula P., Xavier, Danilo E., Marra, Alexandre R.   +5 more
core   +1 more source