Results 71 to 80 of about 78,679 (204)

Comparison of Effectiveness between Combination of Beta-Lactam with Azyhtromycin or Levofloxacin for Adult Pneumonia Patients

Pharmacology and Clinical Pharmacy Research, 2018
Treatment for pneumonia has always been a challenge due to the difficulties in diagnosis and the growing incidence of antibiotic resistance. Beta-lactam antibiotics are the first line treatment for pneumonia.
Gina Arifah, Eli Halimah, Rizky Abdulah
doaj   +1 more source

Extended-spectrum beta-lactamases-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru [PDF]

, 2018
Antibiotic resistance mediated by bacterial production of extended‐spectrum beta‐lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital‐acquired; however, infections acquired outside of hospital settings have ...
A. Appelgren, C. Shiva, C. Tello, D. G. Streicker, J. A. Benavides, J. Solassol, J. Vendrell, M. Virhuez, S. Godreuil, World Health Organization   +9 more
core   +3 more sources

Evidence for the evolutionary steps leading to mecA-mediated ß-lactam resistance in staphylococci [PDF]

, 2017
The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA–an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams.
Bouchami, O, Bowden, R, Boye Nielsen, J, Damborg, P, de Lencastre, H, Guardabassi, L, Hughes, D, Miragaia, M, Perreten, V, Rolo, J, Sobral, R, Tomasz, A, Westh, H, Worning, P   +13 more
core   +6 more sources

Dissemination of IncF plasmids carrying beta-lactamase genes in Gram-negative bacteria from Nigerian hospitals

Journal of Infection in Developing Countries, 2013
Introduction: Production of beta-lactamases is the predominant cause of resistance to beta-lactam antibiotics in Gram-negative bacteria. We investigated the diversity of plasmid-borne beta-lactamase genes and replicon type of the plasmids carrying the ...
David Olusoga Ogbolu, Oluwole Adebayo Daini, Afolabi Ogunledun, Oyebode Armstrong Terry Alli, Mark Alexander Webber   +4 more
doaj   +1 more source

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Gidijala, Loknath,, Kiel, Jan A.K.W.,, Klei, Ida J. van der,, Veenhuis, Marten,   +3 more
core   +2 more sources

Beta-Lactam Resistance: Clinical Implications for Pediatric Patients

Journal of International Medical Research, 2002
The emergence of resistance to established antibiotic agents such as beta-lactams has been reported worldwide and poses a serious challenge to the management of pediatric infections. The most common mechanism of resistance involves the production of an enzyme that inactivates the antibiotic before it can be effective.
openaire   +2 more sources

Potential involvement of beta-lactamase homologous proteins in resistance to beta-lactam antibiotics in gram-negative bacteria of the ESKAPEE group

BMC Genomics
Background Enzymatic degradation mediated by beta-lactamases constitutes one of the primary mechanisms of resistance to beta-lactam antibiotics in gram-negative bacteria.
Joyce de Souza, Alexandre Zanatta Vieira, Hellen Geremias dos Santos, Helisson Faoro   +3 more
doaj   +1 more source

Extended spectrum Beta-Lactamase (ESBL) producing Enterobacterales: Classification and resistance genetic background [PDF]

Medicinski Podmladak, 2019
Beta-lactam antibiotics are one of the most important ones in clinical practice and most commonly prescribed drugs. There are few possible mechanisms of beta-lactam resistance.
Milić Marija, Mijač Vera
doaj  

Genetic adaptation to amoxicillin in Escherichia coli: The limited role of dinB and katE.

PLoS ONE
Bacteria can quickly adapt to sub-lethal concentrations of antibiotics. Several stress and DNA repair genes contribute to this adaptation process. However, the pathways leading to adaptation by acquisition of de novo mutations remain poorly understood ...
Lisa Teichmann, Marcus Wenne, Sam Luitwieler, Gaurav Dugar, Johan Bengtsson-Palme, Benno Ter Kuile   +5 more
doaj   +1 more source

Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli

Molecules
Background: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat.
Youqi Ji, Yinhuan Wang, Zhangkai Xu, Danlei Chen, Zhendi Yu, Qingyi Shao, Xin Hong, Zishu Liu, Dongqing Cheng   +8 more
doaj   +1 more source